Crystal Structure of a Surrogate Light Chain (Lambda5 and Vpreb) Homodimer
| PDB | 2h3n |
| Species | HOMO SAPIENS |
| Method | X-RAY DIFFRACTION |
| Resolution | 2.3Å |
| Number of Fvs | 2 |
| In complex | True |
| Light chain type | unknown |
| Has constant region | False |
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Display options: |
This PDB has 2 Fv(s).
| Fv Details | |
|---|---|
| Heavy chain | |
| Light chain | A |
| Heavy subgroup | unknown |
| Light subgroup | unknown |
| Species | HOMO SAPIENS |
| In complex? | True |
| scFv? | False |
| Has constant domain? | False |
| Numbered Sequences (chothia) |
|---|
Light chain
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 30A | 30B | 30C | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 54A | 54B | 54C | 54D | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 66A | 66B | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Q | P | V | L | H | Q | P | P | A | M | S | S | A | L | G | T | T | I | R | L | T | C | T | L | R | N | D | H | D | I | G | V | Y | S | V | Y | W | Y | Q | Q | R | P | G | H | P | P | R | F | L | L | R | Y | F | S | Q | S | D | K | S | Q | G | P | Q | V | P | P | R | F | S | G | S | K | D | V | A | R | N | R | G | Y | L | S | I | S | E | L | Q | P | E | D | E | A | M | Y | Y | C | A | M |
| Antigen Details | |
|---|---|
| Antigen chains | B |
| Antigen type | protein |
| Antigen name | ig lambda-5 |
| Antigen species | HOMO SAPIENS |
| Antigen sequence | VTHVFGSGTQLTVLSQPKATPSVTLFPPSSEELQANKATLVCLMNDFYPGILTVTWKADGTPITQGVEMTTPSKQSNNKYAASSYLSLTPEQWRSRRSYSCQVMHEGSTVEKTVAPA |
| CDR Sequences (chothia definition) | |
|---|---|
| CDRL1 | TLRNDHDIGVYSVY |
| CDRL2 | YFSQSDKSQGP |
| CDRL3 | AM |
| Fv Details | |
|---|---|
| Heavy chain | |
| Light chain | C |
| Heavy subgroup | unknown |
| Light subgroup | unknown |
| Species | HOMO SAPIENS |
| In complex? | True |
| scFv? | False |
| Has constant domain? | False |
| Numbered Sequences (chothia) |
|---|
Light chain
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 30A | 30B | 30C | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 54A | 54B | 54C | 54D | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 66A | 66B | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Q | P | V | L | H | Q | P | P | A | M | S | S | A | L | G | T | T | I | R | L | T | C | T | L | R | N | D | H | D | I | G | V | Y | S | V | Y | W | Y | Q | Q | R | P | G | H | P | P | R | F | L | L | R | Y | F | S | Q | S | D | K | S | Q | G | P | Q | V | P | P | R | F | S | G | S | K | D | V | A | R | N | R | G | Y | L | S | I | S | E | L | Q | P | E | D | E | A | M | Y | Y | C | A | M |
| Antigen Details | |
|---|---|
| Antigen chains | D |
| Antigen type | protein |
| Antigen name | ig lambda-5 |
| Antigen species | HOMO SAPIENS |
| Antigen sequence | VTHVFGSGTQLTVLSQPKATPSVTLFPPSSEELQANKATLVCLMNDFYPGILTVTWKADGTPITQGVEMTTPSKQSNNKYAASSYLSLTPEQWRSRRSYSCQVMHEGSTVEKTVAPA |
| CDR Sequences (chothia definition) | |
|---|---|
| CDRL1 | TLRNDHDIGVYSVY |
| CDRL2 | YFSQSDKSQGP |
| CDRL3 | AM |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
