Structure Viewer: 7lx3

>   Structure details

Cryo-Em Structure of Edc-Crosslinked Consosl.Ufo.664 (Cons-Edc) in complex with Bnab Pgt122

PDB7lx3
SpeciesHOMO SAPIENS
MethodELECTRON MICROSCOPY
Resolution3.45Å
Number of Fvs3
In complexTrue
Light chain typeunknown
Has constant regionTrue
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>   Fv information

This PDB has 3 Fv(s).

>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV4
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V H L Q E S G P G L V K P S E T L S L T C N V S G T L V R D N Y W S W I R Q P L G K Q P E W I G Y V H D S G D T N Y N P S L K S R V H L S L D K S K N L V S L R L T G V T A A D S A I Y Y C A T T K H G R R I Y G V V A F K E W F T Y F Y M D V W G K G T S V T V S S

Light chain

9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 68A 68B 68C 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
T F V S V A P G Q T A R I T C G E E S L G S R S V I W Y Q Q R P G Q A P S L I I Y N N N D R P S G I P D R F S G S P G S T F G T T A T L T I T S V E A G D E A D Y Y C H I W D S R R P T N W V F G E G T T L I V L

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen nameenv glycoprotein gp160
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceMDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSRVENLWVTVYYGVPVWKDAETTLFCASDAKAYDTEKRNVWATHACVPTDPNPQEIVLENVTENFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLNCTNVNVTNTTNNTEEKGEIKNCSFNITTELRDKKKKVYALFYRLDVVPIDDNNNNSSNYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGTGPCKNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENITNNAKTIIVQLNESVEINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNISGTKWNKTLQQVVKKLREHFNNKTIIFNPSSGGDLEITTHSFNCGGEFFYCNTSGLFNSTWIGNGTKNNNNTNDTITLPCRIKQIINMWQRVGQPMYAPPIQGKIRCVSNITGLLLTRDGGNNNTNETETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVEGGGGGSGGGGSAVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGGSGSGSGSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNKSQDEIWDNMTWMEWDKEINNYTDIIYSLIEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1GTLVRDN
CDRH2HDSGD
CDRH3TKHGRRIYGVVAFKEWFTYFYMDV
CDRL1GEESLGSRSVI
CDRL2NNNDRPS
CDRL3HIWDSRRPTNWV

Orientation Angles (from ABangle)
HL-65.82°
HC174.22°
HC2122.32°
LC1119.99°
LC284.17°
dc16.23Å
>   N/M
Fv Details
Heavy chainN
Light chainM
Heavy subgroupIGHV4
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V H L Q E S G P G L V K P S E T L S L T C N V S G T L V R D N Y W S W I R Q P L G K Q P E W I G Y V H D S G D T N Y N P S L K S R V H L S L D K S K N L V S L R L T G V T A A D S A I Y Y C A T T K H G R R I Y G V V A F K E W F T Y F Y M D V W G K G T S V T V S S

Light chain

9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 68A 68B 68C 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
T F V S V A P G Q T A R I T C G E E S L G S R S V I W Y Q Q R P G Q A P S L I I Y N N N D R P S G I P D R F S G S P G S T F G T T A T L T I T S V E A G D E A D Y Y C H I W D S R R P T N W V F G E G T T L I V L

Antigen Details
Antigen chainsB
Antigen typeprotein
Antigen nameenv glycoprotein gp160
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceMDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSRVENLWVTVYYGVPVWKDAETTLFCASDAKAYDTEKRNVWATHACVPTDPNPQEIVLENVTENFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLNCTNVNVTNTTNNTEEKGEIKNCSFNITTELRDKKKKVYALFYRLDVVPIDDNNNNSSNYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGTGPCKNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENITNNAKTIIVQLNESVEINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNISGTKWNKTLQQVVKKLREHFNNKTIIFNPSSGGDLEITTHSFNCGGEFFYCNTSGLFNSTWIGNGTKNNNNTNDTITLPCRIKQIINMWQRVGQPMYAPPIQGKIRCVSNITGLLLTRDGGNNNTNETETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVEGGGGGSGGGGSAVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGGSGSGSGSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNKSQDEIWDNMTWMEWDKEINNYTDIIYSLIEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1GTLVRDN
CDRH2HDSGD
CDRH3TKHGRRIYGVVAFKEWFTYFYMDV
CDRL1GEESLGSRSVI
CDRL2NNNDRPS
CDRL3HIWDSRRPTNWV

Orientation Angles (from ABangle)
HL-66.02°
HC174.37°
HC2122.48°
LC1119.63°
LC284.03°
dc16.18Å
>   P/O
Fv Details
Heavy chainP
Light chainO
Heavy subgroupIGHV4
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V H L Q E S G P G L V K P S E T L S L T C N V S G T L V R D N Y W S W I R Q P L G K Q P E W I G Y V H D S G D T N Y N P S L K S R V H L S L D K S K N L V S L R L T G V T A A D S A I Y Y C A T T K H G R R I Y G V V A F K E W F T Y F Y M D V W G K G T S V T V S S

Light chain

9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 68A 68B 68C 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
T F V S V A P G Q T A R I T C G E E S L G S R S V I W Y Q Q R P G Q A P S L I I Y N N N D R P S G I P D R F S G S P G S T F G T T A T L T I T S V E A G D E A D Y Y C H I W D S R R P T N W V F G E G T T L I V L

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen nameenv glycoprotein gp160
Antigen speciesHUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequenceMDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSRVENLWVTVYYGVPVWKDAETTLFCASDAKAYDTEKRNVWATHACVPTDPNPQEIVLENVTENFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLNCTNVNVTNTTNNTEEKGEIKNCSFNITTELRDKKKKVYALFYRLDVVPIDDNNNNSSNYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGTGPCKNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENITNNAKTIIVQLNESVEINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNISGTKWNKTLQQVVKKLREHFNNKTIIFNPSSGGDLEITTHSFNCGGEFFYCNTSGLFNSTWIGNGTKNNNNTNDTITLPCRIKQIINMWQRVGQPMYAPPIQGKIRCVSNITGLLLTRDGGNNNTNETETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVEGGGGGSGGGGSAVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGGSGSGSGSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNKSQDEIWDNMTWMEWDKEINNYTDIIYSLIEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1GTLVRDN
CDRH2HDSGD
CDRH3TKHGRRIYGVVAFKEWFTYFYMDV
CDRL1GEESLGSRSVI
CDRL2NNNDRPS
CDRL3HIWDSRRPTNWV

Orientation Angles (from ABangle)
HL-66.07°
HC174.33°
HC2122.44°
LC1120.06°
LC283.92°
dc16.23Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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