Structure Viewer: 7t0l

>   Structure details

HLA-B*27:05 in complex with the Pan-HLA-Ia Monoclonal antibody W6/32

PDB7t0l
SpeciesMUS MUSCULUS
MethodX-RAY DIFFRACTION
Resolution3Å
Number of Fvs2
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   G/K
Fv Details
Heavy chainG
Light chainK
Heavy subgroupIGHV2
Light subgroupIGKV6
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
V Q L K Q S G P G L V Q P S Q S L S L T C T V S G F S L T S Y G V H W V R Q P P G K G L E W L G V I W S G G S T D Y N A A F I S R L S I R K D N S K S Q V F F K M N S L Q A D D T A I Y Y C A R T F T T S T S A W F A Y W G Q G T L V T V S A

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
S I V M T Q T P K F L L V S A G D R V T I T C K A S Q S V S N D V A W Y Q Q K P G Q S P K L L I Y Y A S N R Y T G V P D R F T G S G Y G T D F T F T I S T V Q A E D L A V Y F C Q Q D Y S S P P W T F G G G T K L E I R

Antigen Details
Antigen chainsE,D
Antigen typeprotein
Antigen namebeta-2-microglobulin; mhc class i antigen
Antigen speciesHOMO SAPIENS
Antigen sequenceIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM/GSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEYWDRETQISKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQNAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP

CDR Sequences (chothia definition)
CDRH1GFSLTSY
CDRH2WSGGS
CDRH3TFTTSTSAWFAY
CDRL1KASQSVSNDVA
CDRL2YASNRYT
CDRL3QQDYSSPPWT

Orientation Angles (from ABangle)
HL-58.4°
HC175.12°
HC2115.47°
LC1119.57°
LC282.39°
dc15.81Å
>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV2
Light subgroupIGKV6
SpeciesMUS MUSCULUS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
V Q L K Q S G P G L V Q P S Q S L S L T C T V S G F S L T S Y G V H W V R Q P P G K G L E W L G V I W S G G S T D Y N A A F I S R L S I R K D N S K S Q V F F K M N S L Q A D D T A I Y Y C A R T F T T S T S A W F A Y W G Q G T L V T V S A

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
S I V M T Q T P K F L L V S A G D R V T I T C K A S Q S V S N D V A W Y Q Q K P G Q S P K L L I Y Y A S N R Y T G V P D R F T G S G Y G T D F T F T I S T V Q A E D L A V Y F C Q Q D Y S S P P W T F G G G T K L E I R

Antigen Details
Antigen chainsB,A
Antigen typeprotein
Antigen namebeta-2-microglobulin; mhc class i antigen
Antigen speciesHOMO SAPIENS
Antigen sequenceIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM/GSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEYWDRETQISKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQNAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP

CDR Sequences (chothia definition)
CDRH1GFSLTSY
CDRH2WSGGS
CDRH3TFTTSTSAWFAY
CDRL1KASQSVSNDVA
CDRL2YASNRYT
CDRL3QQDYSSPPWT

Orientation Angles (from ABangle)
HL-57.97°
HC175.87°
HC2115.7°
LC1120.1°
LC283.33°
dc15.8Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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