Structure Viewer: 8vyn

> Structure details

Soluble Ectodomain of Human Cytomegalovirus (Hcmv) Glycoprotein B (Gb) Stabilized in a Prefusion-Like Conformation in complex with 1G2 and 7H3, Composite Map (Global and Local) and Model

PDB	8vyn
Species	HOMO SAPIENS
Method	ELECTRON MICROSCOPY
Resolution	2.8Å
Number of Fvs	6
In complex	True
Light chain type	Lambda
Has constant region	True

> Fv information

This PDB has 6 Fv(s).

Fv Details
Heavy chain	D
Light chain	E
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	N	P	G	A	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	D	Y	Y	I	H	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	W	F	N	P	N	S	G	G	T	N	F	V	Q	N	F	Q	G	R	V	T	M	T	R	D	T	S	I	S	T	A	Y	M	E	L	S	R	L	R	S	D	D	T	A	M	Y	Y	C	A	K	D	S	A	K	T	A	S	A	Y	Y	G	L	N	F	F	Y	Y	G	M	D	V	W	G	Q	G	T	T	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	V	L	S	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	S	G	S	S	S	N	I	G	K	N	Y	V	Y	W	Y	Q	Q	V	P	G	T	A	P	K	L	L	M	F	K	N	N	Q	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	R	S	E	D	E	A	D	Y	Y	C	S	A	W	D	G	S	L	S	R	P	L	F	G	G	G	T	K	V	T	V	L

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	envelope glycoprotein b
Antigen species	HUMAN BETAHERPESVIRUS 5
Antigen sequence	MESRIWCLVVCVNLCIVCLGAAVSSSSTRGTSATHSHHSSHTTSAAHSRSGSVSQRVTSSQTVSHGVNETIYNTTLKYGDVVGVNTTKYPYRVCSMAQGLDLIRFERNIVCTSMKPINEDLDEGIMVVYKRNICAHTFKVRVYQKVLTFRRSYAYIHTTYLLGSNTEYVAPPMWEIHHINSHSQCYSSYSRVIAGTVFVAYHRDSYENKTMQLMPDDYSNTCSTRYVTVKDQWHSRGSTWLYRETSNLNCMVTITTARSKYPYHFFITSTGDVVDISPFYNGTNRNASYFGENADKFFIFPNYTIVSDFGRPNSALETHRLVAFLERADSVISWDIQDEKNVTCQLTFWEASERTIRSEAEDSYHFSSAKMTATFLSKKQEVNMSDSALDCVRDEAINKLQQIFNTSYNQTYEKYGNVSVFETTGGLVVFWQGIKQKSLVELERLANRSSLNLTHNSTKSSTDGNNATHLSNMESVHNLVYAQLQFTYDTLRGYINRALAQIAEAWCVDQRRTLEVFKELSKINPSAILSAIYNKPIAARFMGDVLGLASCVTINQTSVKVLRDMNVKESPGRCYSRPVVIFNFANSSYVQYGQLGEDNEILLGNHRTEECQLPSLKIFIAGNSAYEYVDYLFKRMIDLSSISTVDSMIALDCDPLCNTDFRVLELYSQKELRSSNVFDLEEIMREFNSYKQRVKYVEDKVVDPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGAAASLEVLFQGPGHHHHHHHHSAWSHPQFEKGGASGGGGSGGSAWSHPQFEK

CDR Sequences (chothia definition)
CDRH1	GYTFTDY
CDRH2	NPNSGG
CDRH3	DSAKTASAYYGLNFFYYGMDV
CDRL1	SGSSSNIGKNYVY
CDRL2	KNNQRPS
CDRL3	SAWDGSLSRPL

Orientation Angles (from ABangle)
HL	-56.94°
HC1	72.81°
HC2	112.81°
LC1	123.22°
LC2	83.63°
dc	16.1Å

Fv Details
Heavy chain	F
Light chain	G
Heavy subgroup	IGHV4
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	L	Q	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	T	C	T	V	S	G	A	S	I	D	R	S	T	Y	Y	W	G	W	I	R	Q	P	P	G	K	G	L	E	W	I	A	N	I	Y	Y	N	G	R	A	V	Y	S	P	S	L	K	S	R	V	T	I	S	V	D	T	S	K	N	Q	F	S	L	K	V	R	S	L	T	A	A	D	T	A	V	Y	Y	C	A	T	R	W	N	Y	F	F	D	F	D	Y	W	G	R	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	S	G	S	S	S	N	I	E	T	N	Y	V	S	W	Y	Q	Q	F	P	G	T	A	P	K	L	L	I	Y	R	N	N	Q	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	R	S	E	D	E	A	E	Y	Y	C	G	T	W	D	D	N	S	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	envelope glycoprotein b
Antigen species	HUMAN BETAHERPESVIRUS 5
Antigen sequence	MESRIWCLVVCVNLCIVCLGAAVSSSSTRGTSATHSHHSSHTTSAAHSRSGSVSQRVTSSQTVSHGVNETIYNTTLKYGDVVGVNTTKYPYRVCSMAQGLDLIRFERNIVCTSMKPINEDLDEGIMVVYKRNICAHTFKVRVYQKVLTFRRSYAYIHTTYLLGSNTEYVAPPMWEIHHINSHSQCYSSYSRVIAGTVFVAYHRDSYENKTMQLMPDDYSNTCSTRYVTVKDQWHSRGSTWLYRETSNLNCMVTITTARSKYPYHFFITSTGDVVDISPFYNGTNRNASYFGENADKFFIFPNYTIVSDFGRPNSALETHRLVAFLERADSVISWDIQDEKNVTCQLTFWEASERTIRSEAEDSYHFSSAKMTATFLSKKQEVNMSDSALDCVRDEAINKLQQIFNTSYNQTYEKYGNVSVFETTGGLVVFWQGIKQKSLVELERLANRSSLNLTHNSTKSSTDGNNATHLSNMESVHNLVYAQLQFTYDTLRGYINRALAQIAEAWCVDQRRTLEVFKELSKINPSAILSAIYNKPIAARFMGDVLGLASCVTINQTSVKVLRDMNVKESPGRCYSRPVVIFNFANSSYVQYGQLGEDNEILLGNHRTEECQLPSLKIFIAGNSAYEYVDYLFKRMIDLSSISTVDSMIALDCDPLCNTDFRVLELYSQKELRSSNVFDLEEIMREFNSYKQRVKYVEDKVVDPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGAAASLEVLFQGPGHHHHHHHHSAWSHPQFEKGGASGGGGSGGSAWSHPQFEK

CDR Sequences (chothia definition)
CDRH1	GASIDRSTY
CDRH2	YYNGR
CDRH3	RWNYFFDFDY
CDRL1	SGSSSNIETNYVS
CDRL2	RNNQRPS
CDRL3	GTWDDNSWV

Orientation Angles (from ABangle)
HL	-55.03°
HC1	73.34°
HC2	121.55°
LC1	121.58°
LC2	79.77°
dc	16.18Å

Fv Details
Heavy chain	H
Light chain	I
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	N	P	G	A	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	D	Y	Y	I	H	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	W	F	N	P	N	S	G	G	T	N	F	V	Q	N	F	Q	G	R	V	T	M	T	R	D	T	S	I	S	T	A	Y	M	E	L	S	R	L	R	S	D	D	T	A	M	Y	Y	C	A	K	D	S	A	K	T	A	S	A	Y	Y	G	L	N	F	F	Y	Y	G	M	D	V	W	G	Q	G	T	T	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	V	L	S	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	S	G	S	S	S	N	I	G	K	N	Y	V	Y	W	Y	Q	Q	V	P	G	T	A	P	K	L	L	M	F	K	N	N	Q	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	R	S	E	D	E	A	D	Y	Y	C	S	A	W	D	G	S	L	S	R	P	L	F	G	G	G	T	K	V	T	V	L

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	envelope glycoprotein b
Antigen species	HUMAN BETAHERPESVIRUS 5
Antigen sequence	MESRIWCLVVCVNLCIVCLGAAVSSSSTRGTSATHSHHSSHTTSAAHSRSGSVSQRVTSSQTVSHGVNETIYNTTLKYGDVVGVNTTKYPYRVCSMAQGLDLIRFERNIVCTSMKPINEDLDEGIMVVYKRNICAHTFKVRVYQKVLTFRRSYAYIHTTYLLGSNTEYVAPPMWEIHHINSHSQCYSSYSRVIAGTVFVAYHRDSYENKTMQLMPDDYSNTCSTRYVTVKDQWHSRGSTWLYRETSNLNCMVTITTARSKYPYHFFITSTGDVVDISPFYNGTNRNASYFGENADKFFIFPNYTIVSDFGRPNSALETHRLVAFLERADSVISWDIQDEKNVTCQLTFWEASERTIRSEAEDSYHFSSAKMTATFLSKKQEVNMSDSALDCVRDEAINKLQQIFNTSYNQTYEKYGNVSVFETTGGLVVFWQGIKQKSLVELERLANRSSLNLTHNSTKSSTDGNNATHLSNMESVHNLVYAQLQFTYDTLRGYINRALAQIAEAWCVDQRRTLEVFKELSKINPSAILSAIYNKPIAARFMGDVLGLASCVTINQTSVKVLRDMNVKESPGRCYSRPVVIFNFANSSYVQYGQLGEDNEILLGNHRTEECQLPSLKIFIAGNSAYEYVDYLFKRMIDLSSISTVDSMIALDCDPLCNTDFRVLELYSQKELRSSNVFDLEEIMREFNSYKQRVKYVEDKVVDPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGAAASLEVLFQGPGHHHHHHHHSAWSHPQFEKGGASGGGGSGGSAWSHPQFEK

CDR Sequences (chothia definition)
CDRH1	GYTFTDY
CDRH2	NPNSGG
CDRH3	DSAKTASAYYGLNFFYYGMDV
CDRL1	SGSSSNIGKNYVY
CDRL2	KNNQRPS
CDRL3	SAWDGSLSRPL

Orientation Angles (from ABangle)
HL	-56.85°
HC1	72.86°
HC2	112.74°
LC1	123.18°
LC2	83.6°
dc	16.09Å

Fv Details
Heavy chain	J
Light chain	K
Heavy subgroup	IGHV4
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	L	Q	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	T	C	T	V	S	G	A	S	I	D	R	S	T	Y	Y	W	G	W	I	R	Q	P	P	G	K	G	L	E	W	I	A	N	I	Y	Y	N	G	R	A	V	Y	S	P	S	L	K	S	R	V	T	I	S	V	D	T	S	K	N	Q	F	S	L	K	V	R	S	L	T	A	A	D	T	A	V	Y	Y	C	A	T	R	W	N	Y	F	F	D	F	D	Y	W	G	R	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	S	G	S	S	S	N	I	E	T	N	Y	V	S	W	Y	Q	Q	F	P	G	T	A	P	K	L	L	I	Y	R	N	N	Q	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	R	S	E	D	E	A	E	Y	Y	C	G	T	W	D	D	N	S	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	envelope glycoprotein b
Antigen species	HUMAN BETAHERPESVIRUS 5
Antigen sequence	MESRIWCLVVCVNLCIVCLGAAVSSSSTRGTSATHSHHSSHTTSAAHSRSGSVSQRVTSSQTVSHGVNETIYNTTLKYGDVVGVNTTKYPYRVCSMAQGLDLIRFERNIVCTSMKPINEDLDEGIMVVYKRNICAHTFKVRVYQKVLTFRRSYAYIHTTYLLGSNTEYVAPPMWEIHHINSHSQCYSSYSRVIAGTVFVAYHRDSYENKTMQLMPDDYSNTCSTRYVTVKDQWHSRGSTWLYRETSNLNCMVTITTARSKYPYHFFITSTGDVVDISPFYNGTNRNASYFGENADKFFIFPNYTIVSDFGRPNSALETHRLVAFLERADSVISWDIQDEKNVTCQLTFWEASERTIRSEAEDSYHFSSAKMTATFLSKKQEVNMSDSALDCVRDEAINKLQQIFNTSYNQTYEKYGNVSVFETTGGLVVFWQGIKQKSLVELERLANRSSLNLTHNSTKSSTDGNNATHLSNMESVHNLVYAQLQFTYDTLRGYINRALAQIAEAWCVDQRRTLEVFKELSKINPSAILSAIYNKPIAARFMGDVLGLASCVTINQTSVKVLRDMNVKESPGRCYSRPVVIFNFANSSYVQYGQLGEDNEILLGNHRTEECQLPSLKIFIAGNSAYEYVDYLFKRMIDLSSISTVDSMIALDCDPLCNTDFRVLELYSQKELRSSNVFDLEEIMREFNSYKQRVKYVEDKVVDPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGAAASLEVLFQGPGHHHHHHHHSAWSHPQFEKGGASGGGGSGGSAWSHPQFEK

CDR Sequences (chothia definition)
CDRH1	GASIDRSTY
CDRH2	YYNGR
CDRH3	RWNYFFDFDY
CDRL1	SGSSSNIETNYVS
CDRL2	RNNQRPS
CDRL3	GTWDDNSWV

Orientation Angles (from ABangle)
HL	-55.02°
HC1	73.39°
HC2	121.62°
LC1	121.45°
LC2	79.85°
dc	16.17Å

Fv Details
Heavy chain	L
Light chain	M
Heavy subgroup	IGHV1
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	100C	100D	100E	100F	100G	100H	100I	100J	100K	100L	100M	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	V	Q	L	V	Q	S	G	A	E	V	K	N	P	G	A	S	V	K	V	S	C	K	A	S	G	Y	T	F	T	D	Y	Y	I	H	W	V	R	Q	A	P	G	Q	G	L	E	W	M	G	W	F	N	P	N	S	G	G	T	N	F	V	Q	N	F	Q	G	R	V	T	M	T	R	D	T	S	I	S	T	A	Y	M	E	L	S	R	L	R	S	D	D	T	A	M	Y	Y	C	A	K	D	S	A	K	T	A	S	A	Y	Y	G	L	N	F	F	Y	Y	G	M	D	V	W	G	Q	G	T	T	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	95A	95B	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	V	L	S	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	S	G	S	S	S	N	I	G	K	N	Y	V	Y	W	Y	Q	Q	V	P	G	T	A	P	K	L	L	M	F	K	N	N	Q	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	R	S	E	D	E	A	D	Y	Y	C	S	A	W	D	G	S	L	S	R	P	L	F	G	G	G	T	K	V	T	V	L

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	envelope glycoprotein b
Antigen species	HUMAN BETAHERPESVIRUS 5
Antigen sequence	MESRIWCLVVCVNLCIVCLGAAVSSSSTRGTSATHSHHSSHTTSAAHSRSGSVSQRVTSSQTVSHGVNETIYNTTLKYGDVVGVNTTKYPYRVCSMAQGLDLIRFERNIVCTSMKPINEDLDEGIMVVYKRNICAHTFKVRVYQKVLTFRRSYAYIHTTYLLGSNTEYVAPPMWEIHHINSHSQCYSSYSRVIAGTVFVAYHRDSYENKTMQLMPDDYSNTCSTRYVTVKDQWHSRGSTWLYRETSNLNCMVTITTARSKYPYHFFITSTGDVVDISPFYNGTNRNASYFGENADKFFIFPNYTIVSDFGRPNSALETHRLVAFLERADSVISWDIQDEKNVTCQLTFWEASERTIRSEAEDSYHFSSAKMTATFLSKKQEVNMSDSALDCVRDEAINKLQQIFNTSYNQTYEKYGNVSVFETTGGLVVFWQGIKQKSLVELERLANRSSLNLTHNSTKSSTDGNNATHLSNMESVHNLVYAQLQFTYDTLRGYINRALAQIAEAWCVDQRRTLEVFKELSKINPSAILSAIYNKPIAARFMGDVLGLASCVTINQTSVKVLRDMNVKESPGRCYSRPVVIFNFANSSYVQYGQLGEDNEILLGNHRTEECQLPSLKIFIAGNSAYEYVDYLFKRMIDLSSISTVDSMIALDCDPLCNTDFRVLELYSQKELRSSNVFDLEEIMREFNSYKQRVKYVEDKVVDPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGAAASLEVLFQGPGHHHHHHHHSAWSHPQFEKGGASGGGGSGGSAWSHPQFEK

CDR Sequences (chothia definition)
CDRH1	GYTFTDY
CDRH2	NPNSGG
CDRH3	DSAKTASAYYGLNFFYYGMDV
CDRL1	SGSSSNIGKNYVY
CDRL2	KNNQRPS
CDRL3	SAWDGSLSRPL

Orientation Angles (from ABangle)
HL	-56.83°
HC1	72.86°
HC2	112.78°
LC1	123.22°
LC2	83.64°
dc	16.09Å

Fv Details
Heavy chain	N
Light chain	O
Heavy subgroup	IGHV4
Light subgroup	IGLV1
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	True

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	31A	31B	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	100B	101	102	103	104	105	106	107	108	109	110	111	112	113
Q	L	Q	L	Q	E	S	G	P	G	L	V	K	P	S	E	T	L	S	L	T	C	T	V	S	G	A	S	I	D	R	S	T	Y	Y	W	G	W	I	R	Q	P	P	G	K	G	L	E	W	I	A	N	I	Y	Y	N	G	R	A	V	Y	S	P	S	L	K	S	R	V	T	I	S	V	D	T	S	K	N	Q	F	S	L	K	V	R	S	L	T	A	A	D	T	A	V	Y	Y	C	A	T	R	W	N	Y	F	F	D	F	D	Y	W	G	R	G	T	L	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	30A	30B	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
Q	S	V	L	T	Q	P	P	S	A	S	G	T	P	G	Q	R	V	T	I	S	C	S	G	S	S	S	N	I	E	T	N	Y	V	S	W	Y	Q	Q	F	P	G	T	A	P	K	L	L	I	Y	R	N	N	Q	R	P	S	G	V	P	D	R	F	S	G	S	K	S	G	T	S	A	S	L	A	I	S	G	L	R	S	E	D	E	A	E	Y	Y	C	G	T	W	D	D	N	S	W	V	F	G	G	G	T	K	L	T	V	L

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	envelope glycoprotein b
Antigen species	HUMAN BETAHERPESVIRUS 5
Antigen sequence	MESRIWCLVVCVNLCIVCLGAAVSSSSTRGTSATHSHHSSHTTSAAHSRSGSVSQRVTSSQTVSHGVNETIYNTTLKYGDVVGVNTTKYPYRVCSMAQGLDLIRFERNIVCTSMKPINEDLDEGIMVVYKRNICAHTFKVRVYQKVLTFRRSYAYIHTTYLLGSNTEYVAPPMWEIHHINSHSQCYSSYSRVIAGTVFVAYHRDSYENKTMQLMPDDYSNTCSTRYVTVKDQWHSRGSTWLYRETSNLNCMVTITTARSKYPYHFFITSTGDVVDISPFYNGTNRNASYFGENADKFFIFPNYTIVSDFGRPNSALETHRLVAFLERADSVISWDIQDEKNVTCQLTFWEASERTIRSEAEDSYHFSSAKMTATFLSKKQEVNMSDSALDCVRDEAINKLQQIFNTSYNQTYEKYGNVSVFETTGGLVVFWQGIKQKSLVELERLANRSSLNLTHNSTKSSTDGNNATHLSNMESVHNLVYAQLQFTYDTLRGYINRALAQIAEAWCVDQRRTLEVFKELSKINPSAILSAIYNKPIAARFMGDVLGLASCVTINQTSVKVLRDMNVKESPGRCYSRPVVIFNFANSSYVQYGQLGEDNEILLGNHRTEECQLPSLKIFIAGNSAYEYVDYLFKRMIDLSSISTVDSMIALDCDPLCNTDFRVLELYSQKELRSSNVFDLEEIMREFNSYKQRVKYVEDKVVDPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGAAASLEVLFQGPGHHHHHHHHSAWSHPQFEKGGASGGGGSGGSAWSHPQFEK

CDR Sequences (chothia definition)
CDRH1	GASIDRSTY
CDRH2	YYNGR
CDRH3	RWNYFFDFDY
CDRL1	SGSSSNIETNYVS
CDRL2	RNNQRPS
CDRL3	GTWDDNSWV

Orientation Angles (from ABangle)
HL	-55.03°
HC1	73.35°
HC2	121.55°
LC1	121.5°
LC2	79.76°
dc	16.18Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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