Structure Viewer: 8sw4

> Structure details

Bg505 Gt1.1 Sosip in complex with Nhp Fabs 21N13, 21M20 and Rm20a3

PDB	8sw4
Species	MACACA
Method	ELECTRON MICROSCOPY
Resolution	2.85Å
Number of Fvs	7
In complex	True
Light chain type	Kappa,Lambda
Has constant region	False

> Fv information

This PDB has 7 Fv(s).

Fv Details
Heavy chain	H
Light chain	L
Heavy subgroup	IGHV3
Light subgroup	IGKV1
Species	MACACA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	A	K	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	S	R	S	I	M	H	W	V	R	Q	A	P	G	K	G	L	E	W	V	S	T	I	N	Y	A	G	S	T	Y	Y	A	D	S	V	R	G	R	F	V	I	S	R	D	N	S	K	N	T	L	S	L	Q	M	N	S	V	R	P	E	D	R	A	V	Y	H	C	A	K	D	K	E	G	Y	Y	S	G	G	Y	P	L	W	Y	F	D	L	W	G	P	G	T	P	V	T	I	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	V	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	K	V	S	I	T	C	R	A	S	Q	G	I	A	D	A	L	A	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	G	A	S	N	L	E	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	F	S	L	T	I	S	S	L	Q	A	E	D	F	A	V	Y	Y	C	Q	Q	R	N	S	H	P	P	T	F	G	Q	G	T	R	V	E	V	K

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	envelope glycoprotein gp41
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAPEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1	GFTFSRS
CDRH2	NYAGS
CDRH3	DKEGYYSGGYPLWYFDL
CDRL1	RASQGIADALA
CDRL2	GASNLES
CDRL3	QQRNSHPPT

Orientation Angles (from ABangle)
HL	-72.97°
HC1	71.51°
HC2	114.32°
LC1	118.54°
LC2	78.87°
dc	16.07Å

Fv Details
Heavy chain	E
Light chain	F
Heavy subgroup	IGHV3
Light subgroup	IGLV2
Species	MACACA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	101	102	103	104	105	106	107	108	109	110	111	112
E	V	Q	L	V	E	T	G	G	G	L	V	Q	P	G	G	S	L	K	L	S	C	R	A	S	G	Y	T	F	S	S	F	A	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	S	L	I	N	D	R	G	G	L	T	F	Y	V	D	S	V	K	G	R	F	T	I	S	R	D	N	S	K	N	T	L	S	L	Q	M	H	S	L	R	D	G	D	T	A	V	Y	Y	C	A	T	G	G	M	S	S	A	L	Q	S	S	K	Y	Y	F	D	F	W	G	Q	G	A	L	V	T	V	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	A	L	T	Q	P	P	S	V	S	G	S	P	G	Q	S	V	T	I	S	C	T	G	T	S	S	D	I	G	S	Y	N	Y	V	S	W	Y	Q	Q	H	P	G	K	A	P	K	L	M	I	Y	D	V	T	Q	R	P	S	G	V	S	D	R	F	S	G	S	K	S	G	N	T	A	S	L	T	I	S	G	L	Q	A	D	D	E	A	D	Y	Y	C	S	A	Y	A	G	R	Q	T	F	Y	I	F	G	G	G	T	R	L	T	V	L

Antigen Details
Antigen chains	I
Antigen type	protein
Antigen name	envelope glycoprotein gp41
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAPEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1	GYTFSSF
CDRH2	NDRGGL
CDRH3	GGMSSALQSSKYYFDF
CDRL1	TGTSSDIGSYNYVS
CDRL2	DVTQRPS
CDRL3	SAYAGRQTFYI

Orientation Angles (from ABangle)
HL	-62.62°
HC1	71.52°
HC2	118.76°
LC1	115.89°
LC2	83.27°
dc	15.55Å

Fv Details
Heavy chain	J
Light chain	M
Heavy subgroup	IGHV3
Light subgroup	IGLV2
Species	MACACA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	101	102	103	104	105	106	107	108	109	110	111	112
E	V	Q	L	V	E	T	G	G	G	L	V	Q	P	G	G	S	L	K	L	S	C	R	A	S	G	Y	T	F	S	S	F	A	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	S	L	I	N	D	R	G	G	L	T	F	Y	V	D	S	V	K	G	R	F	T	I	S	R	D	N	S	K	N	T	L	S	L	Q	M	H	S	L	R	D	G	D	T	A	V	Y	Y	C	A	T	G	G	M	S	S	A	L	Q	S	S	K	Y	Y	F	D	F	W	G	Q	G	A	L	V	T	V	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	A	L	T	Q	P	P	S	V	S	G	S	P	G	Q	S	V	T	I	S	C	T	G	T	S	S	D	I	G	S	Y	N	Y	V	S	W	Y	Q	Q	H	P	G	K	A	P	K	L	M	I	Y	D	V	T	Q	R	P	S	G	V	S	D	R	F	S	G	S	K	S	G	N	T	A	S	L	T	I	S	G	L	Q	A	D	D	E	A	D	Y	Y	C	S	A	Y	A	G	R	Q	T	F	Y	I	F	G	G	G	T	R	L	T	V	L

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	envelope glycoprotein gp41
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAPEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1	GYTFSSF
CDRH2	NDRGGL
CDRH3	GGMSSALQSSKYYFDF
CDRL1	TGTSSDIGSYNYVS
CDRL2	DVTQRPS
CDRL3	SAYAGRQTFYI

Orientation Angles (from ABangle)
HL	-62.65°
HC1	71.47°
HC2	118.4°
LC1	116.08°
LC2	83.5°
dc	15.45Å

Fv Details
Heavy chain	K
Light chain	N
Heavy subgroup	IGHV3
Light subgroup	IGLV2
Species	MACACA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	101	102	103	104	105	106	107	108	109	110	111	112
E	V	Q	L	V	E	T	G	G	G	L	V	Q	P	G	G	S	L	K	L	S	C	R	A	S	G	Y	T	F	S	S	F	A	M	S	W	V	R	Q	A	P	G	K	G	L	E	W	V	S	L	I	N	D	R	G	G	L	T	F	Y	V	D	S	V	K	G	R	F	T	I	S	R	D	N	S	K	N	T	L	S	L	Q	M	H	S	L	R	D	G	D	T	A	V	Y	Y	C	A	T	G	G	M	S	S	A	L	Q	S	S	K	Y	Y	F	D	F	W	G	Q	G	A	L	V	T	V	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	30C	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	A	L	T	Q	P	P	S	V	S	G	S	P	G	Q	S	V	T	I	S	C	T	G	T	S	S	D	I	G	S	Y	N	Y	V	S	W	Y	Q	Q	H	P	G	K	A	P	K	L	M	I	Y	D	V	T	Q	R	P	S	G	V	S	D	R	F	S	G	S	K	S	G	N	T	A	S	L	T	I	S	G	L	Q	A	D	D	E	A	D	Y	Y	C	S	A	Y	A	G	R	Q	T	F	Y	I	F	G	G	G	T	R	L	T	V	L

Antigen Details
Antigen chains	G
Antigen type	protein
Antigen name	envelope glycoprotein gp41
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	AVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAPEAQQHLLKLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD

CDR Sequences (chothia definition)
CDRH1	GYTFSSF
CDRH2	NDRGGL
CDRH3	GGMSSALQSSKYYFDF
CDRL1	TGTSSDIGSYNYVS
CDRL2	DVTQRPS
CDRL3	SAYAGRQTFYI

Orientation Angles (from ABangle)
HL	-61.39°
HC1	72.0°
HC2	118.77°
LC1	116.62°
LC2	84.12°
dc	15.57Å

Fv Details
Heavy chain	O
Light chain	P
Heavy subgroup	IGHV4
Light subgroup	IGKV1
Species	MACACA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	R	V	K	P	S	E	T	L	S	L	T	C	A	V	S	D	D	S	F	G	S	S	Y	F	Y	W	S	W	I	R	Q	A	P	G	K	G	L	E	W	I	G	Y	I	A	Y	S	G	G	V	R	Y	N	P	S	L	S	S	R	V	T	I	S	R	N	I	H	E	R	Q	F	Y	L	R	L	T	S	M	T	A	A	D	T	A	V	Y	Y	C	A	R	H	C	E	D	D	Y	G	Y	Y	S	A	A	Q	S	Y	G	L	D	S	W	G	Q	G	I	A	V	T	V	S	P

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	T	S	E	N	V	N	N	C	L	N	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	R	T	S	T	L	Q	R	G	V	P	S	R	F	S	G	T	G	S	G	T	D	Y	T	L	T	I	S	S	L	Q	S	E	D	F	G	T	Y	Y	C	Q	H	Y	Y	G	T	P	L	T	F	G	G	G	T	M	V	D	I	K

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	bg505 gt1.1 sosip gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARAENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINENQNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRRR

CDR Sequences (chothia definition)
CDRH1	DDSFGSSYF
CDRH2	AYSGG
CDRH3	HCEDDYGYYSAAQSYGLDS
CDRL1	RTSENVNNCLN
CDRL2	RTSTLQR
CDRL3	QHYYGTPLT

Orientation Angles (from ABangle)
HL	-57.28°
HC1	70.76°
HC2	118.16°
LC1	120.49°
LC2	83.69°
dc	16.4Å

Fv Details
Heavy chain	Q
Light chain	R
Heavy subgroup	IGHV4
Light subgroup	IGKV1
Species	MACACA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	R	V	K	P	S	E	T	L	S	L	T	C	A	V	S	D	D	S	F	G	S	S	Y	F	Y	W	S	W	I	R	Q	A	P	G	K	G	L	E	W	I	G	Y	I	A	Y	S	G	G	V	R	Y	N	P	S	L	S	S	R	V	T	I	S	R	N	I	H	E	R	Q	F	Y	L	R	L	T	S	M	T	A	A	D	T	A	V	Y	Y	C	A	R	H	C	E	D	D	Y	G	Y	Y	S	A	A	Q	S	Y	G	L	D	S	W	G	Q	G	I	A	V	T	V	S	P

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	T	S	E	N	V	N	N	C	L	N	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	R	T	S	T	L	Q	R	G	V	P	S	R	F	S	G	T	G	S	G	T	D	Y	T	L	T	I	S	S	L	Q	S	E	D	F	G	T	Y	Y	C	Q	H	Y	Y	G	T	P	L	T	F	G	G	G	T	M	V	D	I	K

Antigen Details
Antigen chains	D
Antigen type	protein
Antigen name	bg505 gt1.1 sosip gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARAENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINENQNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRRR

CDR Sequences (chothia definition)
CDRH1	DDSFGSSYF
CDRH2	AYSGG
CDRH3	HCEDDYGYYSAAQSYGLDS
CDRL1	RTSENVNNCLN
CDRL2	RTSTLQR
CDRL3	QHYYGTPLT

Orientation Angles (from ABangle)
HL	-56.5°
HC1	70.83°
HC2	117.77°
LC1	119.58°
LC2	83.88°
dc	16.35Å

Fv Details
Heavy chain	S
Light chain	T
Heavy subgroup	IGHV4
Light subgroup	IGKV1
Species	MACACA
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	Q	E	S	G	P	G	R	V	K	P	S	E	T	L	S	L	T	C	A	V	S	D	D	S	F	G	S	S	Y	F	Y	W	S	W	I	R	Q	A	P	G	K	G	L	E	W	I	G	Y	I	A	Y	S	G	G	V	R	Y	N	P	S	L	S	S	R	V	T	I	S	R	N	I	H	E	R	Q	F	Y	L	R	L	T	S	M	T	A	A	D	T	A	V	Y	Y	C	A	R	H	C	E	D	D	Y	G	Y	Y	S	A	A	Q	S	Y	G	L	D	S	W	G	Q	G	I	A	V	T	V	S	P

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	S	P	S	S	L	S	A	S	V	G	D	R	V	T	I	T	C	R	T	S	E	N	V	N	N	C	L	N	W	Y	Q	Q	K	P	G	K	A	P	K	L	L	I	Y	R	T	S	T	L	Q	R	G	V	P	S	R	F	S	G	T	G	S	G	T	D	Y	T	L	T	I	S	S	L	Q	S	E	D	F	G	T	Y	Y	C	Q	H	Y	Y	G	T	P	L	T	F	G	G	G	T	M	V	D	I	K

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	bg505 gt1.1 sosip gp120
Antigen species	HUMAN IMMUNODEFICIENCY VIRUS 1
Antigen sequence	MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARAENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINENQNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRRR

CDR Sequences (chothia definition)
CDRH1	DDSFGSSYF
CDRH2	AYSGG
CDRH3	HCEDDYGYYSAAQSYGLDS
CDRL1	RTSENVNNCLN
CDRL2	RTSTLQR
CDRL3	QHYYGTPLT

Orientation Angles (from ABangle)
HL	-57.59°
HC1	70.79°
HC2	118.24°
LC1	120.73°
LC2	83.84°
dc	16.23Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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