Structure Viewer: 6gjq

>   Structure details

Human Nbd1 of Cftr in complex with Nanobody T27

PDB6gjq
SpeciesLAMA GLAMA
MethodX-RAY DIFFRACTION
Resolution2.49Å
Number of Fvs4
In complexTrue
Light chain type
Has constant regionFalse
>   Structure visualisation
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>   Fv information

This PDB has 4 Fv(s).

>   F/-
Fv Details
Heavy chainF
Light chain
Heavy subgroupIGHV1
Light subgroup
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L E Q P G G S L R L S C A T S G V I F G I N A M G W Y R Q A P G K Q R E L V A T F T S G G S T N Y A D F V E G R F T I S R D N A K N T V Y L Q M N G L R P E D T A V Y Y C H A T V V V S R Y G L T Y D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namecystic fibrosis transmembrane conductance regulator
Antigen speciesHOMO SAPIENS
Antigen sequenceSLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCPQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFPEKDNTVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMG

CDR Sequences (chothia definition)
CDRH1GVIFGIN
CDRH2TSGGS
CDRH3TVVVSRYGLTYDY

>   D/-
Fv Details
Heavy chainD
Light chain
Heavy subgroupIGHV1
Light subgroup
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L E Q P G G S L R L S C A T S G V I F G I N A M G W Y R Q A P G K Q R E L V A T F T S G G S T N Y A D F V E G R F T I S R D N A K N T V Y L Q M N G L R P E D T A V Y Y C H A T V V V S R Y G L T Y D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namecystic fibrosis transmembrane conductance regulator
Antigen speciesHOMO SAPIENS
Antigen sequenceSLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCPQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFPEKDNTVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMG

CDR Sequences (chothia definition)
CDRH1GVIFGIN
CDRH2TSGGS
CDRH3TVVVSRYGLTYDY

>   B/-
Fv Details
Heavy chainB
Light chain
Heavy subgroupIGHV1
Light subgroup
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L E Q P G G S L R L S C A T S G V I F G I N A M G W Y R Q A P G K Q R E L V A T F T S G G S T N Y A D F V E G R F T I S R D N A K N T V Y L Q M N G L R P E D T A V Y Y C H A T V V V S R Y G L T Y D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namecystic fibrosis transmembrane conductance regulator
Antigen speciesHOMO SAPIENS
Antigen sequenceSLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCPQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFPEKDNTVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMG

CDR Sequences (chothia definition)
CDRH1GVIFGIN
CDRH2TSGGS
CDRH3TVVVSRYGLTYDY

>   H/-
Fv Details
Heavy chainH
Light chain
Heavy subgroupIGHV1
Light subgroup
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L E Q P G G S L R L S C A T S G V I F G I N A M G W Y R Q A P G K Q R E L V A T F T S G G S T N Y A D F V E G R F T I S R D N A K N T V Y L Q M N G L R P E D T A V Y Y C H A T V V V S R Y G L T Y D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsG
Antigen typeprotein
Antigen namecystic fibrosis transmembrane conductance regulator
Antigen speciesHOMO SAPIENS
Antigen sequenceSLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCPQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFPEKDNTVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMG

CDR Sequences (chothia definition)
CDRH1GVIFGIN
CDRH2TSGGS
CDRH3TVVVSRYGLTYDY

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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