Structure Viewer: 6vmk

>   Structure details

Crystal Structure of Human Complement Factor D with anti-Factor D Fab 20D12

PDB6vmk
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution3.01Å
Number of Fvs16
In complexTrue
Light chain typeKappa
Has constant regionTrue
>   Structure visualisation
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>   Fv information

This PDB has 16 Fv(s).

>   l/k
Fv Details
Heavy chainl
Light chaink
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsm
Antigen typeprotein
Antigen nameunknown
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-54.57°
HC171.42°
HC2116.98°
LC1120.31°
LC284.95°
dc15.79Å
>   M/L
Fv Details
Heavy chainM
Light chainL
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsW
Antigen typeprotein
Antigen namecomplement factor d
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-57.81°
HC171.91°
HC2115.25°
LC1118.76°
LC284.64°
dc15.71Å
>   E/D
Fv Details
Heavy chainE
Light chainD
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsF
Antigen typeprotein
Antigen namefab y49r heavy chain
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-55.64°
HC171.33°
HC2116.82°
LC1119.21°
LC284.96°
dc15.81Å
>   Z/Y
Fv Details
Heavy chainZ
Light chainY
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsa
Antigen typeprotein
Antigen nameunknown
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-54.41°
HC171.36°
HC2116.79°
LC1120.42°
LC285.61°
dc15.75Å
>   i/h
Fv Details
Heavy chaini
Light chainh
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsj
Antigen typeprotein
Antigen nameunknown
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-55.69°
HC171.52°
HC2116.99°
LC1119.33°
LC284.3°
dc15.7Å
>   u/t
Fv Details
Heavy chainu
Light chaint
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsv
Antigen typeprotein
Antigen nameunknown
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-55.34°
HC171.43°
HC2116.5°
LC1120.65°
LC285.15°
dc15.65Å
>   c/b
Fv Details
Heavy chainc
Light chainb
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsd
Antigen typeprotein
Antigen nameunknown
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-54.6°
HC171.66°
HC2116.27°
LC1120.34°
LC285.71°
dc15.69Å
>   o/n
Fv Details
Heavy chaino
Light chainn
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsp
Antigen typeprotein
Antigen nameunknown
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-54.92°
HC171.47°
HC2117.39°
LC1120.27°
LC284.98°
dc15.76Å
>   r/q
Fv Details
Heavy chainr
Light chainq
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainss
Antigen typeprotein
Antigen nameunknown
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-55.29°
HC171.79°
HC2116.84°
LC1119.96°
LC285.57°
dc15.74Å
>   K/J
Fv Details
Heavy chainK
Light chainJ
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsN
Antigen typeprotein
Antigen namefab y49r light chain
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-56.5°
HC171.46°
HC2116.65°
LC1119.02°
LC284.26°
dc15.74Å
>   B/A
Fv Details
Heavy chainB
Light chainA
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namefab y49r heavy chain
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-58.34°
HC171.95°
HC2115.28°
LC1118.09°
LC284.44°
dc15.72Å
>   f/e
Fv Details
Heavy chainf
Light chaine
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsg
Antigen typeprotein
Antigen nameunknown
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-55.69°
HC171.45°
HC2116.86°
LC1119.19°
LC284.23°
dc15.77Å
>   V/U
Fv Details
Heavy chainV
Light chainU
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsX
Antigen typeprotein
Antigen namecomplement factor d
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-57.76°
HC171.76°
HC2115.93°
LC1118.11°
LC284.46°
dc15.71Å
>   P/O
Fv Details
Heavy chainP
Light chainO
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsQ
Antigen typeprotein
Antigen namefab y49r light chain
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-55.98°
HC171.41°
HC2116.52°
LC1119.45°
LC284.71°
dc15.77Å
>   S/R
Fv Details
Heavy chainS
Light chainR
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsT
Antigen typeprotein
Antigen namefab y49r light chain
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-56.25°
HC171.62°
HC2116.37°
LC1118.85°
LC284.89°
dc15.81Å
>   H/G
Fv Details
Heavy chainH
Light chainG
Heavy subgroupIGHV1
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y Y M Y W V R Q A P G Q G L E W I G E I N P T S G G T N F N E K F K S R A T L T V D T S T S T A Y L E L S S L R S E D T A V Y Y C A R E G G F A Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q N V D T D V A W F Q Q K P G K A P K G L I R S A S S R Y S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q Y N N Y P L T F G Q G T K V E I K

Antigen Details
Antigen chainsI
Antigen typeprotein
Antigen namefab y49r heavy chain
Antigen speciesHOMO SAPIENS
Antigen sequenceILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPTSGG
CDRH3EGGFAY
CDRL1KASQNVDTDVA
CDRL2SASSRYS
CDRL3QQYNNYPLT

Orientation Angles (from ABangle)
HL-55.37°
HC171.32°
HC2117.03°
LC1120.14°
LC285.42°
dc15.77Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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