Structure Viewer: 8hrd

> Structure details

Crystal Structure of the Receptor Binding Domain of Sars-Cov-2 Delta Variant in complex with Imcas74 Fab and W14 Fab

PDB	8hrd
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.86Å
Number of Fvs	8
In complex	True
Light chain type	Kappa,Lambda
Has constant region	True

> Fv information

This PDB has 8 Fv(s).

Fv Details
Heavy chain	O
Light chain	P
Heavy subgroup	IGHV5
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	Q	L	K	K	P	G	E	S	L	K	I	S	C	K	G	S	G	Y	N	F	S	R	Y	W	I	A	W	V	R	H	M	P	G	K	G	L	E	V	M	G	I	I	Y	P	D	D	S	D	T	R	Y	S	P	S	V	R	G	Q	V	T	I	S	A	D	K	S	T	S	I	V	Y	L	Q	W	S	S	L	K	A	S	D	T	G	I	Y	Y	C	A	R	F	G	A	G	M	T	G	M	P	R	Y	F	D	T	T	R	W	F	D	P	W	G	Q	G	T	Q	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	V	L	T	Q	P	P	S	V	S	G	A	P	G	Q	R	V	T	I	S	C	L	G	G	S	S	N	I	G	A	G	Y	D	V	H	W	Y	Q	H	L	P	G	A	A	P	K	L	L	I	S	G	N	S	N	R	P	S	G	V	P	A	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	T	G	L	Q	A	E	D	E	A	D	Y	Y	C	Q	S	Y	D	N	D	L	S	Q	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF

CDR Sequences (chothia definition)
CDRH1	GYNFSRY
CDRH2	YPDDSD
CDRH3	FGAGMTGMPRYFDTTRWFDP
CDRL1	LGGSSNIGAGYDVH
CDRL2	GNSNRPS
CDRL3	QSYDNDLSQV

Orientation Angles (from ABangle)
HL	-53.31°
HC1	71.48°
HC2	112.2°
LC1	123.32°
LC2	82.13°
dc	16.24Å

Fv Details
Heavy chain	D
Light chain	F
Heavy subgroup	IGHV4
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	T	C	T	V	S	S	G	S	I	S	G	T	S	Y	Y	W	D	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	T	I	Y	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	V	T	I	S	V	D	T	S	K	N	Q	F	S	L	K	L	S	P	V	T	A	A	G	T	A	V	Y	Y	C	A	R	R	T	F	Y	Y	D	R	S	G	Q	K	V	V	E	P	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	S	T	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	I	S	S	W	L	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	E	A	S	S	L	E	N	G	V	P	S	R	F	S	G	S	G	S	G	T	E	F	T	L	T	I	S	S	L	Q	P	D	D	F	A	T	Y	Y	C	Q	Q	Y	N	S	Y	S	L	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF

CDR Sequences (chothia definition)
CDRH1	SGSISGTSY
CDRH2	YYSGS
CDRH3	RTFYYDRSGQKVVEPFDY
CDRL1	RASQSISSWLA
CDRL2	EASSLEN
CDRL3	QQYNSYSLT

Orientation Angles (from ABangle)
HL	-60.5°
HC1	75.7°
HC2	119.4°
LC1	119.89°
LC2	81.14°
dc	16.19Å

Fv Details
Heavy chain	C
Light chain	E
Heavy subgroup	IGHV5
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	Q	L	K	K	P	G	E	S	L	K	I	S	C	K	G	S	G	Y	N	F	S	R	Y	W	I	A	W	V	R	H	M	P	G	K	G	L	E	V	M	G	I	I	Y	P	D	D	S	D	T	R	Y	S	P	S	V	R	G	Q	V	T	I	S	A	D	K	S	T	S	I	V	Y	L	Q	W	S	S	L	K	A	S	D	T	G	I	Y	Y	C	A	R	F	G	A	G	M	T	G	M	P	R	Y	F	D	T	T	R	W	F	D	P	W	G	Q	G	T	Q	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	V	L	T	Q	P	P	S	V	S	G	A	P	G	Q	R	V	T	I	S	C	L	G	G	S	S	N	I	G	A	G	Y	D	V	H	W	Y	Q	H	L	P	G	A	A	P	K	L	L	I	S	G	N	S	N	R	P	S	G	V	P	A	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	T	G	L	Q	A	E	D	E	A	D	Y	Y	C	Q	S	Y	D	N	D	L	S	Q	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF

CDR Sequences (chothia definition)
CDRH1	GYNFSRY
CDRH2	YPDDSD
CDRH3	FGAGMTGMPRYFDTTRWFDP
CDRL1	LGGSSNIGAGYDVH
CDRL2	GNSNRPS
CDRL3	QSYDNDLSQV

Orientation Angles (from ABangle)
HL	-53.65°
HC1	70.79°
HC2	111.97°
LC1	123.78°
LC2	81.47°
dc	16.27Å

Fv Details
Heavy chain	G
Light chain	H
Heavy subgroup	IGHV4
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	T	C	T	V	S	S	G	S	I	S	G	T	S	Y	Y	W	D	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	T	I	Y	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	V	T	I	S	V	D	T	S	K	N	Q	F	S	L	K	L	S	P	V	T	A	A	G	T	A	V	Y	Y	C	A	R	R	T	F	Y	Y	D	R	S	G	Q	K	V	V	E	P	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	S	T	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	I	S	S	W	L	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	E	A	S	S	L	E	N	G	V	P	S	R	F	S	G	S	G	S	G	T	E	F	T	L	T	I	S	S	L	Q	P	D	D	F	A	T	Y	Y	C	Q	Q	Y	N	S	Y	S	L	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF

CDR Sequences (chothia definition)
CDRH1	SGSISGTSY
CDRH2	YYSGS
CDRH3	RTFYYDRSGQKVVEPFDY
CDRL1	RASQSISSWLA
CDRL2	EASSLEN
CDRL3	QQYNSYSLT

Orientation Angles (from ABangle)
HL	-63.43°
HC1	76.18°
HC2	118.72°
LC1	119.29°
LC2	81.87°
dc	16.29Å

Fv Details
Heavy chain	L
Light chain	M
Heavy subgroup	IGHV5
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	Q	L	K	K	P	G	E	S	L	K	I	S	C	K	G	S	G	Y	N	F	S	R	Y	W	I	A	W	V	R	H	M	P	G	K	G	L	E	V	M	G	I	I	Y	P	D	D	S	D	T	R	Y	S	P	S	V	R	G	Q	V	T	I	S	A	D	K	S	T	S	I	V	Y	L	Q	W	S	S	L	K	A	S	D	T	G	I	Y	Y	C	A	R	F	G	A	G	M	T	G	M	P	R	Y	F	D	T	T	R	W	F	D	P	W	G	Q	G	T	Q	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	V	L	T	Q	P	P	S	V	S	G	A	P	G	Q	R	V	T	I	S	C	L	G	G	S	S	N	I	G	A	G	Y	D	V	H	W	Y	Q	H	L	P	G	A	A	P	K	L	L	I	S	G	N	S	N	R	P	S	G	V	P	A	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	T	G	L	Q	A	E	D	E	A	D	Y	Y	C	Q	S	Y	D	N	D	L	S	Q	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	K
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF

CDR Sequences (chothia definition)
CDRH1	GYNFSRY
CDRH2	YPDDSD
CDRH3	FGAGMTGMPRYFDTTRWFDP
CDRL1	LGGSSNIGAGYDVH
CDRL2	GNSNRPS
CDRL3	QSYDNDLSQV

Orientation Angles (from ABangle)
HL	-53.1°
HC1	71.35°
HC2	112.46°
LC1	122.59°
LC2	83.22°
dc	16.31Å

Fv Details
Heavy chain	N
Light chain	Q
Heavy subgroup	IGHV4
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	T	C	T	V	S	S	G	S	I	S	G	T	S	Y	Y	W	D	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	T	I	Y	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	V	T	I	S	V	D	T	S	K	N	Q	F	S	L	K	L	S	P	V	T	A	A	G	T	A	V	Y	Y	C	A	R	R	T	F	Y	Y	D	R	S	G	Q	K	V	V	E	P	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	S	T	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	I	S	S	W	L	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	E	A	S	S	L	E	N	G	V	P	S	R	F	S	G	S	G	S	G	T	E	F	T	L	T	I	S	S	L	Q	P	D	D	F	A	T	Y	Y	C	Q	Q	Y	N	S	Y	S	L	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	K
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF

CDR Sequences (chothia definition)
CDRH1	SGSISGTSY
CDRH2	YYSGS
CDRH3	RTFYYDRSGQKVVEPFDY
CDRL1	RASQSISSWLA
CDRL2	EASSLEN
CDRL3	QQYNSYSLT

Orientation Angles (from ABangle)
HL	-61.75°
HC1	74.97°
HC2	119.55°
LC1	120.85°
LC2	81.22°
dc	16.39Å

Fv Details
Heavy chain	W
Light chain	X
Heavy subgroup	IGHV5
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	Q	L	K	K	P	G	E	S	L	K	I	S	C	K	G	S	G	Y	N	F	S	R	Y	W	I	A	W	V	R	H	M	P	G	K	G	L	E	V	M	G	I	I	Y	P	D	D	S	D	T	R	Y	S	P	S	V	R	G	Q	V	T	I	S	A	D	K	S	T	S	I	V	Y	L	Q	W	S	S	L	K	A	S	D	T	G	I	Y	Y	C	A	R	F	G	A	G	M	T	G	M	P	R	Y	F	D	T	T	R	W	F	D	P	W	G	Q	G	T	Q	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	V	L	T	Q	P	P	S	V	S	G	A	P	G	Q	R	V	T	I	S	C	L	G	G	S	S	N	I	G	A	G	Y	D	V	H	W	Y	Q	H	L	P	G	A	A	P	K	L	L	I	S	G	N	S	N	R	P	S	G	V	P	A	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	T	G	L	Q	A	E	D	E	A	D	Y	Y	C	Q	S	Y	D	N	D	L	S	Q	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	T
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF

CDR Sequences (chothia definition)
CDRH1	GYNFSRY
CDRH2	YPDDSD
CDRH3	FGAGMTGMPRYFDTTRWFDP
CDRL1	LGGSSNIGAGYDVH
CDRL2	GNSNRPS
CDRL3	QSYDNDLSQV

Orientation Angles (from ABangle)
HL	-53.48°
HC1	71.47°
HC2	112.0°
LC1	123.4°
LC2	83.75°
dc	16.21Å

Fv Details
Heavy chain	Y
Light chain	Z
Heavy subgroup	IGHV4
Light subgroup	IGKV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	T	C	T	V	S	S	G	S	I	S	G	T	S	Y	Y	W	D	W	I	R	Q	P	P	G	K	G	L	E	W	I	G	T	I	Y	Y	S	G	S	T	Y	Y	N	P	S	L	K	S	R	V	T	I	S	V	D	T	S	K	N	Q	F	S	L	K	L	S	P	V	T	A	A	G	T	A	V	Y	Y	C	A	R	R	T	F	Y	Y	D	R	S	G	Q	K	V	V	E	P	F	D	Y	W	G	Q	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
E	I	V	L	T	Q	S	P	S	T	L	S	A	S	V	G	D	R	V	T	I	T	C	R	A	S	Q	S	I	S	S	W	L	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	E	A	S	S	L	E	N	G	V	P	S	R	F	S	G	S	G	S	G	T	E	F	T	L	T	I	S	S	L	Q	P	D	D	F	A	T	Y	Y	C	Q	Q	Y	N	S	Y	S	L	T	F	G	G	G	T	K	V	E	I	K

Antigen Details
Antigen chains	T
Antigen type	protein
Antigen name	spike protein s1
Antigen species	SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequence	RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF

CDR Sequences (chothia definition)
CDRH1	SGSISGTSY
CDRH2	YYSGS
CDRH3	RTFYYDRSGQKVVEPFDY
CDRL1	RASQSISSWLA
CDRL2	EASSLEN
CDRL3	QQYNSYSLT

Orientation Angles (from ABangle)
HL	-60.96°
HC1	75.6°
HC2	119.79°
LC1	120.55°
LC2	81.79°
dc	16.43Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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