Structure Viewer: 6chb

> Structure details

Crystal Structure of a Natively-Glycosylated Bg505 Sosip.664 Hiv-1 Envelope Trimer in complex with the Broadly-Neutralizing antibodies Bg18 and Ioma

PDB	6chb
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	6.801Å
Number of Fvs	6
In complex	True
Light chain type	Lambda
Has constant region	True

> Fv information

This PDB has 6 Fv(s).

Fv Details
Heavy chain	J
Light chain	K
Heavy subgroup	unknown
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	R	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	S	C	T	V	S	Q	D	S	R	P	S	D	H	S	W	T	W	V	R	Q	S	P	G	K	A	L	E	W	I	G	D	I	H	Y	N	G	A	T	T	Y	N	P	S	L	R	S	R	V	R	I	E	L	D	Q	S	I	P	R	F	S	L	K	M	T	S	M	T	A	A	D	T	G	M	Y	Y	C	A	R	N	A	I	R	I	Y	G	V	V	A	L	G	E	W	F	H	Y	G	M	D	V	W	G	Q	G	T	A	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	S	E	L	T	Q	P	P	S	V	S	V	S	P	G	Q	T	A	R	I	T	C	S	G	A	P	L	T	S	R	F	T	Y	W	Y	R	Q	K	P	G	Q	A	P	V	L	I	I	S	R	S	S	Q	R	S	S	G	W	S	G	R	F	S	A	S	W	S	G	T	T	V	T	L	T	I	R	G	V	Q	A	D	D	E	A	D	Y	Y	C	Q	S	S	D	T	S	D	S	Y	K	M	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	G
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGREKR

CDR Sequences (chothia definition)
CDRH1	QDSRPSDH
CDRH2	HYNGA
CDRH3	NAIRIYGVVALGEWFHYGMDV
CDRL1	SGAPLTSRFTY
CDRL2	RSSQRSS
CDRL3	QSSDTSDSYKM

Orientation Angles (from ABangle)
HL	-49.4°
HC1	72.87°
HC2	122.33°
LC1	118.83°
LC2	89.03°
dc	16.71Å

Fv Details
Heavy chain	M
Light chain	N
Heavy subgroup	IGHV1
Light subgroup	IGLV2
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	A	Q	V	K	K	P	G	A	S	V	T	V	S	C	T	A	S	G	Y	K	F	T	G	Y	H	M	H	W	V	R	Q	A	P	G	R	G	L	E	W	M	G	W	I	N	P	F	R	G	A	V	K	Y	P	Q	N	F	R	G	R	V	S	M	T	R	D	T	S	M	E	I	F	Y	M	E	L	S	R	L	T	S	D	D	T	A	V	Y	Y	C	A	R	E	M	F	D	S	S	A	D	W	S	P	W	R	G	M	V	A	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	A	L	T	Q	P	A	S	V	S	G	S	P	G	Q	S	I	T	I	S	C	A	G	S	S	R	D	V	G	G	F	D	L	V	S	W	Y	Q	Q	H	P	G	K	A	P	K	L	I	I	Y	E	V	N	K	R	P	S	G	I	S	S	R	F	S	A	S	K	S	G	N	T	A	S	L	T	I	S	G	L	Q	E	E	D	E	A	H	Y	Y	C	Y	S	Y	A	D	G	V	A	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	F
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGREKR

CDR Sequences (chothia definition)
CDRH1	GYKFTGY
CDRH2	NPFRGA
CDRH3	EMFDSSADWSPWRGMVA
CDRL1	AGSSRDVGGFDLVS
CDRL2	EVNKRPS
CDRL3	YSYADGVA

Orientation Angles (from ABangle)
HL	-55.36°
HC1	71.32°
HC2	112.83°
LC1	128.39°
LC2	79.28°
dc	16.55Å

Fv Details
Heavy chain	I
Light chain	L
Heavy subgroup	unknown
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	R	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	S	C	T	V	S	Q	D	S	R	P	S	D	H	S	W	T	W	V	R	Q	S	P	G	K	A	L	E	W	I	G	D	I	H	Y	N	G	A	T	T	Y	N	P	S	L	R	S	R	V	R	I	E	L	D	Q	S	I	P	R	F	S	L	K	M	T	S	M	T	A	A	D	T	G	M	Y	Y	C	A	R	N	A	I	R	I	Y	G	V	V	A	L	G	E	W	F	H	Y	G	M	D	V	W	G	Q	G	T	A	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	S	E	L	T	Q	P	P	S	V	S	V	S	P	G	Q	T	A	R	I	T	C	S	G	A	P	L	T	S	R	F	T	Y	W	Y	R	Q	K	P	G	Q	A	P	V	L	I	I	S	R	S	S	Q	R	S	S	G	W	S	G	R	F	S	A	S	W	S	G	T	T	V	T	L	T	I	R	G	V	Q	A	D	D	E	A	D	Y	Y	C	Q	S	S	D	T	S	D	S	Y	K	M	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	F
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGREKR

CDR Sequences (chothia definition)
CDRH1	QDSRPSDH
CDRH2	HYNGA
CDRH3	NAIRIYGVVALGEWFHYGMDV
CDRL1	SGAPLTSRFTY
CDRL2	RSSQRSS
CDRL3	QSSDTSDSYKM

Orientation Angles (from ABangle)
HL	-56.2°
HC1	71.13°
HC2	124.06°
LC1	119.99°
LC2	83.0°
dc	16.57Å

Fv Details
Heavy chain	Q
Light chain	R
Heavy subgroup	unknown
Light subgroup	IGLV3
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	R	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	S	C	T	V	S	Q	D	S	R	P	S	D	H	S	W	T	W	V	R	Q	S	P	G	K	A	L	E	W	I	G	D	I	H	Y	N	G	A	T	T	Y	N	P	S	L	R	S	R	V	R	I	E	L	D	Q	S	I	P	R	F	S	L	K	M	T	S	M	T	A	A	D	T	G	M	Y	Y	C	A	R	N	A	I	R	I	Y	G	V	V	A	L	G	E	W	F	H	Y	G	M	D	V	W	G	Q	G	T	A	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
S	S	E	L	T	Q	P	P	S	V	S	V	S	P	G	Q	T	A	R	I	T	C	S	G	A	P	L	T	S	R	F	T	Y	W	Y	R	Q	K	P	G	Q	A	P	V	L	I	I	S	R	S	S	Q	R	S	S	G	W	S	G	R	F	S	A	S	W	S	G	T	T	V	T	L	T	I	R	G	V	Q	A	D	D	E	A	D	Y	Y	C	Q	S	S	D	T	S	D	S	Y	K	M	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	H
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGREKR

CDR Sequences (chothia definition)
CDRH1	QDSRPSDH
CDRH2	HYNGA
CDRH3	NAIRIYGVVALGEWFHYGMDV
CDRL1	SGAPLTSRFTY
CDRL2	RSSQRSS
CDRL3	QSSDTSDSYKM

Orientation Angles (from ABangle)
HL	-55.99°
HC1	72.75°
HC2	121.9°
LC1	114.55°
LC2	85.97°
dc	17.01Å

Fv Details
Heavy chain	O
Light chain	P
Heavy subgroup	IGHV1
Light subgroup	IGLV2
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	A	Q	V	K	K	P	G	A	S	V	T	V	S	C	T	A	S	G	Y	K	F	T	G	Y	H	M	H	W	V	R	Q	A	P	G	R	G	L	E	W	M	G	W	I	N	P	F	R	G	A	V	K	Y	P	Q	N	F	R	G	R	V	S	M	T	R	D	T	S	M	E	I	F	Y	M	E	L	S	R	L	T	S	D	D	T	A	V	Y	Y	C	A	R	E	M	F	D	S	S	A	D	W	S	P	W	R	G	M	V	A	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	A	L	T	Q	P	A	S	V	S	G	S	P	G	Q	S	I	T	I	S	C	A	G	S	S	R	D	V	G	G	F	D	L	V	S	W	Y	Q	Q	H	P	G	K	A	P	K	L	I	I	Y	E	V	N	K	R	P	S	G	I	S	S	R	F	S	A	S	K	S	G	N	T	A	S	L	T	I	S	G	L	Q	E	E	D	E	A	H	Y	Y	C	Y	S	Y	A	D	G	V	A	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	H
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGREKR

CDR Sequences (chothia definition)
CDRH1	GYKFTGY
CDRH2	NPFRGA
CDRH3	EMFDSSADWSPWRGMVA
CDRL1	AGSSRDVGGFDLVS
CDRL2	EVNKRPS
CDRL3	YSYADGVA

Orientation Angles (from ABangle)
HL	-61.36°
HC1	79.37°
HC2	119.58°
LC1	118.46°
LC2	84.4°
dc	16.18Å

Fv Details
Heavy chain	D
Light chain	E
Heavy subgroup	IGHV1
Light subgroup	IGLV2
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	A	Q	V	K	K	P	G	A	S	V	T	V	S	C	T	A	S	G	Y	K	F	T	G	Y	H	M	H	W	V	R	Q	A	P	G	R	G	L	E	W	M	G	W	I	N	P	F	R	G	A	V	K	Y	P	Q	N	F	R	G	R	V	S	M	T	R	D	T	S	M	E	I	F	Y	M	E	L	S	R	L	T	S	D	D	T	A	V	Y	Y	C	A	R	E	M	F	D	S	S	A	D	W	S	P	W	R	G	M	V	A	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	A	L	T	Q	P	A	S	V	S	G	S	P	G	Q	S	I	T	I	S	C	A	G	S	S	R	D	V	G	G	F	D	L	V	S	W	Y	Q	Q	H	P	G	K	A	P	K	L	I	I	Y	E	V	N	K	R	P	S	G	I	S	S	R	F	S	A	S	K	S	G	N	T	A	S	L	T	I	S	G	L	Q	E	E	D	E	A	H	Y	Y	C	Y	S	Y	A	D	G	V	A	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	G
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGREKR

CDR Sequences (chothia definition)
CDRH1	GYKFTGY
CDRH2	NPFRGA
CDRH3	EMFDSSADWSPWRGMVA
CDRL1	AGSSRDVGGFDLVS
CDRL2	EVNKRPS
CDRL3	YSYADGVA

Orientation Angles (from ABangle)
HL	-53.41°
HC1	77.87°
HC2	112.25°
LC1	112.17°
LC2	85.31°
dc	15.7Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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