Structure Viewer: 8vbn

>   Structure details

Structure of Bovine anti-Hiv Fab Else8

PDB8vbn
SpeciesBOS TAURUS
MethodX-RAY DIFFRACTION
Resolution1.83Å
Number of Fvs2
In complexFalse
Light chain typeLambda
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   H/L
Fv Details
Heavy chainH
Light chainL
Heavy subgroupIGHV1
Light subgroupIGLV1
SpeciesBOS TAURUS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (imgt)

Heavy chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 63 64 65 66 67 68 69 70 71 72 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 111A 111B 111C 111D 111E 111F 111G 111H 111I 111J 111K 111L 111M 111N 111O 111P 111Q 111R 111S 111T 111U 112 112A 112B 112C 112D 112E 112F 112G 112H 112I 112J 112K 112L 112M 112N 112O 112P 112Q 112R 112S 112T 112U 112V 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128
K V Q L Q E S G P S L V K P S Q T L S L T C T T S G F S L S D K G I A W V R Q A P G K A L E W L G S T D T T G S T N Y N P G L K S R V I V T K D N S K S Q V S L S L S S V T I A D S A T Y Y C T A V V Q E T R K S C P D G W R F G W D C G F H G Y G T E Y R D T S S V T E S S L I D V C D E Y C D E L H V D A W G Q G L L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 65 66 67 68 69 70 71 72 74 75 76 77 78 79 80 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127
Q A V L N Q P S S V S G S L G Q R V S I T C S G S S S N V G N G Y V S W Y Q L I P G S A P R T L I Y G D T S R A S G V P D R F S G S R S G N T A T L T I S S L Q A E D E A D Y F C A S A E D S S S N A V F G S G T T L T V L


CDR Sequences (imgt definition)
CDRH1GFSLSDKG
CDRH2TDTTGST
CDRH3TAVVQETRKSCPDGWRFGWDCGFHGYGTEDCYEDCVDILSSETVSSTDRYELHVDA
CDRL1SSNVGNGY
CDRL2GDT
CDRL3ASAEDSSSNAV

Orientation Angles (from ABangle)
HL-57.37°
HC172.37°
HC2120.43°
LC1116.68°
LC284.02°
dc15.73Å
>   B/A
Fv Details
Heavy chainB
Light chainA
Heavy subgroupIGHV1
Light subgroupIGLV1
SpeciesBOS TAURUS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (imgt)

Heavy chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 63 64 65 66 67 68 69 70 71 72 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 111A 111B 111C 111D 111E 111F 111G 111H 111I 111J 111K 111L 111M 111N 111O 111P 111Q 111R 111S 111T 111U 112 112A 112B 112C 112D 112E 112F 112G 112H 112I 112J 112K 112L 112M 112N 112O 112P 112Q 112R 112S 112T 112U 112V 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128
K V Q L Q E S G P S L V K P S Q T L S L T C T T S G F S L S D K G I A W V R Q A P G K A L E W L G S T D T T G S T N Y N P G L K S R V I V T K D N S K S Q V S L S L S S V T I A D S A T Y Y C T A V V Q E T R K S C P D G W R F G W D C G F H G Y G T E Y R D T S S V T E S S L I D V C D E Y C D E L H V D A W G Q G L L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 65 66 67 68 69 70 71 72 74 75 76 77 78 79 80 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127
Q A V L N Q P S S V S G S L G Q R V S I T C S G S S S N V G N G Y V S W Y Q L I P G S A P R T L I Y G D T S R A S G V P D R F S G S R S G N T A T L T I S S L Q A E D E A D Y F C A S A E D S S S N A V F G S G T T L T V L


CDR Sequences (imgt definition)
CDRH1GFSLSDKG
CDRH2TDTTGST
CDRH3TAVVQETRKSCPDGWRFGWDCGFHGYGTEDCYEDCVDILSSETVSSTDRYELHVDA
CDRL1SSNVGNGY
CDRL2GDT
CDRL3ASAEDSSSNAV

Orientation Angles (from ABangle)
HL-53.08°
HC173.07°
HC2121.85°
LC1118.98°
LC287.01°
dc15.59Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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