Structure Viewer: 5whz

> Structure details

Pgdm1400-10E8V4 Codv Fab

PDB	5whz
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	3.549Å
Number of Fvs	2
In complex	True
Light chain type	,Lambda
Has constant region	False

> Fv information

This PDB has 2 Fv(s).

Fv Details
Heavy chain	H
Light chain
Heavy subgroup	IGHV3
Light subgroup
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	102
Q	V	H	L	T	Q	S	G	P	E	V	R	K	P	G	T	S	V	K	V	S	C	K	A	P	G	N	T	L	K	T	Y	D	L	H	W	V	R	S	V	P	G	Q	G	L	Q	W	M	G	W	I	S	H	E	G	D	K	K	V	I	V	E	R	F	K	A	K	V	T	I	D	W	D	R	S	T	N	T	A	Y	L	Q	L	S	G	L	T	S	G	D	T	A	V	Y	Y	C	A	K	G

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GNTLKTY
CDRH2	SHEGDK
CDRH3	G

Fv Details
Heavy chain
Light chain	L
Heavy subgroup
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
S	E	L	T	Q	D	P	A	V	S	V	A	L	K	Q	T	V	T	I	T	C	R	G	D	S	L	R	S	H	Y	A	S	W	Y	Q	K	K	P	G	Q	A	P	V	L	L	F	Y	G	K	N	N	R	P	S	G	I	P	D	R	F	S	G	S	A	S	G	N	R	A	S	L	T	I	T	G	A	Q	A	E	D	E	A	D	Y	Y	C	S	S	R	D	K	S	G	S	R	L	S	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRL1	RGDSLRSHYAS
CDRL2	GKNNRPS
CDRL3	SSRDKSGSRLSV

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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