Structure Viewer: 3pnw

> Structure details

Crystal Structure of the Tudor Domain of Human Tdrd3 in complex with an anti-Tdrd3 Fab

PDB	3pnw
Species	SYNTHETIC CONSTRUCT
Method	X-RAY DIFFRACTION
Resolution	2.05Å
Number of Fvs	8
In complex	True
Light chain type	Kappa
Has constant region	True

> Fv information

This PDB has 8 Fv(s).

Fv Details
Heavy chain	B
Light chain	A
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	L	S	S	S	Y	M	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	Y	G	S	T	Y	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	V	R	G	S	K	K	P	Y	F	S	G	W	A	M	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	H	G	P	F	Y	W	L	F	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	tudor domain-containing protein 3
Antigen species	HOMO SAPIENS
Antigen sequence	GPEKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEVLLSNIKPIQTEAWEE

CDR Sequences (chothia definition)
CDRH1	GFNLSSS
CDRH2	SSSYGS
CDRH3	TVRGSKKPYFSGWAMDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQHGPFYWLFT

Orientation Angles (from ABangle)
HL	-61.58°
HC1	69.88°
HC2	119.04°
LC1	119.23°
LC2	81.97°
dc	16.03Å

Fv Details
Heavy chain	W
Light chain	V
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	L	S	S	S	Y	M	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	Y	G	S	T	Y	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	V	R	G	S	K	K	P	Y	F	S	G	W	A	M	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	H	G	P	F	Y	W	L	F	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	X
Antigen type	protein
Antigen name	tudor domain-containing protein 3
Antigen species	HOMO SAPIENS
Antigen sequence	GPEKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEVLLSNIKPIQTEAWEE

CDR Sequences (chothia definition)
CDRH1	GFNLSSS
CDRH2	SSSYGS
CDRH3	TVRGSKKPYFSGWAMDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQHGPFYWLFT

Orientation Angles (from ABangle)
HL	-59.55°
HC1	70.02°
HC2	119.13°
LC1	119.45°
LC2	82.08°
dc	16.1Å

Fv Details
Heavy chain	K
Light chain	J
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	L	S	S	S	Y	M	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	Y	G	S	T	Y	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	V	R	G	S	K	K	P	Y	F	S	G	W	A	M	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	H	G	P	F	Y	W	L	F	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	L
Antigen type	protein
Antigen name	tudor domain-containing protein 3
Antigen species	HOMO SAPIENS
Antigen sequence	GPEKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEVLLSNIKPIQTEAWEE

CDR Sequences (chothia definition)
CDRH1	GFNLSSS
CDRH2	SSSYGS
CDRH3	TVRGSKKPYFSGWAMDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQHGPFYWLFT

Orientation Angles (from ABangle)
HL	-60.18°
HC1	69.81°
HC2	119.43°
LC1	119.56°
LC2	82.07°
dc	16.08Å

Fv Details
Heavy chain	Q
Light chain	P
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	L	S	S	S	Y	M	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	Y	G	S	T	Y	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	V	R	G	S	K	K	P	Y	F	S	G	W	A	M	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	H	G	P	F	Y	W	L	F	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	R
Antigen type	protein
Antigen name	tudor domain-containing protein 3
Antigen species	HOMO SAPIENS
Antigen sequence	GPEKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEVLLSNIKPIQTEAWEE

CDR Sequences (chothia definition)
CDRH1	GFNLSSS
CDRH2	SSSYGS
CDRH3	TVRGSKKPYFSGWAMDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQHGPFYWLFT

Orientation Angles (from ABangle)
HL	-60.71°
HC1	69.74°
HC2	119.21°
LC1	118.22°
LC2	82.63°
dc	16.14Å

Fv Details
Heavy chain	N
Light chain	M
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	L	S	S	S	Y	M	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	Y	G	S	T	Y	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	V	R	G	S	K	K	P	Y	F	S	G	W	A	M	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	H	G	P	F	Y	W	L	F	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	O
Antigen type	protein
Antigen name	tudor domain-containing protein 3
Antigen species	HOMO SAPIENS
Antigen sequence	GPEKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEVLLSNIKPIQTEAWEE

CDR Sequences (chothia definition)
CDRH1	GFNLSSS
CDRH2	SSSYGS
CDRH3	TVRGSKKPYFSGWAMDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQHGPFYWLFT

Orientation Angles (from ABangle)
HL	-61.58°
HC1	69.64°
HC2	119.13°
LC1	119.48°
LC2	81.96°
dc	16.09Å

Fv Details
Heavy chain	E
Light chain	D
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	L	S	S	S	Y	M	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	Y	G	S	T	Y	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	V	R	G	S	K	K	P	Y	F	S	G	W	A	M	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	H	G	P	F	Y	W	L	F	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	F
Antigen type	protein
Antigen name	tudor domain-containing protein 3
Antigen species	HOMO SAPIENS
Antigen sequence	GPEKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEVLLSNIKPIQTEAWEE

CDR Sequences (chothia definition)
CDRH1	GFNLSSS
CDRH2	SSSYGS
CDRH3	TVRGSKKPYFSGWAMDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQHGPFYWLFT

Orientation Angles (from ABangle)
HL	-61.17°
HC1	69.88°
HC2	119.74°
LC1	119.28°
LC2	82.66°
dc	16.08Å

Fv Details
Heavy chain	H
Light chain	G
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	L	S	S	S	Y	M	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	Y	G	S	T	Y	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	V	R	G	S	K	K	P	Y	F	S	G	W	A	M	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	H	G	P	F	Y	W	L	F	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	I
Antigen type	protein
Antigen name	tudor domain-containing protein 3
Antigen species	HOMO SAPIENS
Antigen sequence	GPEKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEVLLSNIKPIQTEAWEE

CDR Sequences (chothia definition)
CDRH1	GFNLSSS
CDRH2	SSSYGS
CDRH3	TVRGSKKPYFSGWAMDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQHGPFYWLFT

Orientation Angles (from ABangle)
HL	-60.42°
HC1	69.98°
HC2	119.32°
LC1	118.47°
LC2	82.88°
dc	16.08Å

Fv Details
Heavy chain	T
Light chain	S
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	N	L	S	S	S	Y	M	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	A	S	I	S	S	S	Y	G	S	T	Y	Y	A	D	S	V	K	G	R	F	T	I	S	A	D	T	S	K	N	T	A	Y	L	Q	M	N	S	L	R	A	E	D	T	A	V	Y	Y	C	A	R	T	V	R	G	S	K	K	P	Y	F	S	G	W	A	M	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	V	S	S	A	V	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	S	A	S	S	L	Y	S	G	V	P	S	R	F	S	G	S	R	S	G	T	D	F	T	L	T	I	S	S	L	Q	P	E	D	F	A	T	Y	Y	C	Q	Q	H	G	P	F	Y	W	L	F	T	F	G	Q	G	T	K	V	E	I	K

Antigen Details
Antigen chains	U
Antigen type	protein
Antigen name	tudor domain-containing protein 3
Antigen species	HOMO SAPIENS
Antigen sequence	GPEKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEVLLSNIKPIQTEAWEE

CDR Sequences (chothia definition)
CDRH1	GFNLSSS
CDRH2	SSSYGS
CDRH3	TVRGSKKPYFSGWAMDY
CDRL1	RASQSVSSAVA
CDRL2	SASSLYS
CDRL3	QQHGPFYWLFT

Orientation Angles (from ABangle)
HL	-60.97°
HC1	69.94°
HC2	119.39°
LC1	119.68°
LC2	82.03°
dc	15.99Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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