| Therapeutic | Vobarilizumab |
| Target 1 | IL6R/CD126 |
| Heavy Chain 1 | EVQLVESGGGLVQPGGSLRLSCAASGSVFKINVMAWYRQAPGKGRELVAGIISGGSTSYADSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYYCAFITTESDYDLGRRYWGQGTLVTVSS |
| Light Chain 1 | na |
| 100% seqID Fv 1 Structure | 7xl0 [Fvs: A, B] |
| 99% seqID Fv 1 Structure | None |
| 95-98% seqID Fv 1 Structure | None |
| Target 2 | ALB |
| Heavy Chain 2 | EVQLVESGGGLVQPGNSLRLSCAASGFTFSSFGMSWVRQAPGKGLEWVSSISGSGSDTLYADSVKGRFTISRDNAKTTLYLQMNSLRPEDTAVYYCTIGGSLSRSSQGTLVTVSS |
| Light Chain 2 | na |
| 100% seqID Fv 2 Structure | None |
| 99% seqID Fv 2 Structure | None |
| 95-98% seqID Fv 2 Structure | None |
| 100% seqID Structure [Fv 1] | 7xl0 [Fvs: A, B] |
| There are no identical PDB matches to at least one Fv in this therapeutic. Click the links to build models with ABodyBuilder2: [Fv 1] [Fv 2] |
Follow these links to our prediction tools:
| Format | Bispecific Single Domains (VH-VH') |
| Isotype | na;na |
| Highest Clinical Trial (Feb '25) | Phase-II |
| Estimated Status (Feb '25) | Discontinued |
| Recorded Developmental Technology | Nanobody Technology |
| INN Year Proposed | 2015 |
| INN Year Recommended | 2016 |
| Companies Involved | Ablynx |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | Rheumatoid arthritis, Systemic lupus erythematosus |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
