Structure Viewer: 8cz8

>   Structure details

Novel anti-Mesothelin antibodies Enable Crystallography of the intact Mesothelin Ectodo- Main and Engineering of Potent, T Cell-Engaging Bispecific therapeutics

PDB8cz8
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution2.6Å
Number of Fvs4
In complexTrue
Light chain typeunknown
Has constant regionFalse
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>   Fv information

This PDB has 4 Fv(s).

>   C/C
Fv Details
Heavy chainC
Light chainC
Heavy subgroupunknown
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?True
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V E L V Q S G A E V K K P G E S L K I S C K G S G Y S F T S Y W I G W V R Q A P G K G L E W M G I I D P G D S R T R Y S P S F Q G Q V T I S A D K S I S T A Y L Q W S S L K A S D T A M Y Y C A R G Q L Y G G T Y M D G W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
D I A L T Q P A S V S G S P G Q S I T I S C T G T S S D I G G Y N S V S W Y Q Q H P G K A P K L M I Y G V N N R P S G V S N R F S G S K S G N T A S L T I S G L Q A E D E A D Y Y C S S Y D I E S A T P V F G G G T K L T V L

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namemesothelin, cleaved form
Antigen speciesHOMO SAPIENS
Antigen sequenceGSDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGI

CDR Sequences (chothia definition)
CDRH1GYSFTSY
CDRH2DPGDSR
CDRH3GQLYGGTYMDG
CDRL1TGTSSDIGGYNSVS
CDRL2GVNNRPS
CDRL3SSYDIESATPV

Orientation Angles (from ABangle)
HL-53.18°
HC168.72°
HC2116.57°
LC1120.83°
LC284.72°
dc16.48Å
>   D/D
Fv Details
Heavy chainD
Light chainD
Heavy subgroupunknown
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?True
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L L E S G G G L V Q P G G S L R L S C A A S G L T F R S Y A M T W V R Q A P G K G L E W V S G I S V S G G I T Y Y A D S V K G R F T I S R D N S K N T L Y L Q M N S L R A E D T A V Y Y C A K R G A A V G S F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C R S S Q G I G S W L A W Y Q Q K P E K A P Q S L I Y A A S S L Q S G V P S R F S G S G S G T D F T L T I S N L Q P E D F A T Y Y C Q Q Y N S Y P L T F G G G T K V E I K

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namemesothelin, cleaved form
Antigen speciesHOMO SAPIENS
Antigen sequenceGSDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGI

CDR Sequences (chothia definition)
CDRH1GLTFRSY
CDRH2SVSGGI
CDRH3RGAAVGSFDY
CDRL1RSSQGIGSWLA
CDRL2AASSLQS
CDRL3QQYNSYPLT

Orientation Angles (from ABangle)
HL-64.69°
HC169.95°
HC2117.83°
LC1121.06°
LC282.69°
dc16.03Å
>   A/A
Fv Details
Heavy chainA
Light chainA
Heavy subgroupunknown
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?True
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V E L V Q S G A E V K K P G E S L K I S C K G S G Y S F T S Y W I G W V R Q A P G K G L E W M G I I D P G D S R T R Y S P S F Q G Q V T I S A D K S I S T A Y L Q W S S L K A S D T A M Y Y C A R G Q L Y G G T Y M D G W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
D I A L T Q P A S V S G S P G Q S I T I S C T G T S S D I G G Y N S V S W Y Q Q H P G K A P K L M I Y G V N N R P S G V S N R F S G S K S G N T A S L T I S G L Q A E D E A D Y Y C S S Y D I E S A T P V F G G G T K L T V L

Antigen Details
Antigen chainsM
Antigen typeprotein
Antigen namemesothelin, cleaved form
Antigen speciesHOMO SAPIENS
Antigen sequenceGSDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGI

CDR Sequences (chothia definition)
CDRH1GYSFTSY
CDRH2DPGDSR
CDRH3GQLYGGTYMDG
CDRL1TGTSSDIGGYNSVS
CDRL2GVNNRPS
CDRL3SSYDIESATPV

Orientation Angles (from ABangle)
HL-53.46°
HC168.7°
HC2116.51°
LC1121.56°
LC284.9°
dc16.48Å
>   B/B
Fv Details
Heavy chainB
Light chainB
Heavy subgroupunknown
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?True
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L L E S G G G L V Q P G G S L R L S C A A S G L T F R S Y A M T W V R Q A P G K G L E W V S G I S V S G G I T Y Y A D S V K G R F T I S R D N S K N T L Y L Q M N S L R A E D T A V Y Y C A K R G A A V G S F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C R S S Q G I G S W L A W Y Q Q K P E K A P Q S L I Y A A S S L Q S G V P S R F S G S G S G T D F T L T I S N L Q P E D F A T Y Y C Q Q Y N S Y P L T F G G G T K V E I K

Antigen Details
Antigen chainsM
Antigen typeprotein
Antigen namemesothelin, cleaved form
Antigen speciesHOMO SAPIENS
Antigen sequenceGSDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGI

CDR Sequences (chothia definition)
CDRH1GLTFRSY
CDRH2SVSGGI
CDRH3RGAAVGSFDY
CDRL1RSSQGIGSWLA
CDRL2AASSLQS
CDRL3QQYNSYPLT

Orientation Angles (from ABangle)
HL-64.21°
HC170.06°
HC2118.12°
LC1121.44°
LC283.07°
dc16.02Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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