Structure Viewer: 8f6l

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anti-Btla Monoclonal antibody H25F7 in complex with Btla

PDB8f6l
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution1.85Å
Number of Fvs1
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 1 Fv(s).

>   A/B
Fv Details
Heavy chainA
Light chainB
Heavy subgroupIGHV1
Light subgroupIGKV4
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V Q S G A E V K K P G A S V K V S C K A S G F S L W T Y A M N W V R Q A P G Q G L E W M G I I S D D G T T Y Y A T W A K G R V T M T R D T S T S T V Y M E L S S L R S E D T A V Y Y C A R D A G A G G V Q D Y L T L W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
D I V M T Q S P D S L A V S L G E R A T I N C Q A S R N I Y N F L A W Y Q Q K P G Q P P K L L I Y S A S T L A S G V P D R F S G S G S G T D F T L T I S S L Q A E D V A V Y Y C Q Q G S S N S N I D N P F G G G T K V E I K

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen nameb- and t-lymphocyte attenuator
Antigen speciesHOMO SAPIENS
Antigen sequenceKESCDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANFQSNLIESHSTTLYVTDVKSASERPSKDEMASEFHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GFSLWTY
CDRH2SDDGT
CDRH3DAGAGGVQDYLTL
CDRL1QASRNIYNFLA
CDRL2SASTLAS
CDRL3QQGSSNSNIDNP

Orientation Angles (from ABangle)
HL-53.6°
HC170.91°
HC2118.98°
LC1122.77°
LC282.36°
dc16.39Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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