Structure Viewer: 8cpe

> Structure details

Cryoem Structure of al55 amyloid Fibrils Extracted From the Kidney of an al amyloidosis Patient.

PDB	8cpe
Species	HOMO SAPIENS
Method	ELECTRON MICROSCOPY
Resolution	4.0Å
Number of Fvs	5
In complex	False
Light chain type	Lambda
Has constant region	True

> Fv information

This PDB has 5 Fv(s).

Fv Details
Heavy chain
Light chain	C
Heavy subgroup	NA
Light subgroup	IGLV6
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	68A	68B	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
N	F	M	L	T	Q	P	H	S	V	S	E	S	P	G	K	T	L	T	I	S	C	T	G	S	S	A	S	I	A	S	H	Y	V	Q	W	Y	Q	Q	R	P	G	G	A	P	T	T	L	I	Y	E	N	D	Q	R	P	S	E	V	P	D	R	F	S	G	S	I	D	S	S	S	N	S	A	S	L	T	I	S	G	L	K	T	E	D	E	A	D	Y	Y	C	Q	S	Y	D	G	N	N	H	W	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRL1	TGSSASIASHYVQ
CDRL2	ENDQRPS
CDRL3	QSYDGNNHWV

Fv Details
Heavy chain
Light chain	A
Heavy subgroup	NA
Light subgroup	IGLV6
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	68A	68B	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
N	F	M	L	T	Q	P	H	S	V	S	E	S	P	G	K	T	L	T	I	S	C	T	G	S	S	A	S	I	A	S	H	Y	V	Q	W	Y	Q	Q	R	P	G	G	A	P	T	T	L	I	Y	E	N	D	Q	R	P	S	E	V	P	D	R	F	S	G	S	I	D	S	S	S	N	S	A	S	L	T	I	S	G	L	K	T	E	D	E	A	D	Y	Y	C	Q	S	Y	D	G	N	N	H	W	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRL1	TGSSASIASHYVQ
CDRL2	ENDQRPS
CDRL3	QSYDGNNHWV

Fv Details
Heavy chain
Light chain	B
Heavy subgroup	NA
Light subgroup	IGLV6
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	68A	68B	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
N	F	M	L	T	Q	P	H	S	V	S	E	S	P	G	K	T	L	T	I	S	C	T	G	S	S	A	S	I	A	S	H	Y	V	Q	W	Y	Q	Q	R	P	G	G	A	P	T	T	L	I	Y	E	N	D	Q	R	P	S	E	V	P	D	R	F	S	G	S	I	D	S	S	S	N	S	A	S	L	T	I	S	G	L	K	T	E	D	E	A	D	Y	Y	C	Q	S	Y	D	G	N	N	H	W	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRL1	TGSSASIASHYVQ
CDRL2	ENDQRPS
CDRL3	QSYDGNNHWV

Fv Details
Heavy chain
Light chain	D
Heavy subgroup	NA
Light subgroup	IGLV6
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	68A	68B	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
N	F	M	L	T	Q	P	H	S	V	S	E	S	P	G	K	T	L	T	I	S	C	T	G	S	S	A	S	I	A	S	H	Y	V	Q	W	Y	Q	Q	R	P	G	G	A	P	T	T	L	I	Y	E	N	D	Q	R	P	S	E	V	P	D	R	F	S	G	S	I	D	S	S	S	N	S	A	S	L	T	I	S	G	L	K	T	E	D	E	A	D	Y	Y	C	Q	S	Y	D	G	N	N	H	W	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRL1	TGSSASIASHYVQ
CDRL2	ENDQRPS
CDRL3	QSYDGNNHWV

Fv Details
Heavy chain
Light chain	E
Heavy subgroup	NA
Light subgroup	IGLV6
Species	HOMO SAPIENS
In complex?	False
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	68A	68B	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
N	F	M	L	T	Q	P	H	S	V	S	E	S	P	G	K	T	L	T	I	S	C	T	G	S	S	A	S	I	A	S	H	Y	V	Q	W	Y	Q	Q	R	P	G	G	A	P	T	T	L	I	Y	E	N	D	Q	R	P	S	E	V	P	D	R	F	S	G	S	I	D	S	S	S	N	S	A	S	L	T	I	S	G	L	K	T	E	D	E	A	D	Y	Y	C	Q	S	Y	D	G	N	N	H	W	V	F	G	G	G	T	K	L	T	V	L

CDR Sequences (chothia definition)
CDRL1	TGSSASIASHYVQ
CDRL2	ENDQRPS
CDRL3	QSYDGNNHWV

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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