Structure Viewer: 7o85

> Structure details

anthrax toxin Prepore in complex with the Neutralizing Fab Cab29

PDB	7o85
Species	MUS MUSCULUS
Method	ELECTRON MICROSCOPY
Resolution	3.3Å
Number of Fvs	7
In complex	True
Light chain type	unknown
Has constant region	False

> Fv information

This PDB has 7 Fv(s).

Fv Details
Heavy chain
Light chain	Q
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104
A	A	A	A	A	A	A	A	A	A	A	A	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	A	A	A	A	A	A	A	A	A	L	L	I	Y	Y	T	S	R	L	H	S	E	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	A	A	A	A	A	A	A	A	A	A	A	F	C	Q	Q	G	K	T	L	P	W	T	F	G	G	G	T	K	L

Antigen Details
Antigen chains	P,R
Antigen type	protein
Antigen name	protective antigen pa-63; fab
Antigen species	bacillus anthracis ; mus musculus
Antigen sequence	AAAAAAAAAAAAAAAAAAAAAAKASGYIFTNYNMHWVAAAAAAAAEWIGAIYPRTGDTSYNQKFKGKATLTADKSSSTAYAAAAAAAAAAAAAAACARDGFAYWAAAAAAAAA/TVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKE

CDR Sequences (chothia definition)
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGKTLPWT

Fv Details
Heavy chain
Light chain	N
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104
A	A	A	A	A	A	A	A	A	A	A	A	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	A	A	A	A	A	A	A	A	A	L	L	I	Y	Y	T	S	R	L	H	S	E	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	A	A	A	A	A	A	A	A	A	A	A	F	C	Q	Q	G	K	T	L	P	W	T	F	G	G	G	T	K	L

Antigen Details
Antigen chains	M,O
Antigen type	protein
Antigen name	protective antigen pa-63; fab
Antigen species	bacillus anthracis ; mus musculus
Antigen sequence	AAAAAAAAAAAAAAAAAAAAAAKASGYIFTNYNMHWVAAAAAAAAEWIGAIYPRTGDTSYNQKFKGKATLTADKSSSTAYAAAAAAAAAAAAAAACARDGFAYWAAAAAAAAA/TVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKE

CDR Sequences (chothia definition)
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGKTLPWT

Fv Details
Heavy chain
Light chain	B
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104
A	A	A	A	A	A	A	A	A	A	A	A	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	A	A	A	A	A	A	A	A	A	L	L	I	Y	Y	T	S	R	L	H	S	E	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	A	A	A	A	A	A	A	A	A	A	A	F	C	Q	Q	G	K	T	L	P	W	T	F	G	G	G	T	K	L

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	protective antigen pa-63
Antigen species	BACILLUS ANTHRACIS
Antigen sequence	TVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKE

CDR Sequences (chothia definition)
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGKTLPWT

Fv Details
Heavy chain
Light chain	K
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104
A	A	A	A	A	A	A	A	A	A	A	A	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	A	A	A	A	A	A	A	A	A	L	L	I	Y	Y	T	S	R	L	H	S	E	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	A	A	A	A	A	A	A	A	A	A	A	F	C	Q	Q	G	K	T	L	P	W	T	F	G	G	G	T	K	L

Antigen Details
Antigen chains	J,L
Antigen type	protein
Antigen name	protective antigen pa-63; fab
Antigen species	bacillus anthracis ; mus musculus
Antigen sequence	AAAAAAAAAAAAAAAAAAAAAAKASGYIFTNYNMHWVAAAAAAAAEWIGAIYPRTGDTSYNQKFKGKATLTADKSSSTAYAAAAAAAAAAAAAAACARDGFAYWAAAAAAAAA/TVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKE

CDR Sequences (chothia definition)
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGKTLPWT

Fv Details
Heavy chain
Light chain	H
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104
A	A	A	A	A	A	A	A	A	A	A	A	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	A	A	A	A	A	A	A	A	A	L	L	I	Y	Y	T	S	R	L	H	S	E	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	A	A	A	A	A	A	A	A	A	A	A	F	C	Q	Q	G	K	T	L	P	W	T	F	G	G	G	T	K	L

Antigen Details
Antigen chains	G,I
Antigen type	protein
Antigen name	protective antigen pa-63; fab
Antigen species	bacillus anthracis ; mus musculus
Antigen sequence	AAAAAAAAAAAAAAAAAAAAAAKASGYIFTNYNMHWVAAAAAAAAEWIGAIYPRTGDTSYNQKFKGKATLTADKSSSTAYAAAAAAAAAAAAAAACARDGFAYWAAAAAAAAA/TVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKE

CDR Sequences (chothia definition)
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGKTLPWT

Fv Details
Heavy chain
Light chain	E
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104
A	A	A	A	A	A	A	A	A	A	A	A	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	A	A	A	A	A	A	A	A	A	L	L	I	Y	Y	T	S	R	L	H	S	E	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	A	A	A	A	A	A	A	A	A	A	A	F	C	Q	Q	G	K	T	L	P	W	T	F	G	G	G	T	K	L

Antigen Details
Antigen chains	D,F
Antigen type	protein
Antigen name	protective antigen pa-63; fab
Antigen species	bacillus anthracis ; mus musculus
Antigen sequence	AAAAAAAAAAAAAAAAAAAAAAKASGYIFTNYNMHWVAAAAAAAAEWIGAIYPRTGDTSYNQKFKGKATLTADKSSSTAYAAAAAAAAAAAAAAACARDGFAYWAAAAAAAAA/TVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKE

CDR Sequences (chothia definition)
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGKTLPWT

Fv Details
Heavy chain
Light chain	T
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Light chain

9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104
A	A	A	A	A	A	A	A	A	A	A	A	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	A	A	A	A	A	A	A	A	A	L	L	I	Y	Y	T	S	R	L	H	S	E	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	A	A	A	A	A	A	A	A	A	A	A	F	C	Q	Q	G	K	T	L	P	W	T	F	G	G	G	T	K	L

Antigen Details
Antigen chains	S,U
Antigen type	protein
Antigen name	protective antigen pa-63; fab
Antigen species	bacillus anthracis ; mus musculus
Antigen sequence	AAAAAAAAAAAAAAAAAAAAAAKASGYIFTNYNMHWVAAAAAAAAEWIGAIYPRTGDTSYNQKFKGKATLTADKSSSTAYAAAAAAAAAAAAAAACARDGFAYWAAAAAAAAA/TVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKE

CDR Sequences (chothia definition)
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGKTLPWT

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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