Structure Viewer: 6ba5

>   Structure details

Potent and Selective antitumor activity of a T-Cell Engaging Bispecific antibody Targeting a Membrane-Proximal Epitope of Ror1

PDB6ba5
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution1.62Å
Number of Fvs4
In complexTrue
Light chain typeKappa
Has constant regionFalse
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>   Fv information

This PDB has 4 Fv(s).

>   F/E
Fv Details
Heavy chainF
Light chainE
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
Q S V K E S E G D L V T P A G N L T L T C T A S G S D I N D Y P I S W V R Q A P G K G L E W I G F I N S G G S T W Y A S W V K G R F T I S R T S T T V D L K M T S L T T D D T A T Y F C A R G Y S T Y Y G D F N I W G P G T L V T I S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
E L V M T Q T P S S T S G A V G G T V T I N C Q A S Q S I D S N L A W F Q Q K P G Q P P T L L I Y R A S N L A S G V P S R F S G S R S G T E Y T L T I S G V Q R E D A A T Y Y C L G G V G N V S Y R T S F G G G T E V V V K

Antigen Details
Antigen chainsO
Antigen typeprotein
Antigen nameinactive tyrosine-protein kinase transmembrane receptorror1
Antigen speciesHOMO SAPIENS
Antigen sequenceMHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPAC

CDR Sequences (chothia definition)
CDRH1GSDINDY
CDRH2NSGGS
CDRH3GYSTYYGDFNI
CDRL1QASQSIDSNLA
CDRL2RASNLAS
CDRL3LGGVGNVSYRTS

Orientation Angles (from ABangle)
HL-60.9°
HC170.64°
HC2120.21°
LC1118.74°
LC280.45°
dc15.87Å
>   D/C
Fv Details
Heavy chainD
Light chainC
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
Q S V K E S E G D L V T P A G N L T L T C T A S G S D I N D Y P I S W V R Q A P G K G L E W I G F I N S G G S T W Y A S W V K G R F T I S R T S T T V D L K M T S L T T D D T A T Y F C A R G Y S T Y Y G D F N I W G P G T L V T I S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
E L V M T Q T P S S T S G A V G G T V T I N C Q A S Q S I D S N L A W F Q Q K P G Q P P T L L I Y R A S N L A S G V P S R F S G S R S G T E Y T L T I S G V Q R E D A A T Y Y C L G G V G N V S Y R T S F G G G T E V V V K

Antigen Details
Antigen chainsN
Antigen typeprotein
Antigen nameinactive tyrosine-protein kinase transmembrane receptorror1
Antigen speciesHOMO SAPIENS
Antigen sequenceMHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPAC

CDR Sequences (chothia definition)
CDRH1GSDINDY
CDRH2NSGGS
CDRH3GYSTYYGDFNI
CDRL1QASQSIDSNLA
CDRL2RASNLAS
CDRL3LGGVGNVSYRTS

Orientation Angles (from ABangle)
HL-59.76°
HC170.08°
HC2119.71°
LC1119.34°
LC281.23°
dc15.97Å
>   H/G
Fv Details
Heavy chainH
Light chainG
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
Q S V K E S E G D L V T P A G N L T L T C T A S G S D I N D Y P I S W V R Q A P G K G L E W I G F I N S G G S T W Y A S W V K G R F T I S R T S T T V D L K M T S L T T D D T A T Y F C A R G Y S T Y Y G D F N I W G P G T L V T I S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
E L V M T Q T P S S T S G A V G G T V T I N C Q A S Q S I D S N L A W F Q Q K P G Q P P T L L I Y R A S N L A S G V P S R F S G S R S G T E Y T L T I S G V Q R E D A A T Y Y C L G G V G N V S Y R T S F G G G T E V V V K

Antigen Details
Antigen chainsP
Antigen typeprotein
Antigen nameinactive tyrosine-protein kinase transmembrane receptorror1
Antigen speciesHOMO SAPIENS
Antigen sequenceMHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPAC

CDR Sequences (chothia definition)
CDRH1GSDINDY
CDRH2NSGGS
CDRH3GYSTYYGDFNI
CDRL1QASQSIDSNLA
CDRL2RASNLAS
CDRL3LGGVGNVSYRTS

Orientation Angles (from ABangle)
HL-59.94°
HC170.55°
HC2119.87°
LC1119.31°
LC281.3°
dc15.88Å
>   B/A
Fv Details
Heavy chainB
Light chainA
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
Q S V K E S E G D L V T P A G N L T L T C T A S G S D I N D Y P I S W V R Q A P G K G L E W I G F I N S G G S T W Y A S W V K G R F T I S R T S T T V D L K M T S L T T D D T A T Y F C A R G Y S T Y Y G D F N I W G P G T L V T I S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
E L V M T Q T P S S T S G A V G G T V T I N C Q A S Q S I D S N L A W F Q Q K P G Q P P T L L I Y R A S N L A S G V P S R F S G S R S G T E Y T L T I S G V Q R E D A A T Y Y C L G G V G N V S Y R T S F G G G T E V V V K

Antigen Details
Antigen chainsM
Antigen typeprotein
Antigen nameinactive tyrosine-protein kinase transmembrane receptorror1
Antigen speciesHOMO SAPIENS
Antigen sequenceMHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPAC

CDR Sequences (chothia definition)
CDRH1GSDINDY
CDRH2NSGGS
CDRH3GYSTYYGDFNI
CDRL1QASQSIDSNLA
CDRL2RASNLAS
CDRL3LGGVGNVSYRTS

Orientation Angles (from ABangle)
HL-61.24°
HC170.88°
HC2120.48°
LC1118.68°
LC280.11°
dc15.85Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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