Structure Viewer: 8vs8

>   Structure details

Crystal Structure of adi-19425 Fab in complex with anti-Idiotypic 1D3 Fab

PDB8vs8
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution2.67Å
Number of Fvs16
In complexFalse
Light chain typeKappa,Lambda
Has constant regionTrue
>   Structure visualisation
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>   Fv information

This PDB has 16 Fv(s).

>   A/B
Fv Details
Heavy chainA
Light chainB
Heavy subgroupIGHV3
Light subgroupIGLV1
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V K P G G S L R L S C A A S G F T F S S Y S M N W V R Q A P G K G L E W V S S I S S S S S Y I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A R L G Y C S G G S C H F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
Q P V L T Q P P S V S G A P G Q R V T I S C T G S S S N I G A G Y D V H W Y Q Q L P G T A P K L L I Y G N S N R P S G V P D R F S G S K S G T S A S L A I T G L Q A E D E A D Y Y C Q S Y D S S L S G F Y V F G T G T K L T V L


CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2SSSSSY
CDRH3LGYCSGGSCHFDY
CDRL1TGSSSNIGAGYDVH
CDRL2GNSNRPS
CDRL3QSYDSSLSGFYV

Orientation Angles (from ABangle)
HL-60.76°
HC173.05°
HC2116.87°
LC1116.92°
LC280.77°
dc15.64Å
>   D/C
Fv Details
Heavy chainD
Light chainC
Heavy subgroupIGHV1
Light subgroupIGKV5
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q I Q Q S G A E L M R P G A S V K L S C K A T G Y T F T G Y W I E W V K Q R P G H G L E W I G E I L S G R G T T N Y N E K F K G K A T F T A D T Y S N T A Y M Q L S S L T T G D S A I Y Y C A R G G F L Y G D G P F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I L L T Q S P A I L S V S P G E R V S F S C R A S Q N I D T H I H W Y Q Q R T N G S P R L L I K Y A S E S I S G I P S R F S G S G S G T D F T L T I N S V E S E D I A D Y Y C Q Q S N S W P F T F G S G T K L E I K


CDR Sequences (chothia definition)
CDRH1GYTFTGY
CDRH2LSGRGT
CDRH3GGFLYGDGPFDY
CDRL1RASQNIDTHIH
CDRL2YASESIS
CDRL3QQSNSWPFT

Orientation Angles (from ABangle)
HL-60.05°
HC169.7°
HC2115.3°
LC1122.12°
LC282.75°
dc16.19Å
>   E/F
Fv Details
Heavy chainE
Light chainF
Heavy subgroupIGHV3
Light subgroupIGLV1
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V K P G G S L R L S C A A S G F T F S S Y S M N W V R Q A P G K G L E W V S S I S S S S S Y I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A R L G Y C S G G S C H F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
Q P V L T Q P P S V S G A P G Q R V T I S C T G S S S N I G A G Y D V H W Y Q Q L P G T A P K L L I Y G N S N R P S G V P D R F S G S K S G T S A S L A I T G L Q A E D E A D Y Y C Q S Y D S S L S G F Y V F G T G T K L T V L


CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2SSSSSY
CDRH3LGYCSGGSCHFDY
CDRL1TGSSSNIGAGYDVH
CDRL2GNSNRPS
CDRL3QSYDSSLSGFYV

Orientation Angles (from ABangle)
HL-58.29°
HC173.27°
HC2116.65°
LC1117.43°
LC281.71°
dc15.77Å
>   H/G
Fv Details
Heavy chainH
Light chainG
Heavy subgroupIGHV1
Light subgroupIGKV5
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q I Q Q S G A E L M R P G A S V K L S C K A T G Y T F T G Y W I E W V K Q R P G H G L E W I G E I L S G R G T T N Y N E K F K G K A T F T A D T Y S N T A Y M Q L S S L T T G D S A I Y Y C A R G G F L Y G D G P F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I L L T Q S P A I L S V S P G E R V S F S C R A S Q N I D T H I H W Y Q Q R T N G S P R L L I K Y A S E S I S G I P S R F S G S G S G T D F T L T I N S V E S E D I A D Y Y C Q Q S N S W P F T F G S G T K L E I K


CDR Sequences (chothia definition)
CDRH1GYTFTGY
CDRH2LSGRGT
CDRH3GGFLYGDGPFDY
CDRL1RASQNIDTHIH
CDRL2YASESIS
CDRL3QQSNSWPFT

Orientation Angles (from ABangle)
HL-59.54°
HC169.61°
HC2115.36°
LC1122.46°
LC283.91°
dc16.29Å
>   I/J
Fv Details
Heavy chainI
Light chainJ
Heavy subgroupIGHV3
Light subgroupIGLV1
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V K P G G S L R L S C A A S G F T F S S Y S M N W V R Q A P G K G L E W V S S I S S S S S Y I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A R L G Y C S G G S C H F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
Q P V L T Q P P S V S G A P G Q R V T I S C T G S S S N I G A G Y D V H W Y Q Q L P G T A P K L L I Y G N S N R P S G V P D R F S G S K S G T S A S L A I T G L Q A E D E A D Y Y C Q S Y D S S L S G F Y V F G T G T K L T V L


CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2SSSSSY
CDRH3LGYCSGGSCHFDY
CDRL1TGSSSNIGAGYDVH
CDRL2GNSNRPS
CDRL3QSYDSSLSGFYV

Orientation Angles (from ABangle)
HL-59.12°
HC173.12°
HC2117.91°
LC1118.52°
LC281.89°
dc15.69Å
>   L/K
Fv Details
Heavy chainL
Light chainK
Heavy subgroupIGHV1
Light subgroupIGKV5
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q I Q Q S G A E L M R P G A S V K L S C K A T G Y T F T G Y W I E W V K Q R P G H G L E W I G E I L S G R G T T N Y N E K F K G K A T F T A D T Y S N T A Y M Q L S S L T T G D S A I Y Y C A R G G F L Y G D G P F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I L L T Q S P A I L S V S P G E R V S F S C R A S Q N I D T H I H W Y Q Q R T N G S P R L L I K Y A S E S I S G I P S R F S G S G S G T D F T L T I N S V E S E D I A D Y Y C Q Q S N S W P F T F G S G T K L E I K


CDR Sequences (chothia definition)
CDRH1GYTFTGY
CDRH2LSGRGT
CDRH3GGFLYGDGPFDY
CDRL1RASQNIDTHIH
CDRL2YASESIS
CDRL3QQSNSWPFT

Orientation Angles (from ABangle)
HL-59.87°
HC169.38°
HC2114.67°
LC1122.81°
LC283.74°
dc16.26Å
>   M/N
Fv Details
Heavy chainM
Light chainN
Heavy subgroupIGHV3
Light subgroupIGLV1
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V K P G G S L R L S C A A S G F T F S S Y S M N W V R Q A P G K G L E W V S S I S S S S S Y I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A R L G Y C S G G S C H F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
Q P V L T Q P P S V S G A P G Q R V T I S C T G S S S N I G A G Y D V H W Y Q Q L P G T A P K L L I Y G N S N R P S G V P D R F S G S K S G T S A S L A I T G L Q A E D E A D Y Y C Q S Y D S S L S G F Y V F G T G T K L T V L


CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2SSSSSY
CDRH3LGYCSGGSCHFDY
CDRL1TGSSSNIGAGYDVH
CDRL2GNSNRPS
CDRL3QSYDSSLSGFYV

Orientation Angles (from ABangle)
HL-59.51°
HC173.03°
HC2116.97°
LC1118.73°
LC280.45°
dc15.66Å
>   P/O
Fv Details
Heavy chainP
Light chainO
Heavy subgroupIGHV1
Light subgroupIGKV5
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q I Q Q S G A E L M R P G A S V K L S C K A T G Y T F T G Y W I E W V K Q R P G H G L E W I G E I L S G R G T T N Y N E K F K G K A T F T A D T Y S N T A Y M Q L S S L T T G D S A I Y Y C A R G G F L Y G D G P F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I L L T Q S P A I L S V S P G E R V S F S C R A S Q N I D T H I H W Y Q Q R T N G S P R L L I K Y A S E S I S G I P S R F S G S G S G T D F T L T I N S V E S E D I A D Y Y C Q Q S N S W P F T F G S G T K L E I K


CDR Sequences (chothia definition)
CDRH1GYTFTGY
CDRH2LSGRGT
CDRH3GGFLYGDGPFDY
CDRL1RASQNIDTHIH
CDRL2YASESIS
CDRL3QQSNSWPFT

Orientation Angles (from ABangle)
HL-60.13°
HC169.48°
HC2114.61°
LC1121.45°
LC283.12°
dc16.26Å
>   Q/R
Fv Details
Heavy chainQ
Light chainR
Heavy subgroupIGHV3
Light subgroupIGLV1
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V K P G G S L R L S C A A S G F T F S S Y S M N W V R Q A P G K G L E W V S S I S S S S S Y I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A R L G Y C S G G S C H F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
Q P V L T Q P P S V S G A P G Q R V T I S C T G S S S N I G A G Y D V H W Y Q Q L P G T A P K L L I Y G N S N R P S G V P D R F S G S K S G T S A S L A I T G L Q A E D E A D Y Y C Q S Y D S S L S G F Y V F G T G T K L T V L


CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2SSSSSY
CDRH3LGYCSGGSCHFDY
CDRL1TGSSSNIGAGYDVH
CDRL2GNSNRPS
CDRL3QSYDSSLSGFYV

Orientation Angles (from ABangle)
HL-60.51°
HC173.27°
HC2116.95°
LC1118.46°
LC281.11°
dc15.7Å
>   T/S
Fv Details
Heavy chainT
Light chainS
Heavy subgroupIGHV1
Light subgroupIGKV5
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q I Q Q S G A E L M R P G A S V K L S C K A T G Y T F T G Y W I E W V K Q R P G H G L E W I G E I L S G R G T T N Y N E K F K G K A T F T A D T Y S N T A Y M Q L S S L T T G D S A I Y Y C A R G G F L Y G D G P F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I L L T Q S P A I L S V S P G E R V S F S C R A S Q N I D T H I H W Y Q Q R T N G S P R L L I K Y A S E S I S G I P S R F S G S G S G T D F T L T I N S V E S E D I A D Y Y C Q Q S N S W P F T F G S G T K L E I K


CDR Sequences (chothia definition)
CDRH1GYTFTGY
CDRH2LSGRGT
CDRH3GGFLYGDGPFDY
CDRL1RASQNIDTHIH
CDRL2YASESIS
CDRL3QQSNSWPFT

Orientation Angles (from ABangle)
HL-60.1°
HC169.36°
HC2114.24°
LC1122.23°
LC282.4°
dc16.3Å
>   U/V
Fv Details
Heavy chainU
Light chainV
Heavy subgroupIGHV3
Light subgroupIGLV1
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V K P G G S L R L S C A A S G F T F S S Y S M N W V R Q A P G K G L E W V S S I S S S S S Y I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A R L G Y C S G G S C H F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
Q P V L T Q P P S V S G A P G Q R V T I S C T G S S S N I G A G Y D V H W Y Q Q L P G T A P K L L I Y G N S N R P S G V P D R F S G S K S G T S A S L A I T G L Q A E D E A D Y Y C Q S Y D S S L S G F Y V F G T G T K L T V L


CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2SSSSSY
CDRH3LGYCSGGSCHFDY
CDRL1TGSSSNIGAGYDVH
CDRL2GNSNRPS
CDRL3QSYDSSLSGFYV

Orientation Angles (from ABangle)
HL-60.24°
HC172.55°
HC2116.48°
LC1118.64°
LC281.57°
dc15.69Å
>   X/W
Fv Details
Heavy chainX
Light chainW
Heavy subgroupIGHV1
Light subgroupIGKV5
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q I Q Q S G A E L M R P G A S V K L S C K A T G Y T F T G Y W I E W V K Q R P G H G L E W I G E I L S G R G T T N Y N E K F K G K A T F T A D T Y S N T A Y M Q L S S L T T G D S A I Y Y C A R G G F L Y G D G P F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I L L T Q S P A I L S V S P G E R V S F S C R A S Q N I D T H I H W Y Q Q R T N G S P R L L I K Y A S E S I S G I P S R F S G S G S G T D F T L T I N S V E S E D I A D Y Y C Q Q S N S W P F T F G S G T K L E I K


CDR Sequences (chothia definition)
CDRH1GYTFTGY
CDRH2LSGRGT
CDRH3GGFLYGDGPFDY
CDRL1RASQNIDTHIH
CDRL2YASESIS
CDRL3QQSNSWPFT

Orientation Angles (from ABangle)
HL-60.91°
HC169.79°
HC2114.25°
LC1120.63°
LC283.22°
dc16.3Å
>   Y/Z
Fv Details
Heavy chainY
Light chainZ
Heavy subgroupIGHV3
Light subgroupIGLV1
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V K P G G S L R L S C A A S G F T F S S Y S M N W V R Q A P G K G L E W V S S I S S S S S Y I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A R L G Y C S G G S C H F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
Q P V L T Q P P S V S G A P G Q R V T I S C T G S S S N I G A G Y D V H W Y Q Q L P G T A P K L L I Y G N S N R P S G V P D R F S G S K S G T S A S L A I T G L Q A E D E A D Y Y C Q S Y D S S L S G F Y V F G T G T K L T V L


CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2SSSSSY
CDRH3LGYCSGGSCHFDY
CDRL1TGSSSNIGAGYDVH
CDRL2GNSNRPS
CDRL3QSYDSSLSGFYV

Orientation Angles (from ABangle)
HL-59.75°
HC173.33°
HC2117.34°
LC1118.39°
LC281.08°
dc15.64Å
>   b/a
Fv Details
Heavy chainb
Light chaina
Heavy subgroupIGHV1
Light subgroupIGKV5
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q I Q Q S G A E L M R P G A S V K L S C K A T G Y T F T G Y W I E W V K Q R P G H G L E W I G E I L S G R G T T N Y N E K F K G K A T F T A D T Y S N T A Y M Q L S S L T T G D S A I Y Y C A R G G F L Y G D G P F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I L L T Q S P A I L S V S P G E R V S F S C R A S Q N I D T H I H W Y Q Q R T N G S P R L L I K Y A S E S I S G I P S R F S G S G S G T D F T L T I N S V E S E D I A D Y Y C Q Q S N S W P F T F G S G T K L E I K


CDR Sequences (chothia definition)
CDRH1GYTFTGY
CDRH2LSGRGT
CDRH3GGFLYGDGPFDY
CDRL1RASQNIDTHIH
CDRL2YASESIS
CDRL3QQSNSWPFT

Orientation Angles (from ABangle)
HL-59.66°
HC169.12°
HC2114.52°
LC1121.87°
LC282.74°
dc16.25Å
>   c/d
Fv Details
Heavy chainc
Light chaind
Heavy subgroupIGHV3
Light subgroupIGLV1
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V K P G G S L R L S C A A S G F T F S S Y S M N W V R Q A P G K G L E W V S S I S S S S S Y I Y Y A D S V K G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A R L G Y C S G G S C H F D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
Q P V L T Q P P S V S G A P G Q R V T I S C T G S S S N I G A G Y D V H W Y Q Q L P G T A P K L L I Y G N S N R P S G V P D R F S G S K S G T S A S L A I T G L Q A E D E A D Y Y C Q S Y D S S L S G F Y V F G T G T K L T V L


CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2SSSSSY
CDRH3LGYCSGGSCHFDY
CDRL1TGSSSNIGAGYDVH
CDRL2GNSNRPS
CDRL3QSYDSSLSGFYV

Orientation Angles (from ABangle)
HL-58.82°
HC173.63°
HC2118.19°
LC1117.39°
LC281.94°
dc15.96Å
>   f/e
Fv Details
Heavy chainf
Light chaine
Heavy subgroupIGHV1
Light subgroupIGKV5
SpeciesHOMO SAPIENS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q I Q Q S G A E L M R P G A S V K L S C K A T G Y T F T G Y W I E W V K Q R P G H G L E W I G E I L S G R G T T N Y N E K F K G K A T F T A D T Y S N T A Y M Q L S S L T T G D S A I Y Y C A R G G F L Y G D G P F D Y W G Q G T T L T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I L L T Q S P A I L S V S P G E R V S F S C R A S Q N I D T H I H W Y Q Q R T N G S P R L L I K Y A S E S I S G I P S R F S G S G S G T D F T L T I N S V E S E D I A D Y Y C Q Q S N S W P F T F G S G T K L E I K


CDR Sequences (chothia definition)
CDRH1GYTFTGY
CDRH2LSGRGT
CDRH3GGFLYGDGPFDY
CDRL1RASQNIDTHIH
CDRL2YASESIS
CDRL3QQSNSWPFT

Orientation Angles (from ABangle)
HL-59.18°
HC169.85°
HC2115.33°
LC1119.67°
LC282.99°
dc16.38Å
>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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