Structure Viewer: 6x9x

>   Structure details

Crystal Structure of Fab Fragment of anti-Hcv E2 antibody (Hc84.26)

PDB6x9x
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution1.8Å
Number of Fvs2
In complexFalse
Light chain typeNA,Lambda
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   -/B
Fv Details
Heavy chain
Light chainB
Heavy subgroupNA
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
S Y V L T Q P P S V S V A P G Q T A S I T C S G D K L G D K Y V S W Y Q Q R P G Q S P V L V L Y Q D S K R P S G I P E R F S G S N S G N T A T L T I S G T Q A M D E A D Y Y C Q A W D S S A L V F G G G T K L T V L


CDR Sequences (chothia definition)
CDRL1SGDKLGDKYVS
CDRL2QDSKRPS
CDRL3QAWDSSALV

>   A/-
Fv Details
Heavy chainA
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q P V Q S G A E V K K P G S S V K V S C E A S G G T H S N Y V I T W V R Q A P G Q G L E W M G G F I P D F R T A M Y A Q G F Q G R V T I T A D E S T S L A Y M E L T N L R S E D T A V Y Y C A R G P L S R G Y Y D Y W G P G T L V T V S A


CDR Sequences (chothia definition)
CDRH1GGTHSNY
CDRH2IPDFRT
CDRH3GPLSRGYYDY

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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