| Therapeutic | Safimestomig |
| Target 1 | IAP/CD47 |
| Heavy Chain 1 | EVQLVQSGAEVKKPGASVKVSCKASGYKFTNYVMSWVRQAPGQRLEWMGYINPYNDAIKYNEKFTGRVTITRDTSASTAYMELSSLRSEDTAVYYCAREGDFYANYGRLGFAYWGQGTLVTVSS |
| Light Chain 1 | DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLLYYTSRLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYFCQQGAGFPYTFGGGTKVEIK |
| 100% seqID Fv 1 Structure | 7xjf [Fvs: HL] |
| 99% seqID Fv 1 Structure | None |
| 95-98% seqID Fv 1 Structure | None |
| Target 2 | PDL1/CD274 |
| Heavy Chain 2 | EVQLVQSGAEVKKPGATVKISCKVSGFNIKDIYMHWVQQAPGKGLEWMGRIDPANANTKYDPKFQDRVTITADTSTNTAYMELSSLRSEDTAVYYCASGQLGPLGFDYWGQGTTVTVSS |
| Light Chain 2 | DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLLYYTSRLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYFCQQGAGFPYTFGGGTKVEIK |
| 100% seqID Fv 2 Structure | None |
| 99% seqID Fv 2 Structure | None |
| 95-98% seqID Fv 2 Structure | None |
| 100% seqID Structure [Fv 1] | 7xjf [Fvs: HL] |
| There are no identical PDB matches to at least one Fv in this therapeutic. Click the links to build models with ABodyBuilder2: [Fv 1] [Fv 2] |
Follow these links to our prediction tools:
| Format | Bispecific Whole mAb |
| Isotype | G4 |
| Highest Clinical Trial (Aug '24) | Phase-II |
| Estimated Status | Active |
| Recorded Developmental Technology | |
| INN Year Proposed | 2024 |
| INN Year Recommended | None |
| Companies Involved | Mabwell (Shanghai) Bioscience |
| Conditions Approved | na |
| Conditions Active | Solid tumours |
| Conditions Discontinued | na |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
