Structure Viewer: 8rmn

>   Structure details

Cryo-Em Structure of a Dimer of Decameric Human Calhm4 in complex with Synthetic Nanobody Sbc4

PDB8rmn
SpeciesSYNTHETIC CONSTRUCT
MethodELECTRON MICROSCOPY
Resolution3.8Å
Number of Fvs20
In complexTrue
Light chain typeNA
Has constant regionFalse
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>   Fv information

This PDB has 20 Fv(s).

>   U/-
Fv Details
Heavy chainU
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   V/-
Fv Details
Heavy chainV
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsB
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   W/-
Fv Details
Heavy chainW
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   X/-
Fv Details
Heavy chainX
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsD
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   Y/-
Fv Details
Heavy chainY
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   Z/-
Fv Details
Heavy chainZ
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsF
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   a/-
Fv Details
Heavy chaina
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsG
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   b/-
Fv Details
Heavy chainb
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsH
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   c/-
Fv Details
Heavy chainc
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsI
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   d/-
Fv Details
Heavy chaind
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsJ
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   e/-
Fv Details
Heavy chaine
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsK
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   f/-
Fv Details
Heavy chainf
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsL
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   g/-
Fv Details
Heavy chaing
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsM
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   h/-
Fv Details
Heavy chainh
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsN
Antigen typeprotein
Antigen namesynthetic nanobody sbc4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   i/-
Fv Details
Heavy chaini
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsO
Antigen typeprotein
Antigen namecalcium homeostasis modulator protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   j/-
Fv Details
Heavy chainj
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsP
Antigen typeprotein
Antigen namecalcium homeostasis modulator protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   k/-
Fv Details
Heavy chaink
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsQ
Antigen typeprotein
Antigen namecalcium homeostasis modulator protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   l/-
Fv Details
Heavy chainl
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsR
Antigen typeprotein
Antigen namecalcium homeostasis modulator protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   m/-
Fv Details
Heavy chainm
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsS
Antigen typeprotein
Antigen namecalcium homeostasis modulator protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   n/-
Fv Details
Heavy chainn
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesSYNTHETIC CONSTRUCT
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V E S G G G L V Q A G G S L R L S C A A S G F P V Y Y T H M R W Y R Q A P G K E R E W V A A I Y S K G A G T H Y A D S V K G R F T I S R D N A K N T V Y L Q M N S L K P E D T A V Y Y C F V G V G N S Y I G Q G T Q V T V S A

Antigen Details
Antigen chainsT
Antigen typeprotein
Antigen namecalcium homeostasis modulator protein 4
Antigen speciesHOMO SAPIENS
Antigen sequenceMSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

CDR Sequences (chothia definition)
CDRH1GFPVYYT
CDRH2YSKGAG
CDRH3GVGNSY

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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