| Therapeutic | Ibalizumab |
| Target | CD4 |
| Heavy Chain | QVQLQQSGPEVVKPGASVKMSCKASGYTFTSYVIHWVRQKPGQGLDWIGYINPYNDGTDYDEKFKGKATLTSDTSTSTAYMELSSLRSEDTAVYYCAREKDNYATGAWFAYWGQGTLVTVSS |
| Light Chain | DIVMTQSPDSLAVSLGERVTMNCKSSQSLLYSTNQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSVQAEDVAVYYCQQYYSYRTFGGGTKLEIK |
| 100% seqID Fv Structure | 3o2d [Fvs: HL], 7t0r [Fvs: CB, HL] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 3o2d [Fvs: HL] |
| 100% seqID Structure | 7t0r [Fvs: CB, HL] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G4 |
| Highest Clinical Trial (Aug '24) | Approved |
| Estimated Status (Aug '24) | NFD |
| Recorded Developmental Technology | |
| INN Year Proposed | 2007 |
| INN Year Recommended | 2008 |
| Companies Involved | Biogen Idec, TaiMed Biologics, Theratechnologies |
| Conditions Approved | HIV-1 infections |
| Conditions Active | na |
| Conditions Discontinued | na |
| Notes | Biosimilar available |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
