| Therapeutic | Simaravibart |
| Target | SARS-CoV-2 Spike RBD |
| Heavy Chain | QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYTISWVRQAPGQGLEWMGRIIPILDRVMYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARRAIDSDTYVEQSHFDYWGQGTLVTVSS |
| Light Chain | EIVMTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPSLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQPLTFGGGTKVEIK |
| 100% seqID Fv Structure | 7s6j [Fvs: CD, FG, HL], 7s6k [Fvs: CD, FG, HL], 7s6l [Fvs: HL], 7sbu [Fvs: HL] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 7s6j [Fvs: CD, FG, HL] |
| 100% seqID Structure | 7s6k [Fvs: CD, FG, HL] |
| 100% seqID Structure | 7s6l [Fvs: HL] |
| 100% seqID Structure | 7sbu [Fvs: HL] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G1 |
| Highest Clinical Trial (Aug '24) | Phase-II/III |
| Estimated Status (Aug '24) | Active |
| Recorded Developmental Technology | |
| INN Year Proposed | 2022 |
| INN Year Recommended | None |
| Companies Involved | Toscana Life Sciences |
| Conditions Approved | na |
| Conditions Active | COVID-19 |
| Conditions Discontinued | na |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
