Thera-SAbDab

CALPURBATUG

> Structural Summary

Therapeutic	Calpurbatug
Target	Bacteria Proteins HU and IHF
Heavy Chain	QSQVQLVESGPGLVKPSETLSLTCRVSGDSNRPSYWSWIRQAPGKAMEWIGYVYDSGVTIYNPSLKGRVTISLDTSKTRFSLKLTSVIAADTAVYYCARERFDRTSYKSWWGQGTQVTVSS
Light Chain	DIVLTQAPGTLSLSPGDRATLSCRASQRLGGTSLAWYQHRSGQAPRLILYGTSNRATDTPDRFSGSGSGTDFVLTISSLEPEDFAVYYCQQYGSPPYTFGQGTTLDIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (August '23)	TBC
Estimated Status (August '23)	Active
Recorded Developmental Technology	TBC
INN Year Proposed	2022
INN Year Recommended	None
Companies Involved	TBc
Conditions Approved	TBC
Conditions Active	TBC
Conditions Discontinued	TBC
Notes	Conserved epitopes on HU (histone-like protein) and IHF (integrin host factor)

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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