Structure Viewer: 2rcj

> Structure details

Solution Structure of Human Immunoglobulin M

PDB	2rcj
Species	HOMO SAPIENS
Method	SOLUTION SCATTERING
Resolution	NA
Number of Fvs	10
In complex	True
Light chain type	Lambda
Has constant region	True

> Fv information

This PDB has 10 Fv(s).

Fv Details
Heavy chain	R
Light chain	S
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	G	G	V	V	Q	P	G	R	S	L	R	L	S	C	S	S	S	G	F	I	F	S	S	Y	A	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	I	I	W	D	D	G	S	D	Q	H	Y	A	D	S	V	K	G	R	F	T	I	S	R	N	D	S	K	N	T	L	F	L	Q	M	D	S	L	R	P	E	D	T	G	V	Y	F	C	A	R	D	G	G	S	S	A	P	D	Y	W	G	Q	G	T	P	V	T	V	S	S

Light chain

2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	T	G	T	S	S	G	S	I	T	V	N	W	Y	Q	Q	L	P	G	M	A	P	K	L	L	I	Y	R	D	A	M	R	P	S	G	V	P	T	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	E	A	E	D	E	S	D	Y	Y	C	A	S	W	N	S	S	D	N	S	Y	V	F	G	T	G	T	K	V	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GFIFSSY
CDRH2	WDDGSD
CDRH3	DGGSSAPDY
CDRL1	TGTSSGSITVN
CDRL2	RDAMRPS
CDRL3	ASWNSSDNSYV

Orientation Angles (from ABangle)
HL	-55.45°
HC1	71.16°
HC2	119.77°
LC1	118.05°
LC2	81.77°
dc	16.01Å

Fv Details
Heavy chain	A
Light chain	D
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	G	G	V	V	Q	P	G	R	S	L	R	L	S	C	S	S	S	G	F	I	F	S	S	Y	A	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	I	I	W	D	D	G	S	D	Q	H	Y	A	D	S	V	K	G	R	F	T	I	S	R	N	D	S	K	N	T	L	F	L	Q	M	D	S	L	R	P	E	D	T	G	V	Y	F	C	A	R	D	G	G	S	S	A	P	D	Y	W	G	Q	G	T	P	V	T	V	S	S

Light chain

2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	T	G	T	S	S	G	S	I	T	V	N	W	Y	Q	Q	L	P	G	M	A	P	K	L	L	I	Y	R	D	A	M	R	P	S	G	V	P	T	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	E	A	E	D	E	S	D	Y	Y	C	A	S	W	N	S	S	D	N	S	Y	V	F	G	T	G	T	K	V	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GFIFSSY
CDRH2	WDDGSD
CDRH3	DGGSSAPDY
CDRL1	TGTSSGSITVN
CDRL2	RDAMRPS
CDRL3	ASWNSSDNSYV

Orientation Angles (from ABangle)
HL	-55.45°
HC1	71.16°
HC2	119.77°
LC1	118.05°
LC2	81.77°
dc	16.01Å

Fv Details
Heavy chain	B
Light chain	C
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	G	G	V	V	Q	P	G	R	S	L	R	L	S	C	S	S	S	G	F	I	F	S	S	Y	A	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	I	I	W	D	D	G	S	D	Q	H	Y	A	D	S	V	K	G	R	F	T	I	S	R	N	D	S	K	N	T	L	F	L	Q	M	D	S	L	R	P	E	D	T	G	V	Y	F	C	A	R	D	G	G	S	S	A	P	D	Y	W	G	Q	G	T	P	V	T	V	S	S

Light chain

2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	T	G	T	S	S	G	S	I	T	V	N	W	Y	Q	Q	L	P	G	M	A	P	K	L	L	I	Y	R	D	A	M	R	P	S	G	V	P	T	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	E	A	E	D	E	S	D	Y	Y	C	A	S	W	N	S	S	D	N	S	Y	V	F	G	T	G	T	K	V	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GFIFSSY
CDRH2	WDDGSD
CDRH3	DGGSSAPDY
CDRL1	TGTSSGSITVN
CDRL2	RDAMRPS
CDRL3	ASWNSSDNSYV

Orientation Angles (from ABangle)
HL	-55.45°
HC1	71.16°
HC2	119.77°
LC1	118.05°
LC2	81.77°
dc	16.0Å

Fv Details
Heavy chain	Q
Light chain	T
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	G	G	V	V	Q	P	G	R	S	L	R	L	S	C	S	S	S	G	F	I	F	S	S	Y	A	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	I	I	W	D	D	G	S	D	Q	H	Y	A	D	S	V	K	G	R	F	T	I	S	R	N	D	S	K	N	T	L	F	L	Q	M	D	S	L	R	P	E	D	T	G	V	Y	F	C	A	R	D	G	G	S	S	A	P	D	Y	W	G	Q	G	T	P	V	T	V	S	S

Light chain

2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	T	G	T	S	S	G	S	I	T	V	N	W	Y	Q	Q	L	P	G	M	A	P	K	L	L	I	Y	R	D	A	M	R	P	S	G	V	P	T	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	E	A	E	D	E	S	D	Y	Y	C	A	S	W	N	S	S	D	N	S	Y	V	F	G	T	G	T	K	V	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GFIFSSY
CDRH2	WDDGSD
CDRH3	DGGSSAPDY
CDRL1	TGTSSGSITVN
CDRL2	RDAMRPS
CDRL3	ASWNSSDNSYV

Orientation Angles (from ABangle)
HL	-55.45°
HC1	71.16°
HC2	119.77°
LC1	118.05°
LC2	81.77°
dc	16.01Å

Fv Details
Heavy chain	N
Light chain	O
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	G	G	V	V	Q	P	G	R	S	L	R	L	S	C	S	S	S	G	F	I	F	S	S	Y	A	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	I	I	W	D	D	G	S	D	Q	H	Y	A	D	S	V	K	G	R	F	T	I	S	R	N	D	S	K	N	T	L	F	L	Q	M	D	S	L	R	P	E	D	T	G	V	Y	F	C	A	R	D	G	G	S	S	A	P	D	Y	W	G	Q	G	T	P	V	T	V	S	S

Light chain

2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	T	G	T	S	S	G	S	I	T	V	N	W	Y	Q	Q	L	P	G	M	A	P	K	L	L	I	Y	R	D	A	M	R	P	S	G	V	P	T	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	E	A	E	D	E	S	D	Y	Y	C	A	S	W	N	S	S	D	N	S	Y	V	F	G	T	G	T	K	V	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GFIFSSY
CDRH2	WDDGSD
CDRH3	DGGSSAPDY
CDRL1	TGTSSGSITVN
CDRL2	RDAMRPS
CDRL3	ASWNSSDNSYV

Orientation Angles (from ABangle)
HL	-55.45°
HC1	71.16°
HC2	119.77°
LC1	118.05°
LC2	81.77°
dc	16.01Å

Fv Details
Heavy chain	E
Light chain	H
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	G	G	V	V	Q	P	G	R	S	L	R	L	S	C	S	S	S	G	F	I	F	S	S	Y	A	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	I	I	W	D	D	G	S	D	Q	H	Y	A	D	S	V	K	G	R	F	T	I	S	R	N	D	S	K	N	T	L	F	L	Q	M	D	S	L	R	P	E	D	T	G	V	Y	F	C	A	R	D	G	G	S	S	A	P	D	Y	W	G	Q	G	T	P	V	T	V	S	S

Light chain

2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	T	G	T	S	S	G	S	I	T	V	N	W	Y	Q	Q	L	P	G	M	A	P	K	L	L	I	Y	R	D	A	M	R	P	S	G	V	P	T	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	E	A	E	D	E	S	D	Y	Y	C	A	S	W	N	S	S	D	N	S	Y	V	F	G	T	G	T	K	V	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GFIFSSY
CDRH2	WDDGSD
CDRH3	DGGSSAPDY
CDRL1	TGTSSGSITVN
CDRL2	RDAMRPS
CDRL3	ASWNSSDNSYV

Orientation Angles (from ABangle)
HL	-55.45°
HC1	71.16°
HC2	119.77°
LC1	118.05°
LC2	81.77°
dc	16.01Å

Fv Details
Heavy chain	M
Light chain	P
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	G	G	V	V	Q	P	G	R	S	L	R	L	S	C	S	S	S	G	F	I	F	S	S	Y	A	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	I	I	W	D	D	G	S	D	Q	H	Y	A	D	S	V	K	G	R	F	T	I	S	R	N	D	S	K	N	T	L	F	L	Q	M	D	S	L	R	P	E	D	T	G	V	Y	F	C	A	R	D	G	G	S	S	A	P	D	Y	W	G	Q	G	T	P	V	T	V	S	S

Light chain

2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	T	G	T	S	S	G	S	I	T	V	N	W	Y	Q	Q	L	P	G	M	A	P	K	L	L	I	Y	R	D	A	M	R	P	S	G	V	P	T	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	E	A	E	D	E	S	D	Y	Y	C	A	S	W	N	S	S	D	N	S	Y	V	F	G	T	G	T	K	V	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GFIFSSY
CDRH2	WDDGSD
CDRH3	DGGSSAPDY
CDRL1	TGTSSGSITVN
CDRL2	RDAMRPS
CDRL3	ASWNSSDNSYV

Orientation Angles (from ABangle)
HL	-55.45°
HC1	71.16°
HC2	119.77°
LC1	118.05°
LC2	81.77°
dc	16.01Å

Fv Details
Heavy chain	J
Light chain	K
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	G	G	V	V	Q	P	G	R	S	L	R	L	S	C	S	S	S	G	F	I	F	S	S	Y	A	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	I	I	W	D	D	G	S	D	Q	H	Y	A	D	S	V	K	G	R	F	T	I	S	R	N	D	S	K	N	T	L	F	L	Q	M	D	S	L	R	P	E	D	T	G	V	Y	F	C	A	R	D	G	G	S	S	A	P	D	Y	W	G	Q	G	T	P	V	T	V	S	S

Light chain

2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	T	G	T	S	S	G	S	I	T	V	N	W	Y	Q	Q	L	P	G	M	A	P	K	L	L	I	Y	R	D	A	M	R	P	S	G	V	P	T	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	E	A	E	D	E	S	D	Y	Y	C	A	S	W	N	S	S	D	N	S	Y	V	F	G	T	G	T	K	V	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GFIFSSY
CDRH2	WDDGSD
CDRH3	DGGSSAPDY
CDRL1	TGTSSGSITVN
CDRL2	RDAMRPS
CDRL3	ASWNSSDNSYV

Orientation Angles (from ABangle)
HL	-55.45°
HC1	71.16°
HC2	119.77°
LC1	118.05°
LC2	81.77°
dc	16.01Å

Fv Details
Heavy chain	I
Light chain	L
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	G	G	V	V	Q	P	G	R	S	L	R	L	S	C	S	S	S	G	F	I	F	S	S	Y	A	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	I	I	W	D	D	G	S	D	Q	H	Y	A	D	S	V	K	G	R	F	T	I	S	R	N	D	S	K	N	T	L	F	L	Q	M	D	S	L	R	P	E	D	T	G	V	Y	F	C	A	R	D	G	G	S	S	A	P	D	Y	W	G	Q	G	T	P	V	T	V	S	S

Light chain

2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	T	G	T	S	S	G	S	I	T	V	N	W	Y	Q	Q	L	P	G	M	A	P	K	L	L	I	Y	R	D	A	M	R	P	S	G	V	P	T	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	E	A	E	D	E	S	D	Y	Y	C	A	S	W	N	S	S	D	N	S	Y	V	F	G	T	G	T	K	V	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GFIFSSY
CDRH2	WDDGSD
CDRH3	DGGSSAPDY
CDRL1	TGTSSGSITVN
CDRL2	RDAMRPS
CDRL3	ASWNSSDNSYV

Orientation Angles (from ABangle)
HL	-55.45°
HC1	71.16°
HC2	119.77°
LC1	118.05°
LC2	81.77°
dc	16.01Å

Fv Details
Heavy chain	F
Light chain	G
Heavy subgroup	IGHV3
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	Q	S	G	G	G	V	V	Q	P	G	R	S	L	R	L	S	C	S	S	S	G	F	I	F	S	S	Y	A	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	I	I	W	D	D	G	S	D	Q	H	Y	A	D	S	V	K	G	R	F	T	I	S	R	N	D	S	K	N	T	L	F	L	Q	M	D	S	L	R	P	E	D	T	G	V	Y	F	C	A	R	D	G	G	S	S	A	P	D	Y	W	G	Q	G	T	P	V	T	V	S	S

Light chain

2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	T	G	T	S	S	G	S	I	T	V	N	W	Y	Q	Q	L	P	G	M	A	P	K	L	L	I	Y	R	D	A	M	R	P	S	G	V	P	T	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	E	A	E	D	E	S	D	Y	Y	C	A	S	W	N	S	S	D	N	S	Y	V	F	G	T	G	T	K	V	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GFIFSSY
CDRH2	WDDGSD
CDRH3	DGGSSAPDY
CDRL1	TGTSSGSITVN
CDRL2	RDAMRPS
CDRL3	ASWNSSDNSYV

Orientation Angles (from ABangle)
HL	-55.45°
HC1	71.16°
HC2	119.77°
LC1	118.05°
LC2	81.77°
dc	16.0Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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