Structure Viewer: 6cdi

>   Structure details

Cryo-Em Structure at 3.6 a Resolution of Vaccine-Elicited antibody Vfp16.02 in complex with Hiv-1 Env Bg505 Ds-Sosip, and antibodies Vrc03 and Pgt122

PDB6cdi
SpeciesHOMO SAPIENS
MethodELECTRON MICROSCOPY
Resolution3.6Å
Number of Fvs9
In complexTrue
Light chain typeKappa,unknown
Has constant regionTrue
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>   Fv information

This PDB has 9 Fv(s).

>   m/n
Fv Details
Heavy chainm
Light chainn
Heavy subgroupunknown
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V H L Q E S G P G L V K P S E T L S L T C N V S G T L V R D N Y W S W I R Q P L G K Q P E W I G Y V H D S G D T N Y N P S L K S R V H L S L D K S K N L V S L R L T G V T A A D S A I Y Y C A T T K H G R R I Y G V V A F K E W F T Y F Y M D V W G K G T S V T V S S

Light chain

8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 68A 68B 68C 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
P T F V S V A P G Q T A R I T C G E E S L G S R S V I W Y Q Q R P G Q A P S L I I Y N N N D R P S G I P D R F S G S P G S T F G T T A T L T I T S V E A G D E A D Y Y C H I W D S R R P T N W V F G E G T T L I V L

Antigen Details
Antigen chainsd
Antigen typeprotein
Antigen nameunknown
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceAENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV

CDR Sequences (chothia definition)
CDRH1GTLVRDN
CDRH2HDSGD
CDRH3TKHGRRIYGVVAFKEWFTYFYMDV
CDRL1GEESLGSRSVI
CDRL2NNNDRPS
CDRL3HIWDSRRPTNWV

Orientation Angles (from ABangle)
HL-65.46°
HC175.74°
HC2122.29°
LC1119.36°
LC285.81°
dc16.38Å
>   3/4
Fv Details
Heavy chain3
Light chain4
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L L Q S G A E L V R P G A S V T L S C K A S G Y A F S D Y E I H W V K Q T P V R G L D W I G A F D P K S G A S A S N Q K V K G R A I L T A D K S S S T A Y M E L R S L T S E D S A V Y Y C T R L R Y F G Y F D V W G T G T T V T V S P

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 30D 30E 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D V L M T Q T P L S L P V S L G G Q A S I S C R S S Q S V V Y S D G D T Y L E W Y L Q K P G Q S P K L L I Y K V S R R F S G V P D R F S G S G S G T D F T L K I S R V E T E D L G V Y Y C F Q G S H V P Y T F G G G T K L E I K

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen nameglycoprotein gp41
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceAVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAIEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1GYAFSDY
CDRH2DPKSGA
CDRH3LRYFGYFDV
CDRL1RSSQSVVYSDGDTYLE
CDRL2KVSRRFS
CDRL3FQGSHVPYT

Orientation Angles (from ABangle)
HL-56.91°
HC174.82°
HC2119.29°
LC1123.79°
LC284.07°
dc16.1Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L L Q S G A E L V R P G A S V T L S C K A S G Y A F S D Y E I H W V K Q T P V R G L D W I G A F D P K S G A S A S N Q K V K G R A I L T A D K S S S T A Y M E L R S L T S E D S A V Y Y C T R L R Y F G Y F D V W G T G T T V T V S P

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 30D 30E 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D V L M T Q T P L S L P V S L G G Q A S I S C R S S Q S V V Y S D G D T Y L E W Y L Q K P G Q S P K L L I Y K V S R R F S G V P D R F S G S G S G T D F T L K I S R V E T E D L G V Y Y C F Q G S H V P Y T F G G G T K L E I K

Antigen Details
Antigen chainsD
Antigen typeprotein
Antigen nameglycoprotein 120
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceAVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAIEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1GYAFSDY
CDRH2DPKSGA
CDRH3LRYFGYFDV
CDRL1RSSQSVVYSDGDTYLE
CDRL2KVSRRFS
CDRL3FQGSHVPYT

Orientation Angles (from ABangle)
HL-56.91°
HC174.82°
HC2119.29°
LC1123.79°
LC284.07°
dc16.1Å
>   q/r
Fv Details
Heavy chainq
Light chainr
Heavy subgroupunknown
Light subgroupIGKV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 76A 76B 76C 76D 76E 76F 76G 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V Q S G A V I K T P G S S V K I S C R A S G Y N F R D Y S I H W V R L I P D K G F E W I G W I K P L W G A V S Y A R Q L Q G R V S M T R Q L S Q D P D D P D W G V A Y M E F S G L T P A D T A E Y F C V R R G S C D Y C G D F P W Q Y W G Q G T V V V V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 96 97 98 99 100 101 102 103 104 105 106 107
E I V L T Q S P G I L S L S P G E T A T L F C K A S Q G G N A M T W Y Q K R R G Q V P R L L I Y D T S R R A S G V P D R F V G S G S G T D F F L T I N K L D R E D F A V Y Y C Q Q F E F F G L G S E L E V H

Antigen Details
Antigen chainsd
Antigen typeprotein
Antigen nameunknown
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceAENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV

CDR Sequences (chothia definition)
CDRH1GYNFRDY
CDRH2KPLWGA
CDRH3RGSCDYCGDFPWQY
CDRL1KASQGGNAMT
CDRL2DTSRRAS
CDRL3QQFEF

Orientation Angles (from ABangle)
HL-57.95°
HC175.92°
HC2114.36°
LC1121.81°
LC285.99°
dc16.33Å
>   5/6
Fv Details
Heavy chain5
Light chain6
Heavy subgroupunknown
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V H L Q E S G P G L V K P S E T L S L T C N V S G T L V R D N Y W S W I R Q P L G K Q P E W I G Y V H D S G D T N Y N P S L K S R V H L S L D K S K N L V S L R L T G V T A A D S A I Y Y C A T T K H G R R I Y G V V A F K E W F T Y F Y M D V W G K G T S V T V S S

Light chain

8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 68A 68B 68C 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
P T F V S V A P G Q T A R I T C G E E S L G S R S V I W Y Q Q R P G Q A P S L I I Y N N N D R P S G I P D R F S G S P G S T F G T T A T L T I T S V E A G D E A D Y Y C H I W D S R R P T N W V F G E G T T L I V L

Antigen Details
Antigen chains2
Antigen typeprotein
Antigen nameglycoprotein 120
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceAENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV

CDR Sequences (chothia definition)
CDRH1GTLVRDN
CDRH2HDSGD
CDRH3TKHGRRIYGVVAFKEWFTYFYMDV
CDRL1GEESLGSRSVI
CDRL2NNNDRPS
CDRL3HIWDSRRPTNWV

Orientation Angles (from ABangle)
HL-65.46°
HC175.74°
HC2122.29°
LC1119.36°
LC285.8°
dc16.38Å
>   8/7
Fv Details
Heavy chain8
Light chain7
Heavy subgroupunknown
Light subgroupIGKV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 76A 76B 76C 76D 76E 76F 76G 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V Q S G A V I K T P G S S V K I S C R A S G Y N F R D Y S I H W V R L I P D K G F E W I G W I K P L W G A V S Y A R Q L Q G R V S M T R Q L S Q D P D D P D W G V A Y M E F S G L T P A D T A E Y F C V R R G S C D Y C G D F P W Q Y W G Q G T V V V V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 96 97 98 99 100 101 102 103 104 105 106 107
E I V L T Q S P G I L S L S P G E T A T L F C K A S Q G G N A M T W Y Q K R R G Q V P R L L I Y D T S R R A S G V P D R F V G S G S G T D F F L T I N K L D R E D F A V Y Y C Q Q F E F F G L G S E L E V H

Antigen Details
Antigen chains2
Antigen typeprotein
Antigen nameglycoprotein 120
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceAENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV

CDR Sequences (chothia definition)
CDRH1GYNFRDY
CDRH2KPLWGA
CDRH3RGSCDYCGDFPWQY
CDRL1KASQGGNAMT
CDRL2DTSRRAS
CDRL3QQFEF

Orientation Angles (from ABangle)
HL-57.95°
HC175.92°
HC2114.36°
LC1121.81°
LC285.99°
dc16.33Å
>   M/N
Fv Details
Heavy chainM
Light chainN
Heavy subgroupunknown
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V H L Q E S G P G L V K P S E T L S L T C N V S G T L V R D N Y W S W I R Q P L G K Q P E W I G Y V H D S G D T N Y N P S L K S R V H L S L D K S K N L V S L R L T G V T A A D S A I Y Y C A T T K H G R R I Y G V V A F K E W F T Y F Y M D V W G K G T S V T V S S

Light chain

8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 68A 68B 68C 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
P T F V S V A P G Q T A R I T C G E E S L G S R S V I W Y Q Q R P G Q A P S L I I Y N N N D R P S G I P D R F S G S P G S T F G T T A T L T I T S V E A G D E A D Y Y C H I W D S R R P T N W V F G E G T T L I V L

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen nameglycoprotein 120
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceAENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV

CDR Sequences (chothia definition)
CDRH1GTLVRDN
CDRH2HDSGD
CDRH3TKHGRRIYGVVAFKEWFTYFYMDV
CDRL1GEESLGSRSVI
CDRL2NNNDRPS
CDRL3HIWDSRRPTNWV

Orientation Angles (from ABangle)
HL-65.46°
HC175.74°
HC2122.29°
LC1119.36°
LC285.8°
dc16.38Å
>   h/l
Fv Details
Heavy chainh
Light chainl
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L L Q S G A E L V R P G A S V T L S C K A S G Y A F S D Y E I H W V K Q T P V R G L D W I G A F D P K S G A S A S N Q K V K G R A I L T A D K S S S T A Y M E L R S L T S E D S A V Y Y C T R L R Y F G Y F D V W G T G T T V T V S P

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 30D 30E 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D V L M T Q T P L S L P V S L G G Q A S I S C R S S Q S V V Y S D G D T Y L E W Y L Q K P G Q S P K L L I Y K V S R R F S G V P D R F S G S G S G T D F T L K I S R V E T E D L G V Y Y C F Q G S H V P Y T F G G G T K L E I K

Antigen Details
Antigen chainsc
Antigen typeprotein
Antigen nameunknown
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceAVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAIEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1GYAFSDY
CDRH2DPKSGA
CDRH3LRYFGYFDV
CDRL1RSSQSVVYSDGDTYLE
CDRL2KVSRRFS
CDRL3FQGSHVPYT

Orientation Angles (from ABangle)
HL-56.91°
HC174.82°
HC2119.29°
LC1123.79°
LC284.07°
dc16.1Å
>   Q/R
Fv Details
Heavy chainQ
Light chainR
Heavy subgroupunknown
Light subgroupIGKV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 76A 76B 76C 76D 76E 76F 76G 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V Q S G A V I K T P G S S V K I S C R A S G Y N F R D Y S I H W V R L I P D K G F E W I G W I K P L W G A V S Y A R Q L Q G R V S M T R Q L S Q D P D D P D W G V A Y M E F S G L T P A D T A E Y F C V R R G S C D Y C G D F P W Q Y W G Q G T V V V V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 96 97 98 99 100 101 102 103 104 105 106 107
E I V L T Q S P G I L S L S P G E T A T L F C K A S Q G G N A M T W Y Q K R R G Q V P R L L I Y D T S R R A S G V P D R F V G S G S G T D F F L T I N K L D R E D F A V Y Y C Q Q F E F F G L G S E L E V H

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen nameglycoprotein 120
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceAENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV

CDR Sequences (chothia definition)
CDRH1GYNFRDY
CDRH2KPLWGA
CDRH3RGSCDYCGDFPWQY
CDRL1KASQGGNAMT
CDRL2DTSRRAS
CDRL3QQFEF

Orientation Angles (from ABangle)
HL-57.95°
HC175.92°
HC2114.36°
LC1121.81°
LC285.99°
dc16.33Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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