Structure Viewer: 7yud

>   Structure details

Fty720P-Bound Human Spns2

PDB7yud
SpeciesSYNTHETIC CONSTRUCT (CODE 12); LAMA GLAMA
MethodELECTRON MICROSCOPY
Resolution2.98Å
Number of Fvs3
In complexTrue
Light chain typeKappa,NA
Has constant regionTrue
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>   Fv information

This PDB has 3 Fv(s).

>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesSYNTHETIC CONSTRUCT (CODE 12)
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V Q P G G S L R L S C A A S G F N F S Y Y S I H W V R Q A P G K G L E W V A Y I S S S S S Y T S Y A D S V K G R F T I S A D T S K N T A Y L Q M N S L R A E D T A V Y Y C A R G Y Q Y W Q Y H A S W Y W N G G L D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C R A S Q S V S S A V A W Y Q Q K P G K A P K L L I Y S A S S L Y S G V P S R F S G S R S G T D F T L T I S S L Q P E D F A T Y Y C Q Q S S S S L I T F G Q G T K V E I K

Antigen Details
Antigen chainsR
Antigen typeprotein
Antigen namesphingosine-1-phosphate transporter spns2
Antigen speciesHOMO SAPIENS
Antigen sequenceMMCLECASAAAGGAEEEEADAERRRRRRGAQRGAGGSGCCGARGAGGAGVSAAGDEVQTLSGSVRRAPTGPPGTPGTPGCAATAKGPGAQQPKPASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGHADQLGDQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLATALFFVSDRARAEQQVNQLAMPPASVKV

CDR Sequences (chothia definition)
CDRH1GFNFSYY
CDRH2SSSSSY
CDRH3GYQYWQYHASWYWNGGLDY
CDRL1RASQSVSSAVA
CDRL2SASSLYS
CDRL3QQSSSSLIT

Orientation Angles (from ABangle)
HL-55.72°
HC172.77°
HC2121.19°
LC1121.34°
LC285.43°
dc17.15Å
>   N/-
Fv Details
Heavy chainN
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 101 102 103 104 105 106 107 108 109 110 111 112 113
Q R Q L V E S G G G L V Q P G G S L R L S C A A P G S R R F D Y Y T L G W F R Q A P G K E R E G V S C I S T V G G I T N Y A D S V K G R F I I S R D N A K S T V Y L Q M N S L E P E D T A V Y Y C A A G R E M C A P M M L G D Y Y D M D Y W G K G T P V T V S S

Antigen Details
Antigen chainsR
Antigen typeprotein
Antigen namesphingosine-1-phosphate transporter spns2
Antigen speciesHOMO SAPIENS
Antigen sequenceMMCLECASAAAGGAEEEEADAERRRRRRGAQRGAGGSGCCGARGAGGAGVSAAGDEVQTLSGSVRRAPTGPPGTPGTPGCAATAKGPGAQQPKPASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGHADQLGDQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLATALFFVSDRARAEQQVNQLAMPPASVKV

CDR Sequences (chothia definition)
CDRH1GSRRFDYY
CDRH2STVGGI
CDRH3GREMCAPMMLGDYYDMDY

>   K/-
Fv Details
Heavy chainK
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?False
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G L V Q P G G S L R L S C A A S G R T I S R Y A M S W F R Q A P G K E R E F V A V A R R S G D G A F Y A D S V Q G R F T V S R D D A K N T V Y L Q M N S L K P E D T A V Y Y C A I D S D T F Y S G S Y D Y W G Q G T Q V T V S S


CDR Sequences (chothia definition)
CDRH1GRTISRY
CDRH2RRSGDG
CDRH3DSDTFYSGSYDY

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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