Thera-SAbDab

GANITUMAB

> Structural Summary

Therapeutic	Ganitumab
Target	IGF1R/CD221
Heavy Chain	QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGSTNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCARWTGRTDAFDIWGQGTMVTVSS
Light Chain	DVVMTQSPLSLPVTPGEPASISCRSSQSLLHSNGYNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGTHWPLTFGQGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder2.

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (Feb '25)	Phase-III
Estimated Status (Feb '25)	Discontinued
Recorded Developmental Technology
INN Year Proposed	2010
INN Year Recommended	2011
Companies Involved	Amgen, Millennium, NantWorks, National Cancer Institute (USA), Novartis, Takeda, Takeda Oncology, UCLAs Jonsson Comprehensive Cancer Center
Conditions Approved	na
Conditions Active	na
Conditions Discontinued	Breast cancer, Colorectal cancer, Sarcoma, Small cell lung cancer, Non-small cell lung cancer, Pancreatic cancer, Prostate cancer, Ewing's sarcoma, Solid tumours, Rhabdomyosarcoma
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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