Structure Viewer: 8j6q

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Cryo-Em Structure of the 3-Hb and Compound 9N-Bound Human Hcar2-Gi1 complex

PDB8j6q
SpeciesSYNTHETIC CONSTRUCT
MethodELECTRON MICROSCOPY
Resolution2.6Å
Number of Fvs1
In complexTrue
Light chain typeunknown
Has constant regionFalse
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>   Fv information

This PDB has 1 Fv(s).

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Fv Details
Heavy chainS
Light chainS
Heavy subgroupunknown
Light subgroupunknown
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?True
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
D V Q L V E S G G G L V Q P G G S R K L S C S A S G F A F S S F G M H W V R Q A P E K G L E W V A Y I S S G S G T I Y Y A D T V K G R F T I S R D D P K N T L F L Q M T S L R S E D T A M Y Y C V R S I Y Y Y G S S P F D F W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 30D 30E 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I V M T Q A T S S V P V T P G E S V S I S C R S S K S L L H S N G N T Y L Y W F L Q R P G Q S P Q L L I Y R M S N L A S G V P D R F S G S G S G T A F T L T I S R L E A E D V G V Y Y C M Q H L E Y P L T F G A G T K L E L K

Antigen Details
Antigen chainsA,B
Antigen typeprotein
Antigen nameguanine nucleotide-binding protein g(i) subunit alpha-1; guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1
Antigen speciesHOMO SAPIENS
Antigen sequenceSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN/CTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKNTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGAQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHASMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCSTDTKNVQFVFDAVTDVIIKNNLKDCGLF

CDR Sequences (chothia definition)
CDRH1GFAFSSF
CDRH2SSGSGT
CDRH3SIYYYGSSPFDF
CDRL1RSSKSLLHSNGNTYLY
CDRL2RMSNLAS
CDRL3MQHLEYPLT

Orientation Angles (from ABangle)
HL-65.02°
HC171.08°
HC2120.01°
LC1122.32°
LC282.63°
dc15.96Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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