Structure Viewer: 8tp3

>   Structure details

H1 Hemagglutinin (Nc99) in complex with Rbs-Targeting Fab 1-1-1F05

PDB8tp3
SpeciesHOMO SAPIENS
MethodELECTRON MICROSCOPY
Resolution3.6Å
Number of Fvs1
In complexTrue
Light chain typeKappa
Has constant regionFalse
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>   Fv information

This PDB has 1 Fv(s).

>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV4
Light subgroupIGKV3
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G P G L V K P S A T L S L T C T L S G G S L S T H Y W S W I R Q P P G K G L E Y I G N I H Y S G S T N Y N P S L R S R V T I S V G T S K N Q F S L K L T S V T A A D T A V Y Y C A R D A P Y S D F L S G V E T G W F D P W G Q G T L V I V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
E I V M T Q S P A T L S V S P G E R A T L S C R A S Q S V S S N L A W Y Q Q K P G Q A P R L L I Y G A S T R A T G I P A R F S G S G S G T D F T L T I S S L Q S E D F A V Y S C Q Q Y N N W P W T F G Q G T K V E I K

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namehemagglutinin ha1 chain
Antigen speciesINFLUENZA A VIRUS (A/NEWCALEDONIA/20/1999(H1N1))
Antigen sequenceMKAKLLVLLCTFTATYADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVSASCSHNGKSSFYRNLLWLTGKNGLYPNLSKSYVNNKEKEVLVLWGVHHPPNIGNQRALYHTENAYVSVVSSHYSRRFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGIITSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPSIQSR

CDR Sequences (chothia definition)
CDRH1GGSLSTH
CDRH2HYSGS
CDRH3DAPYSDFLSGVETGWFDP
CDRL1RASQSVSSNLA
CDRL2GASTRAT
CDRL3QQYNNWPWT

Orientation Angles (from ABangle)
HL-70.62°
HC172.97°
HC2119.57°
LC1122.49°
LC278.46°
dc15.58Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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