Structure Viewer: 6p4b

>   Structure details

Hyhel10 Fab Variant Hyhel10-4X (Heavy Chain Mutations L4F, Y33H, S56N, and Y58F) Bound to Hen Egg Lysozyme Variant Hel2X-Flex (Mutations R21Q, R73E, C76S, and C94S)

PDB6p4b
SpeciesMUS MUSCULUS
MethodX-RAY DIFFRACTION
Resolution1.9Å
Number of Fvs2
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   B/A
Fv Details
Heavy chainB
Light chainA
Heavy subgroupIGHV3
Light subgroupIGKV5
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 101 102 103 104 105 106 107 108 109 110 111 112 113
D V Q F Q E S G P S L V K P S Q T L S L T C S V T G D S I T S D H W S W I R K F P G N R L E Y M G Y V S Y S G N T F Y N P S L K S R I S I T R D T S K N Q Y Y L D L N S V T T E D T A T Y Y C A N W D G D Y W G Q G T L V T V S A

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I V L T Q S P A T L S V T P G N S V S L S C R A S Q S I G N N L H W Y Q Q K S H E S P R L L I K Y A S Q S I S G I P S R F S G S G S G T D F T L S I N S V E T E D F G M Y F C Q Q S N S W P Y T F G G G T K L E I K

Antigen Details
Antigen chainsD
Antigen typeprotein
Antigen namelysozyme c
Antigen speciesGALLUS GALLUS
Antigen sequenceKVFGRCELAAAMKRHGLDNYQGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSENLSNIPCSALLSSDITASVNSAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL

CDR Sequences (chothia definition)
CDRH1GDSITSD
CDRH2SYSGN
CDRH3WDGDY
CDRL1RASQSIGNNLH
CDRL2YASQSIS
CDRL3QQSNSWPYT

Orientation Angles (from ABangle)
HL-55.7°
HC171.81°
HC2116.22°
LC1120.31°
LC285.91°
dc16.12Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV3
Light subgroupIGKV5
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 101 102 103 104 105 106 107 108 109 110 111 112 113
D V Q F Q E S G P S L V K P S Q T L S L T C S V T G D S I T S D H W S W I R K F P G N R L E Y M G Y V S Y S G N T F Y N P S L K S R I S I T R D T S K N Q Y Y L D L N S V T T E D T A T Y Y C A N W D G D Y W G Q G T L V T V S A

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I V L T Q S P A T L S V T P G N S V S L S C R A S Q S I G N N L H W Y Q Q K S H E S P R L L I K Y A S Q S I S G I P S R F S G S G S G T D F T L S I N S V E T E D F G M Y F C Q Q S N S W P Y T F G G G T K L E I K

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namelysozyme c
Antigen speciesGALLUS GALLUS
Antigen sequenceKVFGRCELAAAMKRHGLDNYQGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSENLSNIPCSALLSSDITASVNSAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL

CDR Sequences (chothia definition)
CDRH1GDSITSD
CDRH2SYSGN
CDRH3WDGDY
CDRL1RASQSIGNNLH
CDRL2YASQSIS
CDRL3QQSNSWPYT

Orientation Angles (from ABangle)
HL-56.63°
HC173.75°
HC2118.5°
LC1119.13°
LC284.24°
dc15.93Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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