Structure Viewer: 6qn8

> Structure details

Structure of Bovine anti-Rsv Fab B13

PDB	6qn8
Species	BOS TAURUS
Method	X-RAY DIFFRACTION
Resolution	2.12Å
Number of Fvs	6
In complex	True
Light chain type	Lambda
Has constant region	True

> Fv information

This PDB has 6 Fv(s).

Fv Details
Heavy chain	E
Light chain	F
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	100Q	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	L	S	L	S	D	H	N	V	G	W	I	R	Q	A	P	G	K	A	L	E	W	L	G	V	I	Y	K	E	G	D	K	D	Y	N	P	A	L	K	S	R	L	S	I	T	K	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	E	D	T	A	T	Y	Y	C	A	T	L	G	C	Y	F	V	E	G	V	G	Y	D	C	T	Y	G	L	Q	H	T	T	F	H	D	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	L	T	Q	P	P	S	V	S	G	S	L	G	Q	R	V	S	I	T	C	S	G	S	S	D	N	I	G	I	F	A	V	G	W	Y	Q	Q	V	P	G	S	G	L	R	T	I	I	Y	G	N	T	K	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	N	T	A	T	L	T	I	N	S	L	Q	A	E	D	E	A	D	Y	F	C	V	C	G	E	S	K	S	A	T	P	V	F	G	G	G	T	T	L	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GLSLSDH
CDRH2	YKEGD
CDRH3	LGCYFVEGVGYDCTYGLQHTTFHDA
CDRL1	SGSSDNIGIFAVG
CDRL2	GNTKRPS
CDRL3	VCGESKSATPV

Orientation Angles (from ABangle)
HL	-58.6°
HC1	74.27°
HC2	114.75°
LC1	116.78°
LC2	87.0°
dc	15.83Å

Fv Details
Heavy chain	C
Light chain	D
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	100Q	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	L	S	L	S	D	H	N	V	G	W	I	R	Q	A	P	G	K	A	L	E	W	L	G	V	I	Y	K	E	G	D	K	D	Y	N	P	A	L	K	S	R	L	S	I	T	K	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	E	D	T	A	T	Y	Y	C	A	T	L	G	C	Y	F	V	E	G	V	G	Y	D	C	T	Y	G	L	Q	H	T	T	F	H	D	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	L	T	Q	P	P	S	V	S	G	S	L	G	Q	R	V	S	I	T	C	S	G	S	S	D	N	I	G	I	F	A	V	G	W	Y	Q	Q	V	P	G	S	G	L	R	T	I	I	Y	G	N	T	K	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	N	T	A	T	L	T	I	N	S	L	Q	A	E	D	E	A	D	Y	F	C	V	C	G	E	S	K	S	A	T	P	V	F	G	G	G	T	T	L	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GLSLSDH
CDRH2	YKEGD
CDRH3	LGCYFVEGVGYDCTYGLQHTTFHDA
CDRL1	SGSSDNIGIFAVG
CDRL2	GNTKRPS
CDRL3	VCGESKSATPV

Orientation Angles (from ABangle)
HL	-57.1°
HC1	73.69°
HC2	113.39°
LC1	118.18°
LC2	86.86°
dc	15.76Å

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	100Q	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	L	S	L	S	D	H	N	V	G	W	I	R	Q	A	P	G	K	A	L	E	W	L	G	V	I	Y	K	E	G	D	K	D	Y	N	P	A	L	K	S	R	L	S	I	T	K	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	E	D	T	A	T	Y	Y	C	A	T	L	G	C	Y	F	V	E	G	V	G	Y	D	C	T	Y	G	L	Q	H	T	T	F	H	D	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	L	T	Q	P	P	S	V	S	G	S	L	G	Q	R	V	S	I	T	C	S	G	S	S	D	N	I	G	I	F	A	V	G	W	Y	Q	Q	V	P	G	S	G	L	R	T	I	I	Y	G	N	T	K	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	N	T	A	T	L	T	I	N	S	L	Q	A	E	D	E	A	D	Y	F	C	V	C	G	E	S	K	S	A	T	P	V	F	G	G	G	T	T	L	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GLSLSDH
CDRH2	YKEGD
CDRH3	LGCYFVEGVGYDCTYGLQHTTFHDA
CDRL1	SGSSDNIGIFAVG
CDRL2	GNTKRPS
CDRL3	VCGESKSATPV

Orientation Angles (from ABangle)
HL	-57.17°
HC1	73.99°
HC2	114.83°
LC1	118.8°
LC2	88.0°
dc	15.77Å

Fv Details
Heavy chain	G
Light chain	I
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	100Q	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	L	S	L	S	D	H	N	V	G	W	I	R	Q	A	P	G	K	A	L	E	W	L	G	V	I	Y	K	E	G	D	K	D	Y	N	P	A	L	K	S	R	L	S	I	T	K	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	E	D	T	A	T	Y	Y	C	A	T	L	G	C	Y	F	V	E	G	V	G	Y	D	C	T	Y	G	L	Q	H	T	T	F	H	D	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	L	T	Q	P	P	S	V	S	G	S	L	G	Q	R	V	S	I	T	C	S	G	S	S	D	N	I	G	I	F	A	V	G	W	Y	Q	Q	V	P	G	S	G	L	R	T	I	I	Y	G	N	T	K	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	N	T	A	T	L	T	I	N	S	L	Q	A	E	D	E	A	D	Y	F	C	V	C	G	E	S	K	S	A	T	P	V	F	G	G	G	T	T	L	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GLSLSDH
CDRH2	YKEGD
CDRH3	LGCYFVEGVGYDCTYGLQHTTFHDA
CDRL1	SGSSDNIGIFAVG
CDRL2	GNTKRPS
CDRL3	VCGESKSATPV

Orientation Angles (from ABangle)
HL	-57.04°
HC1	73.96°
HC2	114.13°
LC1	116.92°
LC2	87.34°
dc	15.95Å

Fv Details
Heavy chain	A
Light chain	B
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	100Q	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	L	S	L	S	D	H	N	V	G	W	I	R	Q	A	P	G	K	A	L	E	W	L	G	V	I	Y	K	E	G	D	K	D	Y	N	P	A	L	K	S	R	L	S	I	T	K	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	E	D	T	A	T	Y	Y	C	A	T	L	G	C	Y	F	V	E	G	V	G	Y	D	C	T	Y	G	L	Q	H	T	T	F	H	D	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	L	T	Q	P	P	S	V	S	G	S	L	G	Q	R	V	S	I	T	C	S	G	S	S	D	N	I	G	I	F	A	V	G	W	Y	Q	Q	V	P	G	S	G	L	R	T	I	I	Y	G	N	T	K	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	N	T	A	T	L	T	I	N	S	L	Q	A	E	D	E	A	D	Y	F	C	V	C	G	E	S	K	S	A	T	P	V	F	G	G	G	T	T	L	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GLSLSDH
CDRH2	YKEGD
CDRH3	LGCYFVEGVGYDCTYGLQHTTFHDA
CDRL1	SGSSDNIGIFAVG
CDRL2	GNTKRPS
CDRL3	VCGESKSATPV

Orientation Angles (from ABangle)
HL	-57.08°
HC1	73.18°
HC2	113.66°
LC1	118.81°
LC2	87.99°
dc	15.95Å

Fv Details
Heavy chain	J
Light chain	K
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	BOS TAURUS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	100Q	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	S	L	V	K	P	S	Q	T	L	S	L	T	C	T	V	S	G	L	S	L	S	D	H	N	V	G	W	I	R	Q	A	P	G	K	A	L	E	W	L	G	V	I	Y	K	E	G	D	K	D	Y	N	P	A	L	K	S	R	L	S	I	T	K	D	N	S	K	S	Q	V	S	L	S	L	S	S	V	T	T	E	D	T	A	T	Y	Y	C	A	T	L	G	C	Y	F	V	E	G	V	G	Y	D	C	T	Y	G	L	Q	H	T	T	F	H	D	A	W	G	Q	G	L	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	A	V	L	T	Q	P	P	S	V	S	G	S	L	G	Q	R	V	S	I	T	C	S	G	S	S	D	N	I	G	I	F	A	V	G	W	Y	Q	Q	V	P	G	S	G	L	R	T	I	I	Y	G	N	T	K	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	N	T	A	T	L	T	I	N	S	L	Q	A	E	D	E	A	D	Y	F	C	V	C	G	E	S	K	S	A	T	P	V	F	G	G	G	T	T	L	T	V	L

Antigen Details
Antigen chains
Antigen type
Antigen name
Antigen species	SYNTHETIC CONSTRUCT
Antigen sequence

CDR Sequences (chothia definition)
CDRH1	GLSLSDH
CDRH2	YKEGD
CDRH3	LGCYFVEGVGYDCTYGLQHTTFHDA
CDRL1	SGSSDNIGIFAVG
CDRL2	GNTKRPS
CDRL3	VCGESKSATPV

Orientation Angles (from ABangle)
HL	-55.41°
HC1	73.99°
HC2	114.06°
LC1	119.4°
LC2	87.34°
dc	15.79Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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