Structure Viewer: 5c0n

>   Structure details

Development of a Monoclonal antibody Targeting Secreted ap2 to Treat Diabetes and Fatty Liver Disease

PDB5c0n
SpeciesORYCTOLAGUS CUNICULUS
MethodX-RAY DIFFRACTION
Resolution3.0Å
Number of Fvs2
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   C/D
Fv Details
Heavy chainC
Light chainD
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesORYCTOLAGUS CUNICULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q S V E E S G G R L V T P G T P L T L T C T V S G F S L S T Y Y M S W V R Q A P G K G L E W I G I I Y P S G S T Y C A S W A K G R F T I S K A S T T V D L K I T S P T T E D T A T Y F C A R P D N D G T S G Y L S G F G L W G Q G T L V T V S S

Light chain

2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 95D 95E 96 97 98 99 100 101 102 103 104 105 106 107
V V M T Q T P A S V S E P V G G T V T I K C Q A S E D I S R Y L V W Y Q Q K P G Q P P K R L I Y K A S T L A S G V P S R F K G S G S G T D F T L T I S D L E C D D A A T Y Y C Q C T Y G T Y A G S F F Y S F G G G T E V V V E

Antigen Details
Antigen chainsB
Antigen typeprotein
Antigen namefatty acid-binding protein, adipocyte
Antigen speciesMUS MUSCULUS
Antigen sequenceMCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKVKSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYERA

CDR Sequences (chothia definition)
CDRH1GFSLSTY
CDRH2YPSGS
CDRH3PDNDGTSGYLSGFGL
CDRL1QASEDISRYLV
CDRL2KASTLAS
CDRL3QCTYGTYAGSFFYS

Orientation Angles (from ABangle)
HL-56.48°
HC171.3°
HC2120.76°
LC1120.15°
LC280.52°
dc16.49Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesORYCTOLAGUS CUNICULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q S V E E S G G R L V T P G T P L T L T C T V S G F S L S T Y Y M S W V R Q A P G K G L E W I G I I Y P S G S T Y C A S W A K G R F T I S K A S T T V D L K I T S P T T E D T A T Y F C A R P D N D G T S G Y L S G F G L W G Q G T L V T V S S

Light chain

2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 95D 95E 96 97 98 99 100 101 102 103 104 105 106 107
V V M T Q T P A S V S E P V G G T V T I K C Q A S E D I S R Y L V W Y Q Q K P G Q P P K R L I Y K A S T L A S G V P S R F K G S G S G T D F T L T I S D L E C D D A A T Y Y C Q C T Y G T Y A G S F F Y S F G G G T E V V V E

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namefatty acid-binding protein, adipocyte
Antigen speciesMUS MUSCULUS
Antigen sequenceMCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKVKSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYERA

CDR Sequences (chothia definition)
CDRH1GFSLSTY
CDRH2YPSGS
CDRH3PDNDGTSGYLSGFGL
CDRL1QASEDISRYLV
CDRL2KASTLAS
CDRL3QCTYGTYAGSFFYS

Orientation Angles (from ABangle)
HL-57.0°
HC171.04°
HC2120.35°
LC1120.05°
LC280.32°
dc16.54Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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