Structure Viewer: 7urv

>   Structure details

Fmc63 Scfv in complex with Soluble CD19

PDB7urv
SpeciesMUS MUSCULUS
MethodELECTRON MICROSCOPY
Resolution
Number of Fvs1
In complexTrue
Light chain typeunknown
Has constant regionFalse
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>   Fv information

This PDB has 1 Fv(s).

>   D/D
Fv Details
Heavy chainD
Light chainD
Heavy subgroupunknown
Light subgroupunknown
SpeciesMUS MUSCULUS
In complex?True
scFv?True
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L Q E S G P G L V A P S Q S L S V T C T V S G V S L P D Y G V S W I R Q P P R K G L E W L G V I W G S E T T Y Y N S A L K S R L T I I K D N S K S Q V F L K M N S L Q T D D T A I Y Y C A K H Y Y Y G G S Y A M D Y W G Q G T S V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106
D I Q M T Q T T S S L S A S L G D R V T I S C R A S Q D I S K Y L N W Y Q Q K P D G T V K L L I Y H T S R L H S G V P S R F S G S G S G T D Y S L T I S N L E Q E D I A T Y F C Q Q G N T L P Y T F G G G T K L E I

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen nameb-lymphocyte antigen cd19
Antigen speciesHOMO SAPIENS
Antigen sequenceEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHVSPLAIWLFISNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITAR

CDR Sequences (chothia definition)
CDRH1GVSLPDY
CDRH2WGSET
CDRH3HYYYGGSYAMDY
CDRL1RASQDISKYLN
CDRL2HTSRLHS
CDRL3QQGNTLPYT

Orientation Angles (from ABangle)
HL-66.69°
HC169.82°
HC2114.57°
LC1119.91°
LC278.82°
dc15.53Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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