Structure of Hepatitis C Virus Envelope Glycoprotein E2 Core From Genotype 6a Bound to Broadly Neutralizing antibody ar3D
PDB | 6bkd |
Species | HOMO SAPIENS |
Method | X-RAY DIFFRACTION |
Resolution | 3.25Å |
Number of Fvs | 1 |
In complex | True |
Light chain type | Kappa |
Has constant region | True |
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Display options: |
This PDB has 1 Fv(s).
Fv Details | |
---|---|
Heavy chain | H |
Light chain | L |
Heavy subgroup | IGHV1 |
Light subgroup | IGKV3 |
Species | HOMO SAPIENS |
In complex? | True |
scFv? | False |
Has constant domain? | True |
Numbered Sequences (chothia) |
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Heavy chain
3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 52A | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 82A | 82B | 82C | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 97 | 98 | 99 | 100 | 100A | 100B | 100C | 100D | 100E | 100F | 100G | 100H | 100I | 100J | 100K | 100L | 100M | 100N | 101 | 102 | 103 | 104 | 105 | 106 | 107 | 108 | 109 | 110 | 111 | 112 | 113 |
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L | L | E | Q | S | G | A | E | V | K | K | P | G | S | S | V | K | V | S | C | K | A | S | G | D | T | F | R | S | Y | V | I | T | W | A | R | Q | A | P | G | Q | G | L | E | W | M | G | A | I | I | P | F | F | G | T | T | N | L | A | Q | K | F | Q | G | R | V | T | I | T | A | D | E | S | T | K | T | V | Y | M | D | L | S | S | L | R | S | D | D | T | A | V | Y | Y | C | A | K | A | G | D | L | S | V | G | G | V | L | A | G | G | V | P | H | L | R | H | F | D | P | W | G | Q | G | T | L | V | T | V | S | S |
Light chain
3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 30A | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 66 | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | 83 | 84 | 85 | 86 | 87 | 88 | 89 | 90 | 91 | 92 | 93 | 94 | 96 | 97 | 98 | 99 | 100 | 101 | 102 | 103 | 104 | 105 | 106 | 107 |
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E | L | T | Q | S | P | G | T | L | S | L | S | P | G | E | R | A | T | L | S | C | R | A | G | Q | T | V | A | S | N | S | L | A | W | Y | Q | H | K | P | G | Q | A | P | R | L | L | I | Y | G | A | S | I | R | A | S | G | I | P | D | R | F | S | G | S | G | S | G | T | D | F | T | L | T | I | S | R | L | E | P | E | D | F | A | V | Y | Y | C | Q | Q | Y | G | L | S | S | T | F | G | Q | G | T | R | L | E | I | K |
Antigen Details | |
---|---|
Antigen chains | E |
Antigen type | protein |
Antigen name | polyprotein |
Antigen species | RECOMBINANT HEPATITIS C VIRUS HK6A/JFH-1 |
Antigen sequence | QLINTNGSWHINRTALNCNDSLQTGFITSLFYAKNVDSSGCPERMAACGSSGCWHYAPRPCDVVSARTVCGPVYCFTPSPVVVGTTDKLGIPTYNWGENETDVFMLESLRPPTGGWFGCTWMNSTGFTKTCGAPPGGPTDGGSGPWITPRCLVDYPYRLWHYPCTVNFTLHKVRMFVGGIEHRFDAACN |
CDR Sequences (chothia definition) | |
---|---|
CDRH1 | GDTFRSY |
CDRH2 | IPFFGT |
CDRH3 | AGDLSVGGVLAGGVPHLRHFDP |
CDRL1 | RAGQTVASNSLA |
CDRL2 | GASIRAS |
CDRL3 | QQYGLSST |
Orientation Angles (from ABangle) | |
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HL | -56.3° |
HC1 | 71.83° |
HC2 | 116.04° |
LC1 | 121.68° |
LC2 | 82.1° |
dc | 15.59Å |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]