Thera-SAbDab

DACETUZUMAB

> Structural Summary

Therapeutic	Dacetuzumab
Target	TNFRSF5/CD40
Heavy Chain	EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYYIHWVRQAPGKGLEWVARVIPNAGGTSYNQKFKGRFTLSVDNSKNTAYLQMNSLRAEDTAVYYCAREGIYWWGQGTLVTVSS
Light Chain	DIQMTQSPSSLSASVGDRVTITCRSSQSLVHSNGNTFLHWYQQKPGKAPKLLIYTVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCSQTTHVPWTFGQGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder2.

> SAbPred Links

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (Aug '24)	Phase-II
Estimated Status (Aug '24)	Discontinued
Recorded Developmental Technology
INN Year Proposed	2007
INN Year Recommended	2008
Companies Involved	Seattle Genetics
Conditions Approved	na
Conditions Active	na
Conditions Discontinued	Chronic lymphocytic leukaemia, Diffuse large B cell lymphoma, Multiple myeloma, Non-Hodgkin's lymphoma
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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