Structure Viewer: 8ezl

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Pfs25 in complex with Transmission-Reducing antibody as01-50

PDB8ezl
SpeciesPLASMODIUM FALCIPARUM NF54
MethodX-RAY DIFFRACTION
Resolution2.3Å
Number of Fvs1
In complexTrue
Light chain typeunknown
Has constant regionFalse
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>   Fv information

This PDB has 1 Fv(s).

>   H/H
Fv Details
Heavy chainH
Light chainH
Heavy subgroupunknown
Light subgroupunknown
SpeciesPLASMODIUM FALCIPARUM NF54
In complex?True
scFv?True
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 101 102 103 104 105 106 107 108 109 110 111 112 113
Q I T L K E S G P T L V K P T Q T L T L T C T F S G S S L S T S G V G V G W I R Q P P G K A L E W L A L I Y W N D D K R Y S P S L K R R L T I T K D T S K N Q V V L T M T N M D P V D T A T Y Y C V H R G S A P Y Y Y D S S G Y Y S T F Y Y F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 52B 52C 52D 52E 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 95D 95E 96 97 98 99 100 101 102 103 104 105 106 107
Q P V L T Q P P S A S A S L G A S L S L T C T L S S G Y N N Y K V D W Y Q Q R P G K G P R F V M R V G T G G I V G S K G D G I P D R F S V L G S G L N R N L T I K N I Q E D D E S D Y H C G A D H G S G S N L D Y V V F G G G T K L T V L

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen name25 kda ookinete surface antigen
Antigen speciesPLASMODIUM FALCIPARUM NF54
Antigen sequenceTGKVTVDTVCKRGFLIQMSGHLECKCENDLVLVNEETCEEKVLKCDEKTVNKPCGDFSKCIKIDGNPVSYACKCNLGYDMVNNVCIPNECKQVTCGNGKCILDTSNPVKTGVCSCNIGKVPNVQDQNKCSKDGETKCSLKCLKEQETCKAVDGIYKCDCKDGFIIDQESSICTGTKHHHHHH

CDR Sequences (chothia definition)
CDRH1GSSLSTSGV
CDRH2YWNDD
CDRH3RGSAPYYYDSSGYYSTFYYFDY
CDRL1TLSSGYNNYKVD
CDRL2VGTGGIVGSKGD
CDRL3GADHGSGSNLDYVV

Orientation Angles (from ABangle)
HL-59.83°
HC175.4°
HC2118.27°
LC1124.35°
LC284.25°
dc15.49Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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