Structure Viewer: 9kve

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Cryo-Em Structure of Sars-Cov-2 Prototype Spike Protein in complex with Triple-Nab 4H1, 4a5 and 4C1

PDB9kve
SpeciesMACACA MULATTA
MethodELECTRON MICROSCOPY
Resolution2.98Å
Number of Fvs3
In complexTrue
Light chain typeKappa,Lambda
Has constant regionFalse
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>   Fv information

This PDB has 3 Fv(s).

>   A/B
Fv Details
Heavy chainA
Light chainB
Heavy subgroupIGHV3
Light subgroupIGLV1
SpeciesMACACA MULATTA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L A K P G G S L R L S C A A S G F T F S S Y W M N W V R Q A P G K G L E W V S V I N S G G D N A Y Y A D S V K G R F T T S R D N S K S T L S L Q M N S L R E E D T A V Y Y C A K D R N L Y Y Y D S G Y Y T E F S F D Y W G Q G V L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 96 97 98 99 100 101 102 103 104 105 106 107
Q S V L T Q P P S V S G D P G Q S V T I S C T G S S S N I G G Y Y V N W Y Q Q F P G T A P K L L I Y D D N N R P S G V S D R F S G S K S G T S A S L T I T G L Q P G D E A D Y H C S G W D S S L S A V L F G R G T R L T V L

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namespike protein s1
Antigen speciesSEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequenceNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP

CDR Sequences (chothia definition)
CDRH1GFTFSSY
CDRH2NSGGDN
CDRH3DRNLYYYDSGYYTEFSFDY
CDRL1TGSSSNIGGYYVN
CDRL2DDNNRPS
CDRL3SGWDSSLSAVL

Orientation Angles (from ABangle)
HL-60.8°
HC172.99°
HC2117.39°
LC1118.39°
LC282.47°
dc15.91Å
>   E/G
Fv Details
Heavy chainE
Light chainG
Heavy subgroupIGHV3
Light subgroupIGKV1
SpeciesMACACA MULATTA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 101 102 103 104 105 106 107 108 109 110 111 112 113
E V Q L V E S G G G L V K P G G S L R L S C V A S G F T F S D Y E M H W V R Q A P G K G L E W V S V I S E S G G T T Y Y A D S V K G R F T I S R D N A K N S L F L Q M N S L R A E D T A V Y Y C T R V V I V V F T A M R H F D Y W G Q G V L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A P V G D T V T I T C R A S Q G I N S Y L N W F Q Q K P G K A P K L L I Y D A S T L E S G V P S R F S G S G S G T D F T L T I S S L Q P E D F A T Y Y C L Q Y N N Y P F T F G P G T R L D I K

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namespike protein s1
Antigen speciesSEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequenceNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP

CDR Sequences (chothia definition)
CDRH1GFTFSDY
CDRH2SESGGT
CDRH3VVIVVFTAMRHFDY
CDRL1RASQGINSYLN
CDRL2DASTLES
CDRL3LQYNNYPFT

Orientation Angles (from ABangle)
HL-58.83°
HC170.91°
HC2119.58°
LC1121.71°
LC283.2°
dc16.45Å
>   D/F
Fv Details
Heavy chainD
Light chainF
Heavy subgroupIGHV4
Light subgroupIGKV2
SpeciesMACACA MULATTA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 101 102 103 104 105 106 107 108 109 110 111 112 113
Q V Q L Q E S G P G L V K P S E T L S L S C A V S G A S I S S Y W W N W F R Q S P G K G L E W I G K I N G N S G I T Y Y N P S L K S R L T I S K D A S K K Q L S L T L T S V T A A D T A V Y F C A T R D G N I V G V A D Y W G Q G V L V T V S S

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 30D 30E 30F 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D V V M T Q T P L S L P V T P G E P A S I S C R S S Q S L F D G G H P Y T S L D W Y L Q K P G Q S P Q L L I Y M V S N R A S G V P D R F S G S A S G T D F T L K I S R V E A E D V G V Y F C M Q S V E Y P Y S F G Q G T T V D F K

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namespike protein s1
Antigen speciesSEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS2
Antigen sequenceNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP

CDR Sequences (chothia definition)
CDRH1GASISSY
CDRH2NGNSGI
CDRH3RDGNIVGVADY
CDRL1RSSQSLFDGGHPYTSLD
CDRL2MVSNRAS
CDRL3MQSVEYPYS

Orientation Angles (from ABangle)
HL-58.61°
HC174.47°
HC2120.43°
LC1118.19°
LC285.08°
dc16.99Å
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Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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