| Therapeutic | Masavibart |
| Target | SARS-CoV-2 Spike RBD |
| Heavy Chain | QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYAMYWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRTEDTAVYYCASGSDYGDYLLVYWGQGTLVTVSS |
| Light Chain | QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSKRPSGVSNRFSGSKSGNTASLTISGLQSEDEADYYCNSLTSISTWVFGGGTKLTVL |
| 100% seqID Fv Structure | 6xdg [Fvs: CA], 7zjl [Fvs: jg, ji, lk], 8j1q [Fvs: BA], 8j26 [Fvs: BA] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 6xdg [Fvs: CA] |
| 100% seqID Structure | 7zjl [Fvs: jg, ji, lk] |
| 100% seqID Structure | 8j26 [Fvs: BA] |
| 100% seqID Structure | 8j1q [Fvs: BA] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G1 |
| Highest Clinical Trial (Feb '25) | Approved |
| Estimated Status (Feb '25) | Active |
| Recorded Developmental Technology | |
| INN Year Proposed | 2020 |
| INN Year Recommended | 2021 |
| Companies Involved | Regeneron Pharmaceuticals |
| Conditions Approved | COVID-19 |
| Conditions Active | na |
| Conditions Discontinued | na |
| Notes | Imdevimab is former name for Masavibart |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
