| Therapeutic | Ruplizumab |
| Target | CD40LG/CD154 |
| Heavy Chain | QVQLVQSGAEVVKPGASVKLSCKASGYIFTSYYMYWVKQAPGQGLEWIGEINPSNGDTNFNEKFKSKATLTVDKSASTAYMELSSLRSEDTAVYYCTRSDGRNDMDSWGQGTLVTVSS |
| Light Chain | DIVLTQSPATLSVSPGERATISCRASQRVSSSTYSYMHWYQQKPGQPPKLLIKYASNLESGVPARFSGSGSGTDFTLTISSVEPEDFATYYCQHSWEIPPTFGGGTKLEIK |
| 100% seqID Fv Structure | 1i9r [Fvs: HL, KM, XY], 6w4w [Fvs: HL] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 1i9r [Fvs: HL, KM, XY] |
| 100% seqID Structure | 6w4w [Fvs: HL] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G1 |
| Highest Clinical Trial (Aug '24) | Phase-II |
| Estimated Status (Aug '24) | Discontinued |
| Recorded Developmental Technology | |
| INN Year Proposed | 2000 |
| INN Year Recommended | 2001 |
| Companies Involved | Biogen |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | Autoimmune disorders, Haemophilia A, Idiopathic thrombocytopenic purpura, Multiple sclerosis, Renal transplant rejection, Systemic lupus erythematosus |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
