Structure Viewer: 8z8m

> Structure details

Crystal Structure of Human Tnf alpha in complex with Tnf30(Vhh) Domain of Ozoralizumab

PDB	8z8m
Species	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.59Å
Number of Fvs	6
In complex	True
Light chain type	NA
Has constant region	False

> Fv information

This PDB has 6 Fv(s).

Fv Details
Heavy chain	B
Light chain
Heavy subgroup	IGHV3
Light subgroup	NA
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	S	D	Y	W	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	S	E	I	N	T	N	G	L	I	T	K	Y	P	D	S	V	K	G	R	F	T	I	S	R	D	N	A	K	N	T	L	Y	L	Q	M	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	S	P	S	G	F	N	R	G	Q	G	T	L	V	T	V	S	S

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	tumor necrosis factor
Antigen species	HOMO SAPIENS
Antigen sequence	VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

CDR Sequences (chothia definition)
CDRH1	GFTFSDY
CDRH2	NTNGLI
CDRH3	SPSGFN

Fv Details
Heavy chain	D
Light chain
Heavy subgroup	IGHV3
Light subgroup	NA
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	S	D	Y	W	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	S	E	I	N	T	N	G	L	I	T	K	Y	P	D	S	V	K	G	R	F	T	I	S	R	D	N	A	K	N	T	L	Y	L	Q	M	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	S	P	S	G	F	N	R	G	Q	G	T	L	V	T	V	S	S

Antigen Details
Antigen chains	C
Antigen type	protein
Antigen name	tumor necrosis factor
Antigen species	HOMO SAPIENS
Antigen sequence	VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

CDR Sequences (chothia definition)
CDRH1	GFTFSDY
CDRH2	NTNGLI
CDRH3	SPSGFN

Fv Details
Heavy chain	F
Light chain
Heavy subgroup	IGHV3
Light subgroup	NA
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	S	D	Y	W	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	S	E	I	N	T	N	G	L	I	T	K	Y	P	D	S	V	K	G	R	F	T	I	S	R	D	N	A	K	N	T	L	Y	L	Q	M	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	S	P	S	G	F	N	R	G	Q	G	T	L	V	T	V	S	S

Antigen Details
Antigen chains	E
Antigen type	protein
Antigen name	tumor necrosis factor
Antigen species	HOMO SAPIENS
Antigen sequence	VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

CDR Sequences (chothia definition)
CDRH1	GFTFSDY
CDRH2	NTNGLI
CDRH3	SPSGFN

Fv Details
Heavy chain	H
Light chain
Heavy subgroup	IGHV3
Light subgroup	NA
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	S	D	Y	W	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	S	E	I	N	T	N	G	L	I	T	K	Y	P	D	S	V	K	G	R	F	T	I	S	R	D	N	A	K	N	T	L	Y	L	Q	M	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	S	P	S	G	F	N	R	G	Q	G	T	L	V	T	V	S	S

Antigen Details
Antigen chains	G
Antigen type	protein
Antigen name	tumor necrosis factor
Antigen species	HOMO SAPIENS
Antigen sequence	VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

CDR Sequences (chothia definition)
CDRH1	GFTFSDY
CDRH2	NTNGLI
CDRH3	SPSGFN

Fv Details
Heavy chain	J
Light chain
Heavy subgroup	IGHV3
Light subgroup	NA
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	S	D	Y	W	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	S	E	I	N	T	N	G	L	I	T	K	Y	P	D	S	V	K	G	R	F	T	I	S	R	D	N	A	K	N	T	L	Y	L	Q	M	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	S	P	S	G	F	N	R	G	Q	G	T	L	V	T	V	S	S

Antigen Details
Antigen chains	I
Antigen type	protein
Antigen name	tumor necrosis factor
Antigen species	HOMO SAPIENS
Antigen sequence	VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

CDR Sequences (chothia definition)
CDRH1	GFTFSDY
CDRH2	NTNGLI
CDRH3	SPSGFN

Fv Details
Heavy chain	L
Light chain
Heavy subgroup	IGHV3
Light subgroup	NA
Species	HOMO SAPIENS
In complex?	True
scFv?	False
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	52A	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	101	102	103	104	105	106	107	108	109	110	111	112	113
E	V	Q	L	V	E	S	G	G	G	L	V	Q	P	G	G	S	L	R	L	S	C	A	A	S	G	F	T	F	S	D	Y	W	M	Y	W	V	R	Q	A	P	G	K	G	L	E	W	V	S	E	I	N	T	N	G	L	I	T	K	Y	P	D	S	V	K	G	R	F	T	I	S	R	D	N	A	K	N	T	L	Y	L	Q	M	N	S	L	R	P	E	D	T	A	V	Y	Y	C	A	R	S	P	S	G	F	N	R	G	Q	G	T	L	V	T	V	S	S

Antigen Details
Antigen chains	K
Antigen type	protein
Antigen name	tumor necrosis factor
Antigen species	HOMO SAPIENS
Antigen sequence	VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

CDR Sequences (chothia definition)
CDRH1	GFTFSDY
CDRH2	NTNGLI
CDRH3	SPSGFN

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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