Structure Viewer: 8t7r

>   Structure details

Crystal Structure of Human Leukocyte antigen a*0101 in complex with the Fab of alloreactive antibody E07

PDB8t7r
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution3.84Å
Number of Fvs12
In complexTrue
Light chain typeLambda
Has constant regionTrue
>   Structure visualisation
Please note the WebGL plugin needs to be enabled to use PV Viewer.

Display options:














>   Fv information

This PDB has 12 Fv(s).

>   B/A
Fv Details
Heavy chainB
Light chainA
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L

Antigen Details
Antigen chainsC,0
Antigen typeprotein
Antigen namemhc class i antigen (fragment); peptide
Antigen specieshomo sapiens ; cytomegalovirus
Antigen sequenceVTEHDTLLY/GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW

CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-57.8°
HC171.09°
HC2117.87°
LC1120.57°
LC281.82°
dc16.02Å
>   F/E
Fv Details
Heavy chainF
Light chainE
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L

Antigen Details
Antigen chainsG,1
Antigen typeprotein
Antigen namemhc class i antigen (fragment); peptide
Antigen specieshomo sapiens ; cytomegalovirus
Antigen sequenceVTEHDTLLY/GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW

CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-58.97°
HC170.65°
HC2117.7°
LC1120.4°
LC281.98°
dc16.21Å
>   J/I
Fv Details
Heavy chainJ
Light chainI
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L

Antigen Details
Antigen chainsK,2
Antigen typeprotein
Antigen namemhc class i antigen (fragment); peptide
Antigen specieshomo sapiens ; cytomegalovirus
Antigen sequenceVTEHDTLLY/GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW

CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-58.69°
HC171.05°
HC2117.15°
LC1118.98°
LC281.41°
dc16.04Å
>   N/M
Fv Details
Heavy chainN
Light chainM
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L

Antigen Details
Antigen chainsO,3
Antigen typeprotein
Antigen namemhc class i antigen (fragment); peptide
Antigen specieshomo sapiens ; cytomegalovirus
Antigen sequenceVTEHDTLLY/GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW

CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-58.45°
HC171.88°
HC2117.93°
LC1119.75°
LC282.39°
dc16.12Å
>   R/Q
Fv Details
Heavy chainR
Light chainQ
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L

Antigen Details
Antigen chainsS,4
Antigen typeprotein
Antigen namemhc class i antigen (fragment); peptide
Antigen specieshomo sapiens ; cytomegalovirus
Antigen sequenceVTEHDTLLY/GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW

CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-59.32°
HC170.86°
HC2116.87°
LC1119.46°
LC280.74°
dc15.99Å
>   V/U
Fv Details
Heavy chainV
Light chainU
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L

Antigen Details
Antigen chainsW,5
Antigen typeprotein
Antigen namemhc class i antigen (fragment); peptide
Antigen specieshomo sapiens ; cytomegalovirus
Antigen sequenceVTEHDTLLY/GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW

CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-58.84°
HC171.17°
HC2117.23°
LC1119.62°
LC281.28°
dc16.07Å
>   Z/Y
Fv Details
Heavy chainZ
Light chainY
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L

Antigen Details
Antigen chainsa,6
Antigen typeprotein
Antigen nameunknown; peptide
Antigen specieshomo sapiens ; cytomegalovirus
Antigen sequenceVTEHDTLLY/GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW

CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-59.6°
HC170.57°
HC2118.01°
LC1121.08°
LC280.92°
dc15.99Å
>   d/c
Fv Details
Heavy chaind
Light chainc
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L

Antigen Details
Antigen chainse,7
Antigen typeprotein
Antigen nameunknown; peptide
Antigen specieshomo sapiens ; cytomegalovirus
Antigen sequenceVTEHDTLLY/GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW

CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-59.7°
HC171.66°
HC2117.31°
LC1120.8°
LC282.12°
dc16.27Å
>   h/g
Fv Details
Heavy chainh
Light chaing
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L

Antigen Details
Antigen chainsi,8
Antigen typeprotein
Antigen nameunknown; peptide
Antigen specieshomo sapiens ; cytomegalovirus
Antigen sequenceVTEHDTLLY/GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW

CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-59.65°
HC171.92°
HC2117.6°
LC1119.14°
LC281.33°
dc15.99Å
>   l/k
Fv Details
Heavy chainl
Light chaink
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L


CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-57.45°
HC170.95°
HC2118.08°
LC1120.16°
LC283.03°
dc16.2Å
>   p/o
Fv Details
Heavy chainp
Light chaino
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L


CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-58.47°
HC171.74°
HC2118.37°
LC1119.52°
LC282.21°
dc15.8Å
>   t/s
Fv Details
Heavy chaint
Light chains
Heavy subgroupIGHV3
Light subgroupIGLV3
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G G G V V Q P G G S L R L S C A A S G F N F S N Y G M H W V R Q T P G K G L E W V A S I P Y D G S H Q W H A D S V K G R F T I S R D N S K N T L Y L Q I N S L R P E D T A M Y Y C S K A R I S Y L S A P A W W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V S T Q P P S V S V A P G Q T A R I T C G G N N I G S K S V H W Y R Q K P G Q A P V L V V Y D N N A R P S G I P E R I S G S N F A N T A T L T I S R V E A G D E A D Y Y C H V W D S S S D H V V F G G G T K L T V L


CDR Sequences (chothia definition)
CDRH1GFNFSNY
CDRH2PYDGSH
CDRH3ARISYLSAPAWWFDP
CDRL1GGNNIGSKSVH
CDRL2DNNARPS
CDRL3HVWDSSSDHVV

Orientation Angles (from ABangle)
HL-57.83°
HC171.35°
HC2118.03°
LC1120.54°
LC282.49°
dc16.08Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

Our privacy policy