Structure Viewer: 8rmk

> Structure details

Cryo-Em Structure of Human Calhm2 in complex with Synthetic Nanobody Sbc2

PDB	8rmk
Species	SYNTHETIC CONSTRUCT
Method	ELECTRON MICROSCOPY
Resolution	3.07Å
Number of Fvs	11
In complex	True
Light chain type	NA
Has constant region	False

> Fv information

This PDB has 11 Fv(s).

Fv Details
Heavy chain	L
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	S	V	Q	A	G	G	S	L	R	L	S	C	A	A	S	G	N	I	R	N	I	S	Y	L	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	A	A	L	W	T	T	Q	G	Q	T	Y	Y	A	D	S	V	K	G	R	F	T	V	S	L	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	L	Y	Y	C	A	A	A	T	S	G	Q	Y	N	P	L	R	G	Y	H	Y	N	E	Y	W	G	Q	G	T	Q	V	T	V	S	A

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	calcium homeostasis modulator protein 2
Antigen species	HOMO SAPIENS
Antigen sequence	MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

CDR Sequences (chothia definition)
CDRH1	GNIRNIS
CDRH2	WTTQGQ
CDRH3	ATSGQYNPLRGYHYNEY

Fv Details
Heavy chain	M
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	S	V	Q	A	G	G	S	L	R	L	S	C	A	A	S	G	N	I	R	N	I	S	Y	L	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	A	A	L	W	T	T	Q	G	Q	T	Y	Y	A	D	S	V	K	G	R	F	T	V	S	L	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	L	Y	Y	C	A	A	A	T	S	G	Q	Y	N	P	L	R	G	Y	H	Y	N	E	Y	W	G	Q	G	T	Q	V	T	V	S	A

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	calcium homeostasis modulator protein 2
Antigen species	HOMO SAPIENS
Antigen sequence	MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

CDR Sequences (chothia definition)
CDRH1	GNIRNIS
CDRH2	WTTQGQ
CDRH3	ATSGQYNPLRGYHYNEY

Fv Details
Heavy chain	N
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	S	V	Q	A	G	G	S	L	R	L	S	C	A	A	S	G	N	I	R	N	I	S	Y	L	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	A	A	L	W	T	T	Q	G	Q	T	Y	Y	A	D	S	V	K	G	R	F	T	V	S	L	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	L	Y	Y	C	A	A	A	T	S	G	Q	Y	N	P	L	R	G	Y	H	Y	N	E	Y	W	G	Q	G	T	Q	V	T	V	S	A

Antigen Details
Antigen chains	D
Antigen type	protein
Antigen name	calcium homeostasis modulator protein 2
Antigen species	HOMO SAPIENS
Antigen sequence	MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

CDR Sequences (chothia definition)
CDRH1	GNIRNIS
CDRH2	WTTQGQ
CDRH3	ATSGQYNPLRGYHYNEY

Fv Details
Heavy chain	O
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	S	V	Q	A	G	G	S	L	R	L	S	C	A	A	S	G	N	I	R	N	I	S	Y	L	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	A	A	L	W	T	T	Q	G	Q	T	Y	Y	A	D	S	V	K	G	R	F	T	V	S	L	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	L	Y	Y	C	A	A	A	T	S	G	Q	Y	N	P	L	R	G	Y	H	Y	N	E	Y	W	G	Q	G	T	Q	V	T	V	S	A

Antigen Details
Antigen chains	E
Antigen type	protein
Antigen name	calcium homeostasis modulator protein 2
Antigen species	HOMO SAPIENS
Antigen sequence	MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

CDR Sequences (chothia definition)
CDRH1	GNIRNIS
CDRH2	WTTQGQ
CDRH3	ATSGQYNPLRGYHYNEY

Fv Details
Heavy chain	P
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	S	V	Q	A	G	G	S	L	R	L	S	C	A	A	S	G	N	I	R	N	I	S	Y	L	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	A	A	L	W	T	T	Q	G	Q	T	Y	Y	A	D	S	V	K	G	R	F	T	V	S	L	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	L	Y	Y	C	A	A	A	T	S	G	Q	Y	N	P	L	R	G	Y	H	Y	N	E	Y	W	G	Q	G	T	Q	V	T	V	S	A

Antigen Details
Antigen chains	F
Antigen type	protein
Antigen name	calcium homeostasis modulator protein 2
Antigen species	HOMO SAPIENS
Antigen sequence	MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

CDR Sequences (chothia definition)
CDRH1	GNIRNIS
CDRH2	WTTQGQ
CDRH3	ATSGQYNPLRGYHYNEY

Fv Details
Heavy chain	Q
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	S	V	Q	A	G	G	S	L	R	L	S	C	A	A	S	G	N	I	R	N	I	S	Y	L	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	A	A	L	W	T	T	Q	G	Q	T	Y	Y	A	D	S	V	K	G	R	F	T	V	S	L	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	L	Y	Y	C	A	A	A	T	S	G	Q	Y	N	P	L	R	G	Y	H	Y	N	E	Y	W	G	Q	G	T	Q	V	T	V	S	A

Antigen Details
Antigen chains	G
Antigen type	protein
Antigen name	calcium homeostasis modulator protein 2
Antigen species	HOMO SAPIENS
Antigen sequence	MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

CDR Sequences (chothia definition)
CDRH1	GNIRNIS
CDRH2	WTTQGQ
CDRH3	ATSGQYNPLRGYHYNEY

Fv Details
Heavy chain	R
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	S	V	Q	A	G	G	S	L	R	L	S	C	A	A	S	G	N	I	R	N	I	S	Y	L	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	A	A	L	W	T	T	Q	G	Q	T	Y	Y	A	D	S	V	K	G	R	F	T	V	S	L	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	L	Y	Y	C	A	A	A	T	S	G	Q	Y	N	P	L	R	G	Y	H	Y	N	E	Y	W	G	Q	G	T	Q	V	T	V	S	A

Antigen Details
Antigen chains	H
Antigen type	protein
Antigen name	calcium homeostasis modulator protein 2
Antigen species	HOMO SAPIENS
Antigen sequence	MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

CDR Sequences (chothia definition)
CDRH1	GNIRNIS
CDRH2	WTTQGQ
CDRH3	ATSGQYNPLRGYHYNEY

Fv Details
Heavy chain	S
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	S	V	Q	A	G	G	S	L	R	L	S	C	A	A	S	G	N	I	R	N	I	S	Y	L	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	A	A	L	W	T	T	Q	G	Q	T	Y	Y	A	D	S	V	K	G	R	F	T	V	S	L	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	L	Y	Y	C	A	A	A	T	S	G	Q	Y	N	P	L	R	G	Y	H	Y	N	E	Y	W	G	Q	G	T	Q	V	T	V	S	A

Antigen Details
Antigen chains	I
Antigen type	protein
Antigen name	calcium homeostasis modulator protein 2
Antigen species	HOMO SAPIENS
Antigen sequence	MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

CDR Sequences (chothia definition)
CDRH1	GNIRNIS
CDRH2	WTTQGQ
CDRH3	ATSGQYNPLRGYHYNEY

Fv Details
Heavy chain	T
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	S	V	Q	A	G	G	S	L	R	L	S	C	A	A	S	G	N	I	R	N	I	S	Y	L	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	A	A	L	W	T	T	Q	G	Q	T	Y	Y	A	D	S	V	K	G	R	F	T	V	S	L	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	L	Y	Y	C	A	A	A	T	S	G	Q	Y	N	P	L	R	G	Y	H	Y	N	E	Y	W	G	Q	G	T	Q	V	T	V	S	A

Antigen Details
Antigen chains	J
Antigen type	protein
Antigen name	calcium homeostasis modulator protein 2
Antigen species	HOMO SAPIENS
Antigen sequence	MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

CDR Sequences (chothia definition)
CDRH1	GNIRNIS
CDRH2	WTTQGQ
CDRH3	ATSGQYNPLRGYHYNEY

Fv Details
Heavy chain	U
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	S	V	Q	A	G	G	S	L	R	L	S	C	A	A	S	G	N	I	R	N	I	S	Y	L	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	A	A	L	W	T	T	Q	G	Q	T	Y	Y	A	D	S	V	K	G	R	F	T	V	S	L	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	L	Y	Y	C	A	A	A	T	S	G	Q	Y	N	P	L	R	G	Y	H	Y	N	E	Y	W	G	Q	G	T	Q	V	T	V	S	A

Antigen Details
Antigen chains	K
Antigen type	protein
Antigen name	calcium homeostasis modulator protein 2
Antigen species	HOMO SAPIENS
Antigen sequence	MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

CDR Sequences (chothia definition)
CDRH1	GNIRNIS
CDRH2	WTTQGQ
CDRH3	ATSGQYNPLRGYHYNEY

Fv Details
Heavy chain	V
Light chain
Heavy subgroup	IGHV1
Light subgroup	NA
Species	SYNTHETIC CONSTRUCT
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	E	S	G	G	G	S	V	Q	A	G	G	S	L	R	L	S	C	A	A	S	G	N	I	R	N	I	S	Y	L	G	W	F	R	Q	A	P	G	K	E	R	E	G	V	A	A	L	W	T	T	Q	G	Q	T	Y	Y	A	D	S	V	K	G	R	F	T	V	S	L	D	N	A	K	N	T	V	Y	L	Q	M	N	S	L	K	P	E	D	T	A	L	Y	Y	C	A	A	A	T	S	G	Q	Y	N	P	L	R	G	Y	H	Y	N	E	Y	W	G	Q	G	T	Q	V	T	V	S	A

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	calcium homeostasis modulator protein 2
Antigen species	HOMO SAPIENS
Antigen sequence	MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

CDR Sequences (chothia definition)
CDRH1	GNIRNIS
CDRH2	WTTQGQ
CDRH3	ATSGQYNPLRGYHYNEY

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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