Structure Viewer: 8qz2

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Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek-2 (K2P10.1) in complex with an inhibitory Nanobody (Nb61)

PDB8qz2
SpeciesLAMA GLAMA
MethodX-RAY DIFFRACTION
Resolution3.5Å
Number of Fvs1
In complexTrue
Light chain typeNA
Has constant regionFalse
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>   Fv information

This PDB has 1 Fv(s).

>   C/-
Fv Details
Heavy chainC
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G D S L R V S C A G S G F T F T S Y G M G W F R Q A P G K E R E F V A S I N W N S N T A Y A D S V R G R F T I S R D N A E S M M Y L Q M N S L K P E D T A V Y Y C A A T R A Y S K P R V D S R H Y D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsB,A
Antigen typeprotein
Antigen namepotassium channel subfamily k member 10
Antigen speciesHOMO SAPIENS
Antigen sequenceMKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGQSSQQSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEAENLYFQ/MKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGQSSQQSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEAENLYFQ

CDR Sequences (chothia definition)
CDRH1GFTFTSY
CDRH2NWNSN
CDRH3TRAYSKPRVDSRHYDY

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Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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