Structure Viewer: 9gw5

>   Structure details

Type-I interferon autoantibodies Pmab3, Pmab19 and Pmab14 in complex with interferon alpha-2

PDB9gw5
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution4Å
Number of Fvs3
In complexTrue
Light chain typeunknown
Has constant regionFalse
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>   Fv information

This PDB has 3 Fv(s).

>   H/H
Fv Details
Heavy chainH
Light chainH
Heavy subgroupunknown
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?True
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V Q P G G S L R L S C A A S G F T F S S H A M S W V R Q P P G K G L E W V S S I S A A G G S T Y Y A A S V K G R F T I S R D N S N K T L Y L Q M N S L R A E D T A I Y Y C A K E S D R V T T L D W F D P W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C R A S Q S I S S Y L N W Y Q Q K P G Q A P K L L I Y A A S S L Q T G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C Q Q S Y I T P L T F G G G T K V E I K

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen nameinterferon alpha-2
Antigen speciesHOMO SAPIENS
Antigen sequenceCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKEGGGGSLVPRGSGGGSHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GFTFSSH
CDRH2SAAGGS
CDRH3ESDRVTTLDWFDP
CDRL1RASQSISSYLN
CDRL2AASSLQT
CDRL3QQSYITPLT

Orientation Angles (from ABangle)
HL-59.98°
HC171.5°
HC2118.99°
LC1119.46°
LC282.01°
dc15.98Å
>   U/U
Fv Details
Heavy chainU
Light chainU
Heavy subgroupunknown
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?True
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V Q S G A E V K K P G A S V K V S C K T S G Y T F T S Y D I N W V R Q A T G Q G L E W M G W M N P N T G N T G Y A Q K F Q G R V A M T R S S S T R T A Y M E L S S L T S E D T A V Y Y C A R A G L T G A G L D D Y W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106
D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I R K Y L N W Y Q Q K P G K A P K L L I Y D A S N L Q T G V P S R F S G S G S G T D F T L T I S R L Q P E D I A T Y Y C Q Q Y G D L P L T F G G G T K V G I

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen nameinterferon alpha-2
Antigen speciesHOMO SAPIENS
Antigen sequenceCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKEGGGGSLVPRGSGGGSHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYTFTSY
CDRH2NPNTGN
CDRH3AGLTGAGLDDY
CDRL1QASQDIRKYLN
CDRL2DASNLQT
CDRL3QQYGDLPLT

Orientation Angles (from ABangle)
HL-58.91°
HC173.26°
HC2117.74°
LC1123.15°
LC280.65°
dc15.97Å
>   V/V
Fv Details
Heavy chainV
Light chainV
Heavy subgroupunknown
Light subgroupunknown
SpeciesHOMO SAPIENS
In complex?True
scFv?True
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L V Q S G A E V K K P G A S V K V S C K A S G Y D F S R F S I H W V R Q A P G Q R L E W M G W L I T G N G D A K Y S Q K F Q G R V T I S R N I S A S T A Y M E V T N L R S E D S A V Y Y C S R D P V A A G L W G Q G T L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
E I L L T Q S P G T L S L S P G E R A T L S C R A S Q F V S S T Y L A W Y Q H K P G Q A P R L L I Y G A S S R A T G I P D R F S G S G S G T D F T L T I N G L E P E D F A V Y Y C Q Q Y G S S P R T F G Q G T K V E I K

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen nameinterferon alpha-2
Antigen speciesHOMO SAPIENS
Antigen sequenceCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKEGGGGSLVPRGSGGGSHHHHHHHH

CDR Sequences (chothia definition)
CDRH1GYDFSRF
CDRH2ITGNGD
CDRH3DPVAAGL
CDRL1RASQFVSSTYLA
CDRL2GASSRAT
CDRL3QQYGSSPRT

Orientation Angles (from ABangle)
HL-59.47°
HC175.35°
HC2112.66°
LC1119.16°
LC279.72°
dc15.72Å
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Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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