integrin alphaiibbeta3 Headpiece Bound to Fibrinogen Gamma Chain Peptide, Hhlggakqagdv
| PDB | 2vdo |
| Species | MUS MUSCULUS |
| Method | X-RAY DIFFRACTION |
| Resolution | 2.51Å |
| Number of Fvs | 1 |
| In complex | True |
| Light chain type | Kappa |
| Has constant region | True |
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Display options: |
This PDB has 1 Fv(s).
| Fv Details | |
|---|---|
| Heavy chain | H |
| Light chain | L |
| Heavy subgroup | IGHV14 |
| Light subgroup | IGKV14 |
| Species | MUS MUSCULUS |
| In complex? | True |
| scFv? | False |
| Has constant domain? | True |
| Numbered Sequences (chothia) |
|---|
Heavy chain
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Light chain
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| D | I | L | M | T | Q | S | P | S | S | M | S | V | S | L | G | D | T | V | S | I | T | C | H | A | S | Q | G | I | S | S | N | I | G | W | L | Q | Q | K | P | G | K | S | F | M | G | L | I | Y | Y | G | T | N | L | V | D | G | V | P | S | R | F | S | G | S | G | S | G | A | D | Y | S | L | T | I | S | S | L | D | S | E | D | F | A | D | Y | Y | C | V | Q | Y | A | Q | L | P | Y | T | F | G | G | G | T | K | L | E | I | K |
| Antigen Details | |
|---|---|
| Antigen chains | A |
| Antigen type | protein |
| Antigen name | integrin alpha-iib |
| Antigen species | HOMO SAPIENS |
| Antigen sequence | LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQP |
| CDR Sequences (chothia definition) | |
|---|---|
| CDRH1 | GFNIKDT |
| CDRH2 | DPANGY |
| CDRH3 | PLYDYYAMDY |
| CDRL1 | HASQGISSNIG |
| CDRL2 | YGTNLVD |
| CDRL3 | VQYAQLPYT |
| Orientation Angles (from ABangle) | |
|---|---|
| HL | -60.99° |
| HC1 | 69.15° |
| HC2 | 111.68° |
| LC1 | 119.84° |
| LC2 | 81.39° |
| dc | 15.77Å |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
