Structure Viewer: 8t6m

>   Structure details

Human Leukocyte antigen Bound By Two alloreactive antibody Fabs

PDB8t6m
SpeciesHOMO SAPIENS
MethodELECTRON MICROSCOPY
Resolution3.14Å
Number of Fvs2
In complexTrue
Light chain typeKappa
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   B/A
Fv Details
Heavy chainB
Light chainA
Heavy subgroupIGHV2
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 31A 31B 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 101 102 103 104 105 106 107 108 109 110 111 112 113
Q I T L K E S G P T L V K P T Q T L T L T C T F S G F S V N T S G V A V G W I R Q P P G K A L E W L A L I Y W D H N K R Y S P S L Q N R L T I T K D T S Q S Q V V L T M T N V D P V D T A T Y Y C G H T T G Y C S G G S C Y S G W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I N N Y L N W Y Q Q K P G K A P K L L V Y D A S N L E T G V P S R F S G S R S G T N F T F T I S S L Q P E D I A T Y S C Q H Y V N L L F T F G P G T K V D I K

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namemhc class i antigen
Antigen speciesHOMO SAPIENS
Antigen sequenceGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQR

CDR Sequences (chothia definition)
CDRH1GFSVNTSGV
CDRH2YWDHN
CDRH3TTGYCSGGSCYSGWFDP
CDRL1QASQDINNYLN
CDRL2DASNLET
CDRL3QHYVNLLFT

Orientation Angles (from ABangle)
HL-62.09°
HC174.79°
HC2117.82°
LC1120.66°
LC280.68°
dc15.93Å
>   D/C
Fv Details
Heavy chainD
Light chainC
Heavy subgroupIGHV4
Light subgroupIGKV1
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G P G L V K P S E T L S L T C T V S R G S I E S Y Y W S W I R Q P P G K G L E W I G Y I H Y T G S T K Y N P S L G T R V S I S V D T S E N Q L S L N L K S V T P A D S A V Y Y C A K V D H Y G S G V F W S F E F W G Q G K S V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D V Q L T Q S P S F V S A S V G D R I T I T C R A S Q G I K S Y L A W Y Q Q K P G K A P K L L I Y V G S S L Q S G V P S R F S G S G F G T E F T L T I T S L Q P E D F A S Y Y C Q Q L N D Y P I T F G G G T K V E I T

Antigen Details
Antigen chainsE,G
Antigen typeprotein
Antigen namemhc class i antigen; hla_a0101_peptide
Antigen speciesHOMO SAPIENS
Antigen sequenceVTEHDTLLY/GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQR

CDR Sequences (chothia definition)
CDRH1RGSIESY
CDRH2HYTGS
CDRH3VDHYGSGVFWSFEF
CDRL1RASQGIKSYLA
CDRL2VGSSLQS
CDRL3QQLNDYPIT

Orientation Angles (from ABangle)
HL-58.97°
HC172.4°
HC2118.83°
LC1120.46°
LC282.16°
dc16.3Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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