Structure Viewer: 2otw

>   Structure details

Crystal Structure of Fv Polyglutamine complex

PDB2otw
SpeciesMUS MUSCULUS
MethodX-RAY DIFFRACTION
Resolution2.35Å
Number of Fvs2
In complexTrue
Light chain typeLambda
Has constant regionFalse
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>   Fv information

This PDB has 2 Fv(s).

>   B/A
Fv Details
Heavy chainB
Light chainA
Heavy subgroupIGHV5
Light subgroupIGLV3
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L V Q P G G S L K L S C A A S G F T F R D Y Y M Y W V R Q T P E K R L E W V A F I S N G G G S T Y Y P D T V K G R F T I S R D N A K N T L Y L Q M S R L K S E D T A M Y Y C A R G R G Y V W F A Y W G Q G T T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 54A 54B 54C 54D 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 95D 96 97 98 99 100 101 102 103 104 105 106
Q L V L T Q S S S A S F S L G A S A K L T C T L S S Q H S T Y T I E W Y Q Q Q P L K P P K Y V M E L K K D G S H S T G D G I P D R F S G S S S G A D R Y L S I S N I Q P E D E A I Y I C G V G D T I K E Q F V Y V F G G G T K V T V

Antigen Details
Antigen chainsE
Antigen typepeptide
Antigen namepoly-gln peptide antigen
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequenceGQQQQQQQQQQG

CDR Sequences (chothia definition)
CDRH1GFTFRDY
CDRH2SNGGGS
CDRH3GRGYVWFAY
CDRL1TLSSQHSTYTIE
CDRL2LKKDGSHSTGD
CDRL3GVGDTIKEQFVYV

Orientation Angles (from ABangle)
HL-61.79°
HC174.61°
HC2118.52°
LC1119.57°
LC286.32°
dc15.96Å
>   D/C
Fv Details
Heavy chainD
Light chainC
Heavy subgroupIGHV5
Light subgroupIGLV3
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L V Q P G G S L K L S C A A S G F T F R D Y Y M Y W V R Q T P E K R L E W V A F I S N G G G S T Y Y P D T V K G R F T I S R D N A K N T L Y L Q M S R L K S E D T A M Y Y C A R G R G Y V W F A Y W G Q G T T V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 54A 54B 54C 54D 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 95D 96 97 98 99 100 101 102 103 104 105 106
Q L V L T Q S S S A S F S L G A S A K L T C T L S S Q H S T Y T I E W Y Q Q Q P L K P P K Y V M E L K K D G S H S T G D G I P D R F S G S S S G A D R Y L S I S N I Q P E D E A I Y I C G V G D T I K E Q F V Y V F G G G T K V T V

Antigen Details
Antigen chainsF
Antigen typepeptide
Antigen namepoly-gln peptide antigen
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequenceGQQQQQQQQQQG

CDR Sequences (chothia definition)
CDRH1GFTFRDY
CDRH2SNGGGS
CDRH3GRGYVWFAY
CDRL1TLSSQHSTYTIE
CDRL2LKKDGSHSTGD
CDRL3GVGDTIKEQFVYV

Orientation Angles (from ABangle)
HL-61.32°
HC175.22°
HC2118.5°
LC1121.79°
LC284.98°
dc15.84Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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