Structure Viewer: 7ugo

> Structure details

Cryo-Em Structure of Bg24 inferred Germline Fabs with Mature Cdr3S and 10-1074 Fabs in complex with Hiv-1 Env Immunogen Bg505-Sosipv4.1-Gt1

PDB	7ugo
Species	HOMO SAPIENS
Method	ELECTRON MICROSCOPY
Resolution	4.1Å
Number of Fvs	6
In complex	True
Light chain type	Lambda,unknown
Has constant region	False

> Fv information

This PDB has 6 Fv(s).

Fv Details
Heavy chain	M
Light chain	P
Heavy subgroup	unknown
Light subgroup	unknown
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	V	T	C	S	V	S	G	D	S	M	N	N	Y	Y	W	T	W	I	R	Q	S	P	G	K	G	L	E	W	I	G	Y	I	S	D	R	E	S	A	T	Y	N	P	S	L	N	S	R	V	V	I	S	R	D	T	S	K	N	Q	L	S	L	K	L	N	S	V	T	P	A	D	T	A	V	Y	Y	C	A	T	A	R	R	G	Q	R	I	Y	G	V	V	S	F	G	E	F	F	Y	Y	Y	S	M	D	V	W	G	K	G	T	T	V	T	V	S	S

Light chain

11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	68A	68B	68C	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
L	S	V	A	L	G	E	T	A	R	I	S	C	G	R	Q	A	L	G	S	R	A	V	Q	W	Y	Q	H	R	P	G	Q	A	P	I	L	L	I	Y	N	N	Q	D	R	P	S	G	I	P	E	R	F	S	G	T	P	D	I	N	F	G	T	R	A	T	L	T	I	S	G	V	E	A	G	D	E	A	D	Y	Y	C	H	M	W	D	S	R	S	G	F	S	W	S	F	G	G	A	T	R	L	T	V	L

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	ENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINENQNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSEDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	GDSMNNY
CDRH2	SDRES
CDRH3	ARRGQRIYGVVSFGEFFYYYSMDV
CDRL1	GRQALGSRAVQ
CDRL2	NNQDRPS
CDRL3	HMWDSRSGFSWS

Orientation Angles (from ABangle)
HL	-53.6°
HC1	73.86°
HC2	121.96°
LC1	127.4°
LC2	89.73°
dc	18.2Å

Fv Details
Heavy chain	N
Light chain	Q
Heavy subgroup	unknown
Light subgroup	unknown
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	V	T	C	S	V	S	G	D	S	M	N	N	Y	Y	W	T	W	I	R	Q	S	P	G	K	G	L	E	W	I	G	Y	I	S	D	R	E	S	A	T	Y	N	P	S	L	N	S	R	V	V	I	S	R	D	T	S	K	N	Q	L	S	L	K	L	N	S	V	T	P	A	D	T	A	V	Y	Y	C	A	T	A	R	R	G	Q	R	I	Y	G	V	V	S	F	G	E	F	F	Y	Y	Y	S	M	D	V	W	G	K	G	T	T	V	T	V	S	S

Light chain

11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	68A	68B	68C	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
L	S	V	A	L	G	E	T	A	R	I	S	C	G	R	Q	A	L	G	S	R	A	V	Q	W	Y	Q	H	R	P	G	Q	A	P	I	L	L	I	Y	N	N	Q	D	R	P	S	G	I	P	E	R	F	S	G	T	P	D	I	N	F	G	T	R	A	T	L	T	I	S	G	V	E	A	G	D	E	A	D	Y	Y	C	H	M	W	D	S	R	S	G	F	S	W	S	F	G	G	A	T	R	L	T	V	L

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	ENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINENQNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSEDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	GDSMNNY
CDRH2	SDRES
CDRH3	ARRGQRIYGVVSFGEFFYYYSMDV
CDRL1	GRQALGSRAVQ
CDRL2	NNQDRPS
CDRL3	HMWDSRSGFSWS

Orientation Angles (from ABangle)
HL	-53.77°
HC1	73.64°
HC2	121.69°
LC1	127.47°
LC2	89.69°
dc	18.17Å

Fv Details
Heavy chain	O
Light chain	R
Heavy subgroup	unknown
Light subgroup	unknown
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	100N	100O	100P	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	V	T	C	S	V	S	G	D	S	M	N	N	Y	Y	W	T	W	I	R	Q	S	P	G	K	G	L	E	W	I	G	Y	I	S	D	R	E	S	A	T	Y	N	P	S	L	N	S	R	V	V	I	S	R	D	T	S	K	N	Q	L	S	L	K	L	N	S	V	T	P	A	D	T	A	V	Y	Y	C	A	T	A	R	R	G	Q	R	I	Y	G	V	V	S	F	G	E	F	F	Y	Y	Y	S	M	D	V	W	G	K	G	T	T	V	T	V	S	S

Light chain

11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	68A	68B	68C	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	95C	96	97	98	99	100	101	102	103	104	105	106	107
L	S	V	A	L	G	E	T	A	R	I	S	C	G	R	Q	A	L	G	S	R	A	V	Q	W	Y	Q	H	R	P	G	Q	A	P	I	L	L	I	Y	N	N	Q	D	R	P	S	G	I	P	E	R	F	S	G	T	P	D	I	N	F	G	T	R	A	T	L	T	I	S	G	V	E	A	G	D	E	A	D	Y	Y	C	H	M	W	D	S	R	S	G	F	S	W	S	F	G	G	A	T	R	L	T	V	L

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	ENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINENQNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSEDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	GDSMNNY
CDRH2	SDRES
CDRH3	ARRGQRIYGVVSFGEFFYYYSMDV
CDRL1	GRQALGSRAVQ
CDRL2	NNQDRPS
CDRL3	HMWDSRSGFSWS

Orientation Angles (from ABangle)
HL	-53.73°
HC1	73.8°
HC2	121.95°
LC1	127.42°
LC2	89.64°
dc	18.17Å

Fv Details
Heavy chain	G
Light chain	J
Heavy subgroup	IGHV1
Light subgroup	IGLV2
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	K	P	G	A	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	G	Y	Y	M	H	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	W	I	N	P	N	S	G	G	T	N	Y	A	Q	K	F	Q	G	R	V	T	M	T	R	D	T	S	I	S	T	A	Y	M	E	L	S	R	L	R	S	D	D	T	A	V	Y	Y	C	A	T	Q	V	K	L	D	S	S	A	G	Y	P	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	A	L	T	Q	P	R	S	V	S	G	S	P	G	Q	S	V	T	I	S	C	T	G	T	S	S	D	V	G	G	Y	N	Y	V	S	W	Y	Q	Q	H	P	G	K	A	P	K	L	M	I	Y	D	V	S	K	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	N	T	A	S	L	T	I	S	G	L	Q	A	E	D	E	A	D	Y	Y	C	S	A	F	E	Y	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	ENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINENQNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSEDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	GYTFTGY
CDRH2	NPNSGG
CDRH3	QVKLDSSAGYPFDI
CDRL1	TGTSSDVGGYNYVS
CDRL2	DVSKRPS
CDRL3	SAFEY

Orientation Angles (from ABangle)
HL	-55.85°
HC1	78.7°
HC2	113.75°
LC1	121.87°
LC2	86.63°
dc	16.86Å

Fv Details
Heavy chain	H
Light chain	K
Heavy subgroup	IGHV1
Light subgroup	IGLV2
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	K	P	G	A	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	G	Y	Y	M	H	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	W	I	N	P	N	S	G	G	T	N	Y	A	Q	K	F	Q	G	R	V	T	M	T	R	D	T	S	I	S	T	A	Y	M	E	L	S	R	L	R	S	D	D	T	A	V	Y	Y	C	A	T	Q	V	K	L	D	S	S	A	G	Y	P	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	A	L	T	Q	P	R	S	V	S	G	S	P	G	Q	S	V	T	I	S	C	T	G	T	S	S	D	V	G	G	Y	N	Y	V	S	W	Y	Q	Q	H	P	G	K	A	P	K	L	M	I	Y	D	V	S	K	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	N	T	A	S	L	T	I	S	G	L	Q	A	E	D	E	A	D	Y	Y	C	S	A	F	E	Y	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	ENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINENQNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSEDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	GYTFTGY
CDRH2	NPNSGG
CDRH3	QVKLDSSAGYPFDI
CDRL1	TGTSSDVGGYNYVS
CDRL2	DVSKRPS
CDRL3	SAFEY

Orientation Angles (from ABangle)
HL	-55.76°
HC1	78.87°
HC2	113.59°
LC1	121.51°
LC2	86.98°
dc	16.83Å

Fv Details
Heavy chain	I
Light chain	L
Heavy subgroup	IGHV1
Light subgroup	IGLV2
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	K	P	G	A	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	G	Y	Y	M	H	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	W	I	N	P	N	S	G	G	T	N	Y	A	Q	K	F	Q	G	R	V	T	M	T	R	D	T	S	I	S	T	A	Y	M	E	L	S	R	L	R	S	D	D	T	A	V	Y	Y	C	A	T	Q	V	K	L	D	S	S	A	G	Y	P	F	D	I	W	G	Q	G	T	M	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	A	L	T	Q	P	R	S	V	S	G	S	P	G	Q	S	V	T	I	S	C	T	G	T	S	S	D	V	G	G	Y	N	Y	V	S	W	Y	Q	Q	H	P	G	K	A	P	K	L	M	I	Y	D	V	S	K	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	N	T	A	S	L	T	I	S	G	L	Q	A	E	D	E	A	D	Y	Y	C	S	A	F	E	Y	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	envelope glycoprotein gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	ENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINENQNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSEDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVV

CDR Sequences (chothia definition)
CDRH1	GYTFTGY
CDRH2	NPNSGG
CDRH3	QVKLDSSAGYPFDI
CDRL1	TGTSSDVGGYNYVS
CDRL2	DVSKRPS
CDRL3	SAFEY

Orientation Angles (from ABangle)
HL	-55.9°
HC1	79.22°
HC2	113.84°
LC1	121.79°
LC2	86.92°
dc	16.88Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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